| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Last Airbender | $688,250 | - | 75 | - | $9,176 | $688,250 | 1 | Paramount Pictures International | true | false |
| 2 | 2 | Grown Ups | $113,167 | -32.1% | 40 | - | $2,829 | $343,018 | 2 | Sony Pictures Releasing | false | false |
| 3 | 1 | Cats & Dogs: The Revenge of Kitty Galore | $108,644 | -59.4% | 66 | - | $1,646 | $1,034,928 | 3 | Warner Bros. | false | false |
| 4 | 3 | Predators | $76,563 | -52.7% | 37 | - | $2,069 | $304,541 | 2 | 20th Century Fox International | false | false |
| 5 | - | From Paris with Love | $51,657 | - | 22 | - | $2,348 | $51,657 | 1 | N/A | true | false |
| 6 | - | Undertow | $49,905 | - | 22 | - | $2,268 | $49,905 | 1 | N/A | true | false |
| 7 | - | Lila, Lila | $31,429 | - | 15 | - | $2,095 | $31,429 | 1 | N/A | true | false |
| 8 | 4 | The Karate Kid | $31,047 | -70% | 31 | -12 | $1,001 | $979,852 | 4 | Sony Pictures Releasing | false | false |
| 9 | 6 | Letters to Juliet | $25,421 | -57% | 25 | - | $1,016 | $111,026 | 2 | Venus | false | false |
| 10 | 8 | Inception | $22,472 | -53.3% | 52 | - | $432 | $970,792 | 5 | Warner Bros. | false | false |
| 11 | 7 | The Haunting of Molly Hartley | $22,087 | -61.4% | 20 | - | $1,104 | $104,932 | 2 | N/A | false | false |
| 12 | 9 | The Rebound | $17,268 | -49.1% | 15 | - | $1,151 | $155,854 | 3 | N/A | false | false |
| 13 | 5 | Despicable Me | $7,782 | -88.2% | 47 | -15 | $165 | $2,061,766 | 5 | Universal Pictures International (UPI) | false | false |
| 14 | 18 | The Last Song | $5,464 | +640.4% | 13 | - | $420 | $106,521 | 13 | Walt Disney Pictures | false | false |
| 15 | 10 | Pope Joan | $4,685 | -81.9% | 14 | - | $334 | $42,257 | 2 | N/A | false | false |
| 16 | - | The Fourth Kind | $3,930 | - | 16 | - | $245 | $316,369 | 15 | N/A | false | false |
| 17 | 11 | The Sorcerer's Apprentice | $3,533 | -79.5% | 43 | - | $82 | $1,278,676 | 6 | Walt Disney Pictures | false | false |
| 18 | - | Daybreakers | $1,920 | - | 21 | - | $91 | $155,229 | 10 | N/A | false | false |
| 19 | 20 | The Book of Eli | $1,433 | +175.6% | 2 | +1 | $716 | $271,779 | 21 | Sony Pictures Releasing | false | false |
| 20 | 12 | Dorothy Mills | $747 | -94.8% | 25 | - | $29 | $302,263 | 4 | N/A | false | false |
| 21 | - | The Bounty Hunter | $480 | - | 1 | - | $480 | $267,888 | 17 | Sony Pictures Releasing | false | false |
| 22 | 14 | Shrek Forever After | $230 | -94% | 53 | - | $4 | $4,081,129 | 8 | Paramount Pictures International | false | false |
| 23 | 16 | The Twilight Saga: Eclipse | $27 | -98.3% | 67 | - | $0 | $2,325,279 | 7 | N/A | false | false |
