| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Grown Ups | $297,623 | - | 65 | - | $4,578 | $297,623 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Shrek Forever After | $293,450 | -35% | 94 | -10 | $3,121 | $2,704,890 | 4 | United International Pictures | false | false |
| 3 | 2 | Inception | $219,022 | -5.7% | 61 | - | $3,590 | $583,894 | 2 | Warner Bros. | false | false |
| 4 | - | Cats & Dogs: The Revenge of Kitty Galore | $179,912 | - | 71 | - | $2,533 | $179,912 | 1 | Warner Bros. | true | false |
| 5 | 3 | Knight and Day 2010 Re-release | $158,990 | -25.4% | 71 | +1 | $2,239 | $958,578 | 3 | 20th Century Fox International | false | false |
| 6 | 4 | The Twilight Saga: Eclipse | $68,709 | -37.9% | 76 | -9 | $904 | $3,744,343 | 6 | NuMetro Distribution | false | false |
| 7 | - | Predators | $66,514 | - | 40 | - | $1,662 | $66,514 | 1 | 20th Century Fox International | true | false |
| 8 | - | Mao's Last Dancer | $45,619 | - | 15 | - | $3,041 | $45,619 | 1 | NuMetro Distribution | true | false |
| 9 | 7 | Death at a Funeral | $29,657 | -28.6% | 26 | -9 | $1,140 | $1,018,782 | 8 | Sony Pictures Releasing | false | false |
| 10 | 5 | Toy Story 3 | $28,001 | -61.1% | 36 | -24 | $777 | $3,271,402 | 7 | Walt Disney Pictures | false | false |
| 11 | 8 | Our Family Wedding | $25,450 | -34.5% | 20 | - | $1,272 | $80,842 | 2 | NuMetro Distribution | false | false |
| 12 | 6 | Schuks Tshabalala's Survival Guide to South Africa | $18,762 | -69.7% | 29 | -45 | $646 | $5,184,039 | 11 | N/A | false | false |
| 13 | 10 | She's Out of My League | $15,466 | -17.7% | 23 | -4 | $672 | $641,737 | 7 | United International Pictures | false | false |
| 14 | 14 | The White Ribbon | $11,770 | +59.8% | 7 | - | $1,681 | $23,790 | 2 | United International Pictures | false | false |
| 15 | 13 | The Boys Are Back | $8,127 | -4% | 8 | -2 | $1,015 | $91,857 | 5 | N/A | false | false |
| 16 | 18 | Broken Embraces | $4,257 | +6.2% | 5 | - | $851 | $79,291 | 8 | Ster-Kinekor Pictures | false | false |
| 17 | 17 | Creation | $3,233 | -20.1% | 7 | - | $461 | $72,239 | 7 | Ster-Kinekor Pictures | false | false |
| 18 | 22 | Antichrist | $1,825 | -10% | 2 | - | $912 | $5,182 | 2 | United International Pictures | false | false |
| 19 | - | A Serious Man | $1,444 | - | 2 | - | $722 | $105,268 | 13 | Ster-Kinekor Pictures | false | false |
| 20 | 19 | I Love You Phillip Morris | $1,187 | -69.8% | 4 | -3 | $296 | $154,362 | 5 | United International Pictures | false | false |
| 21 | 23 | Themba | $1,118 | -35.9% | 4 | -2 | $279 | $17,457 | 4 | N/A | false | false |
| 22 | 25 | Green Zone 2010 Re-release | $942 | +52.9% | 1 | -2 | $942 | $292,023 | 11 | United International Pictures | false | false |
| 23 | - | For Better for Worse | $829 | - | 1 | - | $829 | $36,520 | 6 | N/A | false | false |
