| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 15 | 15 | Get Him to the Greek | $803 | +158.2% | 2 | - | $401 | $159,807 | 9 | Universal Pictures International (UPI) | false | false |
| 20 | 17 | Cop Out | $144 | +23.1% | 1 | -1 | $144 | $158,881 | 9 | Warner Bros. | false | false |
| 18 | 16 | Prince of Persia: The Sands of Time | $260 | -13% | 1 | - | $260 | $1,581,120 | 11 | Walt Disney Pictures | false | false |
| 13 | 10 | Shrek Forever After | $2,153 | -21% | 2 | - | $1,076 | $4,017,670 | 13 | Paramount Pictures International | false | false |
| 14 | 12 | Knight and Day 2010 Re-release | $1,145 | -21.1% | 5 | +1 | $229 | $603,893 | 8 | 20th Century Fox International | false | false |
| 4 | 3 | Inception | $91,576 | -33.8% | 51 | -1 | $1,795 | $1,107,616 | 4 | Warner Bros. | false | false |
| 11 | 9 | Predators | $5,211 | -36.6% | 18 | -14 | $289 | $389,566 | 6 | 20th Century Fox International | false | false |
| 8 | 6 | Despicable Me | $27,212 | -48.2% | 47 | -25 | $578 | $1,038,274 | 5 | Universal Pictures International (UPI) | false | false |
| 6 | 4 | Cats & Dogs: The Revenge of Kitty Galore | $50,628 | -48.6% | 54 | -1 | $937 | $408,407 | 3 | Warner Bros. | false | false |
| 7 | 5 | The Sorcerer's Apprentice | $43,287 | -49.4% | 80 | -6 | $541 | $1,149,374 | 4 | Walt Disney Pictures | false | false |
| 2 | 1 | Grown Ups | $124,141 | -50.2% | 50 | - | $2,482 | $474,553 | 2 | Sony Pictures Releasing | false | false |
| 16 | 11 | Avatar | $790 | -51.9% | 2 | -1 | $395 | $8,296,391 | 35 | 20th Century Fox International | false | false |
| 5 | 2 | Salt | $67,535 | -68% | 75 | -3 | $900 | $1,098,713 | 3 | Sony Pictures Releasing | false | false |
| 10 | 7 | The Last Airbender | $8,791 | -70.6% | 35 | -35 | $251 | $1,714,563 | 6 | Paramount Pictures International | false | false |
| 12 | 8 | The Twilight Saga: Eclipse | $3,529 | -71.3% | 17 | -36 | $207 | $1,674,709 | 6 | N/A | false | false |
| 17 | 13 | Toy Story 3 | $293 | -72.4% | 5 | - | $58 | $665,520 | 8 | Walt Disney Pictures | false | false |
| 21 | 14 | The Alien Girl | $131 | -75% | 1 | -2 | $131 | $117,102 | 7 | N/A | false | false |
| 1 | - | The Expendables | $410,148 | - | 65 | - | $6,309 | $410,148 | 1 | N/A | true | false |
| 3 | - | Step Up 3D | $108,787 | - | 32 | - | $3,399 | $108,787 | 1 | N/A | true | false |
| 9 | - | Tinker Bell and the Great Fairy Rescue | $21,719 | - | 36 | - | $603 | $21,719 | 1 | Walt Disney Pictures | true | false |
| 19 | - | The A-Team | $237 | - | 1 | - | $237 | $229,298 | 10 | 20th Century Fox International | false | false |
