| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Shrek Forever After | $451,643 | -31.8% | 104 | -1 | $4,342 | $2,308,576 | 3 | United International Pictures | false | false |
| 2 | - | Inception | $232,274 | - | 61 | - | $3,807 | $232,274 | 1 | Warner Bros. | true | false |
| 3 | 2 | Knight and Day 2010 Re-release | $213,199 | -42.1% | 70 | - | $3,045 | $714,901 | 2 | 20th Century Fox International | false | false |
| 4 | 3 | The Twilight Saga: Eclipse | $110,604 | -34.4% | 85 | -2 | $1,301 | $3,602,355 | 5 | NuMetro Distribution | false | false |
| 5 | 5 | Toy Story 3 | $72,027 | -26.4% | 60 | -7 | $1,200 | $3,193,859 | 6 | Walt Disney Pictures | false | false |
| 6 | 4 | Schuks Tshabalala's Survival Guide to South Africa | $61,893 | -39.8% | 74 | -13 | $836 | $5,096,446 | 10 | N/A | false | false |
| 7 | 6 | Death at a Funeral | $41,560 | -22% | 35 | +1 | $1,187 | $963,437 | 7 | Sony Pictures Releasing | false | false |
| 8 | - | Our Family Wedding | $38,839 | - | 20 | - | $1,941 | $38,839 | 1 | NuMetro Distribution | true | false |
| 9 | 7 | A Nightmare on Elm Street | $32,206 | -27% | 25 | - | $1,288 | $168,831 | 3 | NuMetro Distribution | false | false |
| 10 | 8 | She's Out of My League | $18,791 | -36.9% | 27 | -7 | $695 | $612,059 | 6 | United International Pictures | false | false |
| 11 | - | Letters to God | $17,419 | - | 20 | - | $870 | $17,419 | 1 | NuMetro Distribution | true | false |
| 12 | 9 | Killers | $16,933 | -29.6% | 28 | -1 | $604 | $1,085,954 | 9 | NuMetro Distribution | false | false |
| 13 | 10 | The Boys Are Back | $8,467 | -32.1% | 10 | - | $846 | $79,208 | 4 | N/A | false | false |
| 14 | - | The White Ribbon | $7,366 | - | 7 | - | $1,052 | $7,366 | 1 | United International Pictures | true | false |
| 15 | 13 | Letters to Juliet | $5,927 | -36.1% | 9 | -3 | $658 | $477,259 | 8 | NuMetro Distribution | false | false |
| 16 | 12 | Prince of Persia: The Sands of Time | $4,685 | -59.9% | 5 | -11 | $937 | $1,803,854 | 11 | Walt Disney Pictures | false | false |
| 17 | 16 | Creation | $4,047 | -24.6% | 7 | - | $578 | $66,164 | 6 | Ster-Kinekor Pictures | false | false |
| 18 | 17 | Broken Embraces | $4,008 | -19.6% | 5 | - | $801 | $72,625 | 7 | Ster-Kinekor Pictures | false | false |
| 19 | 11 | I Love You Phillip Morris | $3,936 | -68.1% | 7 | -16 | $562 | $149,302 | 4 | United International Pictures | false | false |
| 20 | 15 | Robin Hood | $3,070 | -46.3% | 4 | -5 | $767 | $1,140,199 | 12 | United International Pictures | false | false |
| 21 | 21 | The Back-up Plan | $2,085 | -32.6% | 4 | -2 | $521 | $770,599 | 13 | Sony Pictures Releasing | false | false |
| 22 | - | Antichrist | $2,027 | - | 2 | - | $1,013 | $2,027 | 1 | United International Pictures | true | false |
| 23 | 19 | Themba | $1,743 | -53.7% | 6 | -4 | $290 | $14,938 | 3 | N/A | false | false |
| 24 | 18 | Goal! III | $1,618 | -61.6% | 6 | -9 | $269 | $7,641 | 2 | United International Pictures | false | false |
| 25 | 25 | Green Zone 2010 Re-release | $616 | +4.2% | 3 | - | $205 | $287,828 | 10 | United International Pictures | false | false |
