| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Salt | $546,641 | - | 79 | - | $6,919 | $546,641 | 1 | Sony Pictures Releasing | true | false |
| 2 | 2 | Inception | $207,664 | -37.3% | 52 | - | $3,993 | $705,438 | 2 | Warner Bros. | false | false |
| 3 | 1 | The Sorcerer's Apprentice | $190,481 | -63.2% | 86 | -2 | $2,214 | $902,807 | 2 | Walt Disney Pictures | false | false |
| 4 | - | Cats & Dogs: The Revenge of Kitty Galore | $147,097 | - | 53 | - | $2,775 | $147,097 | 1 | Warner Bros. | true | false |
| 5 | 3 | Despicable Me | $75,520 | -62.8% | 72 | -1 | $1,048 | $902,278 | 3 | Universal Pictures International (UPI) | false | false |
| 6 | 5 | The Last Airbender | $37,858 | -61.8% | 71 | -7 | $533 | $1,641,201 | 4 | Paramount Pictures International | false | false |
| 7 | 6 | Predators | $11,586 | -51.7% | 35 | -12 | $331 | $360,783 | 4 | 20th Century Fox International | false | false |
| 8 | 7 | Toy Story 3 | $1,994 | -46.1% | 22 | -11 | $90 | $654,342 | 6 | Walt Disney Pictures | false | false |
| 9 | 8 | Knight and Day 2010 Re-release | $1,147 | -66.6% | 4 | -19 | $286 | $592,376 | 6 | 20th Century Fox International | false | false |
| 10 | 10 | Avatar | $353 | -77.5% | 2 | -1 | $176 | $8,292,633 | 33 | 20th Century Fox International | false | false |
| 11 | 11 | The Alien Girl | $290 | -51.7% | 4 | -7 | $72 | $115,935 | 5 | N/A | false | false |
| 12 | 17 | Get Him to the Greek | $202 | +329.8% | 2 | +1 | $101 | $158,400 | 7 | Universal Pictures International (UPI) | false | false |
| 13 | 16 | Shrek Forever After | $179 | +68.9% | 2 | +1 | $89 | $4,011,320 | 11 | Paramount Pictures International | false | false |
| 14 | 14 | The A-Team | $137 | -67.5% | 2 | -2 | $68 | $229,011 | 8 | 20th Century Fox International | false | false |
| 15 | 13 | Sex and the City 2 | $111 | -77.3% | 3 | -2 | $37 | $921,760 | 9 | Warner Bros. | false | false |
| 16 | 12 | Cop Out | $82 | -84% | 2 | -3 | $41 | $158,539 | 7 | Warner Bros. | false | false |
| 17 | 15 | Prince of Persia: The Sands of Time | $30 | -83.5% | 1 | -7 | $30 | $1,579,572 | 9 | Walt Disney Pictures | false | false |
