| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Inception | $1,135,879 | -14.6% | 103 | +2 | $11,027 | $3,181,917 | 2 | Warner Bros. | false | false |
| 2 | 3 | Shrek Forever After | $600,044 | -14.9% | 225 | -8 | $2,666 | $4,602,676 | 4 | Universal Pictures International (UPI) | false | false |
| 3 | 2 | The Karate Kid | $496,076 | -36.1% | 84 | - | $5,905 | $2,258,626 | 2 | Sony Pictures Releasing | false | false |
| 4 | - | The Sorcerer's Apprentice | $492,951 | - | 95 | - | $5,188 | $553,312 | 1 | Walt Disney Pictures | true | false |
| 5 | 5 | Toy Story 3 | $390,751 | -10.8% | 159 | -16 | $2,457 | $3,836,401 | 6 | Walt Disney Pictures | false | false |
| 6 | 4 | Knight and Day 2010 Re-release | $371,954 | -25.6% | 108 | +1 | $3,444 | $2,177,127 | 3 | Warner Bros. | false | false |
| 7 | - | Predators | $239,374 | - | 47 | - | $5,093 | $281,315 | 1 | Warner Bros. | true | false |
| 8 | - | Cats & Dogs: The Revenge of Kitty Galore | $219,557 | - | 93 | - | $2,360 | $318,027 | 1 | Warner Bros. | true | false |
| 9 | 6 | The Twilight Saga: Eclipse | $120,669 | -39.8% | 92 | -10 | $1,311 | $3,446,233 | 5 | Independent Films | false | false |
| 10 | - | Brooklyn's Finest 2010 Re-release | $59,997 | - | 19 | - | $3,157 | $86,063 | 1 | Benelux Film Distributors | true | false |
| 11 | 10 | Furry Vengeance | $31,498 | -15.1% | 64 | -2 | $492 | $202,401 | 3 | Entertainment One | false | false |
| 12 | 7 | Sex and the City 2 | $24,055 | -58.7% | 19 | -35 | $1,266 | $5,104,428 | 10 | Warner Bros. | false | false |
| 13 | 9 | Get Him to the Greek | $23,389 | -45.7% | 11 | -13 | $2,126 | $495,077 | 5 | Universal Pictures International (UPI) | false | false |
| 14 | 11 | Letters to Juliet | $23,073 | -27.3% | 20 | -12 | $1,153 | $685,994 | 7 | Entertainment One | false | false |
| 15 | - | My Afternoons with Margueritte | $19,111 | - | 8 | - | $2,388 | $22,479 | 1 | Cinéart | true | false |
| 16 | 8 | Unthinkable | $17,759 | -66% | 14 | -11 | $1,268 | $377,205 | 4 | A-Film Distribution | false | false |
| 17 | 17 | The Ghost Writer | $17,001 | +5.2% | 13 | -3 | $1,307 | $593,412 | 11 | Benelux Film Distributors | false | false |
| 18 | 12 | The Back-up Plan | $16,114 | -27.9% | 12 | -6 | $1,342 | $668,860 | 7 | Sony Pictures Releasing | false | false |
| 19 | 18 | Greenberg | $15,425 | +1.4% | 6 | - | $2,570 | $97,345 | 4 | Benelux Film Distributors | false | false |
| 20 | 20 | Me Too | $15,218 | +15.5% | 13 | - | $1,170 | $347,846 | 12 | A-Film Distribution | false | false |
| 21 | - | Five Minutes of Heaven | $10,776 | - | 7 | - | $1,539 | $10,776 | 1 | Benelux Film Distributors | true | false |
| 22 | - | Please Give | $4,109 | - | 2 | - | $2,054 | $4,109 | 1 | Sony Pictures Releasing | true | false |
