| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Toy Story 3 | $243,319 | - | 84 | - | $2,896 | $243,319 | 1 | Walt Disney Pictures | true | false |
| 2 | - | Knight and Day 2010 Re-release | $214,908 | - | 77 | - | $2,791 | $214,908 | 1 | 20th Century Fox International | true | false |
| 3 | 1 | Prince of Persia: The Sands of Time | $53,256 | -57.1% | 98 | -5 | $543 | $1,476,279 | 4 | Walt Disney Pictures | false | false |
| 4 | 2 | Shrek Forever After | $41,592 | -55.9% | 88 | -11 | $472 | $3,885,977 | 6 | Paramount Pictures International | false | false |
| 5 | - | Splice 2010 Re-release | $26,732 | - | 22 | - | $1,215 | $26,732 | 1 | N/A | true | false |
| 6 | 8 | Get Him to the Greek | $26,624 | -52.6% | 40 | -2 | $665 | $109,498 | 2 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | Cop Out | $26,282 | -60.1% | 36 | - | $730 | $127,984 | 2 | Warner Bros. | false | false |
| 8 | 3 | Sex and the City 2 | $22,942 | -67.2% | 53 | -4 | $432 | $860,261 | 4 | Warner Bros. | false | false |
| 9 | 5 | Killers | $19,033 | -71.8% | 38 | - | $500 | $241,532 | 3 | N/A | false | false |
| 10 | 7 | The A-Team | $16,661 | -70.8% | 50 | -4 | $333 | $202,671 | 3 | 20th Century Fox International | false | false |
| 11 | 9 | Avatar | $12,671 | -69.2% | 7 | +1 | $1,810 | $8,165,645 | 28 | 20th Century Fox International | false | false |
| 12 | 11 | Robin Hood | $743 | -83.2% | 23 | -23 | $32 | $1,434,534 | 7 | Universal Pictures International (UPI) | false | false |
| 13 | 12 | A Nightmare on Elm Street | $435 | -80% | 1 | -4 | $435 | $417,013 | 8 | Warner Bros. | false | false |
| 14 | 13 | The Back-up Plan | $93 | -92.1% | 3 | -5 | $31 | $399,375 | 8 | Sony Pictures Releasing | false | false |
