| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Date Night | $1,957,215 | - | 400 | - | $4,893 | $1,957,215 | 1 | 20th Century Fox International | true | false |
| 2 | 2 | Clash of the Titans | $1,515,657 | -36.7% | 450 | -11 | $3,368 | $27,796,494 | 4 | Warner Bros. | false | false |
| 3 | 3 | How to Train Your Dragon | $1,263,845 | -35.9% | 478 | -12 | $2,644 | $21,930,121 | 4 | Paramount Pictures International | false | false |
| 4 | 1 | Dear John | $1,249,461 | -59.3% | 415 | +13 | $3,010 | $5,501,597 | 2 | Paramount Pictures International | false | false |
| 5 | 4 | Kick-Ass | $977,173 | -30.2% | 414 | -10 | $2,360 | $15,753,042 | 4 | Universal Pictures International (UPI) | false | false |
| 6 | 6 | The Ghost Writer | $970,654 | -26% | 343 | +11 | $2,829 | $3,149,525 | 2 | Optimum Releasing | false | false |
| 7 | - | It's a Wonderful Afterlife | $714,445 | - | 294 | - | $2,430 | $714,445 | 4 | Icon Film Distribution | false | false |
| 8 | 5 | Nanny McPhee Returns | $611,237 | -54.1% | 497 | -14 | $1,229 | $23,333,453 | 5 | Universal Pictures International (UPI) | false | false |
| 9 | 8 | Alice in Wonderland | $428,935 | -44.1% | 365 | -45 | $1,175 | $64,474,975 | 8 | Walt Disney Pictures | false | false |
| 10 | - | The Joneses | $380,210 | - | 217 | - | $1,752 | $380,210 | 1 | Entertainment One | true | false |
| 11 | 7 | Cemetery Junction | $311,620 | -68.4% | 310 | -20 | $1,005 | $1,742,702 | 2 | Sony Pictures Releasing | false | false |
| 12 | 9 | The Blind Side | $201,740 | -56.1% | 212 | -108 | $951 | $9,127,125 | 5 | Warner Bros. | false | false |
| 13 | - | Centurion | $175,581 | - | 102 | - | $1,721 | $175,581 | 1 | Warner Bros. | true | false |
| 14 | 12 | Shutter Island | $126,894 | -53.9% | 134 | -59 | $946 | $16,304,568 | 7 | Paramount Pictures International | false | false |
| 15 | 10 | Remember Me | $109,006 | -68.5% | 191 | -153 | $570 | $5,494,638 | 4 | Entertainment One | false | false |
| 16 | 13 | The Infidel | $101,675 | -45% | 57 | +1 | $1,783 | $681,346 | 3 | Revolver Entertainment | false | false |
