| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Clash of the Titans | $2,133,330 | -50.2% | 525 | -8 | $4,063 | $7,833,547 | 2 | Warner Bros. | false | false |
| 2 | - | Weddings and Other Disasters | $1,516,023 | - | 302 | - | $5,019 | $1,516,023 | 1 | 01 Distribution | true | false |
| 3 | - | The Crazies | $703,623 | - | 283 | - | $2,486 | $703,623 | 1 | Medusa Distribuzione | true | false |
| 4 | 2 | The Ghost Writer | $559,291 | -44.8% | 288 | -64 | $1,941 | $3,805,360 | 3 | 01 Distribution | false | false |
| 5 | 4 | Basilicata Coast to Coast | $502,788 | -29.2% | 194 | -2 | $2,591 | $2,577,666 | 3 | Eagle Pictures | false | false |
| 6 | 3 | Green Zone | $373,153 | -50.5% | 214 | -81 | $1,743 | $3,231,149 | 3 | Medusa Distribuzione | false | false |
| 7 | 7 | How to Train Your Dragon | $291,212 | -45.3% | 197 | -39 | $1,478 | $7,369,592 | 5 | Universal Pictures International (UPI) | false | false |
| 8 | 5 | From Paris with Love | $283,796 | -51% | 179 | -71 | $1,585 | $1,073,923 | 2 | N/A | false | false |
| 9 | 6 | The Bounty Hunter | $268,165 | -50.8% | 165 | -68 | $1,625 | $2,067,366 | 3 | Sony Pictures Releasing | false | false |
| 10 | 8 | Life Is a Wonderful Thing | $221,346 | -57.8% | 116 | -104 | $1,908 | $6,061,842 | 4 | Medusa Distribuzione | false | false |
| 11 | 10 | Cell 211 | $162,028 | -49.4% | 139 | -34 | $1,165 | $636,289 | 2 | N/A | false | false |
| 12 | 9 | Happy Family | $156,928 | -56% | 91 | -65 | $1,724 | $5,972,772 | 5 | 01 Distribution | false | false |
| 13 | 11 | Loose Cannons | $119,632 | -43.8% | 50 | -28 | $2,392 | $10,692,431 | 7 | 01 Distribution | false | false |
| 14 | 15 | Departures | $87,390 | -22.2% | 42 | - | $2,080 | $406,001 | 3 | N/A | false | false |
| 15 | 18 | The Concert | $65,584 | +1.4% | 41 | - | $1,599 | $4,603,667 | 12 | BIM Distribuzione | false | false |
| 16 | 14 | Alice in Wonderland | $64,143 | -55.9% | 59 | -31 | $1,087 | $40,492,857 | 8 | Walt Disney Pictures | false | false |
| 17 | 13 | Fantastic Mr. Fox | $58,046 | -66.6% | 87 | -11 | $667 | $268,894 | 2 | 20th Century Fox International | false | false |
| 18 | 12 | I Love You Phillip Morris | $46,594 | -73.3% | 36 | -75 | $1,294 | $2,739,427 | 4 | Lucky Red | false | false |
| 19 | 17 | No One Knows About Persian Cats | $39,525 | -43% | 38 | - | $1,040 | $145,754 | 2 | BIM Distribuzione | false | false |
| 20 | 19 | Shutter Island | $34,212 | -43.4% | 17 | - | $2,012 | $9,605,777 | 8 | Medusa Distribuzione | false | false |
| 21 | 16 | It's Complicated | $32,671 | -58.4% | 21 | - | $1,555 | $5,113,572 | 6 | United International Pictures | false | false |
| 22 | 20 | Little Nicholas | $24,770 | -56.1% | 26 | - | $952 | $882,361 | 4 | BIM Distribuzione | false | false |
| 23 | - | Simon Konianski | $17,905 | - | 14 | - | $1,278 | $139,117 | 3 | Fandango | false | false |
| 24 | - | Invictus | $17,107 | - | 12 | - | $1,425 | $8,526,206 | 9 | Warner Bros. | false | false |
| 25 | - | Avatar | $13,933 | - | 10 | - | $1,393 | $88,825,829 | 15 | 20th Century Fox International | false | false |
| 26 | - | The Messenger | $13,569 | - | 24 | - | $565 | $78,366 | 2 | Lucky Red | false | false |
| 27 | - | A Prophet | $13,221 | - | 14 | - | $944 | $799,168 | 6 | BIM Distribuzione | false | false |
| 28 | - | La valigia sul letto | $10,824 | - | 4 | - | $2,706 | $763,063 | 7 | Medusa Distribuzione | false | false |
| 29 | - | Remember Me | $10,750 | - | 12 | - | $895 | $3,008,966 | 5 | Eagle Pictures | false | false |
| 30 | - | Extraordinary Measures | $10,174 | - | 12 | - | $847 | $10,174 | 1 | Sony Pictures Releasing | true | false |
| 31 | - | The Man Who Will Come | $7,133 | - | 8 | - | $891 | $1,616,871 | 14 | Mikado Film | false | false |
| 32 | - | Genitori & figli:) - Agitare bene prima dell'uso | $6,967 | - | 5 | - | $1,393 | $11,455,266 | 9 | Filmauro | false | false |
