| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Clash of the Titans | $122,695 | -8.3% | 9 | - | $13,632 | $278,676 | 2 | Warner Bros. | false | false |
| 2 | 2 | My Name Is Khan | $34,421 | +22.8% | 8 | - | $4,302 | $444,418 | 10 | 20th Century Fox International | false | false |
| 3 | 5 | How to Train Your Dragon | $26,221 | +37.2% | 8 | - | $3,277 | $132,615 | 4 | United International Pictures | false | false |
| 4 | 3 | Alice in Wonderland | $26,148 | +13.3% | 4 | - | $6,537 | $452,679 | 8 | Walt Disney Pictures | false | false |
| 5 | 4 | The Bounty Hunter | $21,165 | +0.9% | 6 | - | $3,527 | $184,204 | 5 | Sony Pictures Releasing | false | false |
| 6 | - | The Last Song | $17,743 | - | 3 | - | $5,914 | $17,743 | 1 | Walt Disney Pictures | true | false |
| 7 | 6 | Remember Me | $14,985 | +3.2% | 5 | - | $2,997 | $81,270 | 4 | - | false | false |
| 8 | - | Daybreakers | $14,608 | - | 5 | - | $2,921 | $14,608 | 1 | N/A | true | false |
| 9 | 7 | Shutter Island | $13,789 | +2.6% | 8 | -2 | $1,723 | $239,213 | 7 | United International Pictures | false | false |
| 10 | 8 | Avatar | $10,010 | +16% | 2 | - | $5,005 | $2,279,270 | 19 | 20th Century Fox International | false | false |
| 11 | 9 | From Paris with Love | $7,822 | -5.3% | 6 | -2 | $1,303 | $164,274 | 7 | N/A | false | false |
| 12 | 12 | When in Rome | $4,704 | +2.4% | 3 | - | $1,568 | $49,806 | 6 | Walt Disney Pictures | false | false |
| 13 | 11 | The Wolfman | $3,335 | -35.4% | 6 | -3 | $555 | $177,463 | 9 | United International Pictures | false | false |
| 14 | 20 | Stag Night | $3,104 | +436.1% | 3 | +2 | $1,034 | $39,744 | 9 | N/A | false | false |
| 15 | 13 | Pandorum | $3,026 | -10.3% | 5 | - | $605 | $30,171 | 4 | N/A | false | false |
| 16 | 10 | Green Zone | $2,976 | -57% | 8 | +7 | $372 | $117,952 | 6 | United International Pictures | false | false |
| 17 | 14 | The Book of Eli | $2,825 | -8.3% | 2 | -2 | $1,412 | $279,552 | 13 | - | false | false |
| 18 | 16 | Astro Boy | $1,147 | -44.7% | 2 | -1 | $573 | $3,531 | 2 | - | false | false |
| 19 | 21 | Alvin and the Chipmunks: The Squeakquel | $578 | +26.5% | 1 | - | $578 | $152,047 | 18 | 20th Century Fox International | false | false |
| 20 | 15 | Valentine's Day | $548 | -77.1% | 1 | -2 | $548 | $262,388 | 11 | Warner Bros. | false | false |
| 21 | 18 | The Lovely Bones | $441 | -62.7% | 4 | -4 | $110 | $28,574 | 5 | United International Pictures | false | false |
| 22 | 19 | It's Complicated | $167 | -83.4% | 2 | -1 | $83 | $123,927 | 12 | United International Pictures | false | false |
| 23 | 24 | The Princess and the Frog | $67 | -20.2% | 1 | - | $67 | $79,257 | 17 | Walt Disney Pictures | false | false |
