| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Clash of the Titans | $1,084,300 | - | 67 | - | $16,183 | $1,084,300 | 1 | Warner Bros. | true | false |
| 2 | 1 | How to Train Your Dragon | $102,731 | -52.3% | 59 | - | $1,741 | $1,379,936 | 4 | Paramount Pictures International | false | false |
| 3 | 4 | Case 39 | $43,917 | -53% | 34 | - | $1,291 | $175,325 | 2 | Paramount Pictures International | false | false |
| 4 | 2 | The Book of Eli | $38,033 | -62.1% | 23 | -1 | $1,653 | $169,263 | 2 | Sony Pictures Releasing | false | false |
| 5 | 3 | Legion | $37,126 | -61.4% | 22 | -5 | $1,687 | $426,719 | 3 | Sony Pictures Releasing | false | false |
| 6 | 5 | It's Complicated | $26,024 | -59.1% | 30 | - | $867 | $282,296 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | Alice in Wonderland | $16,423 | -71.8% | 53 | - | $309 | $1,804,458 | 7 | Walt Disney Pictures | false | false |
| 8 | 7 | The Blind Side | $13,850 | -58.7% | 18 | - | $769 | $297,258 | 4 | Warner Bros. | false | false |
| 9 | 9 | My Best Friend's Girl | $10,756 | -48.1% | 27 | - | $398 | $267,405 | 5 | N/A | false | false |
| 10 | 12 | Paris 36 | $6,341 | -39.5% | 5 | - | $1,268 | $21,129 | 2 | N/A | false | false |
| 11 | 8 | Let the Right One In | $3,987 | -84% | 15 | - | $265 | $118,347 | 3 | N/A | false | false |
| 12 | - | Avatar | $3,744 | - | 3 | - | $1,248 | $7,836,825 | 18 | 20th Century Fox International | false | false |
| 13 | 11 | Transsiberian | $3,476 | -67.7% | 6 | - | $579 | $19,127 | 2 | N/A | false | false |
| 14 | 13 | The Hurt Locker | $2,647 | -72.2% | 15 | - | $176 | $360,546 | 9 | N/A | false | false |
| 15 | 10 | Shutter Island | $1,772 | -85.6% | 32 | - | $55 | $550,164 | 6 | Paramount Pictures International | false | false |
| 16 | 14 | All About Steve | $1,458 | -77.9% | 21 | - | $69 | $148,844 | 6 | 20th Century Fox International | false | false |
| 17 | 15 | Edge of Darkness | $1,180 | -62.6% | 28 | - | $42 | $407,283 | 8 | Warner Bros. | false | false |
| 18 | 16 | Precious | $414 | -86.5% | 7 | - | $59 | $106,437 | 8 | N/A | false | false |
| 19 | 21 | The Stepfather | $306 | -74.6% | 1 | - | $306 | $125,209 | 14 | Sony Pictures Releasing | false | false |
| 20 | - | Astro Boy | $161 | - | 25 | - | $6 | $245,227 | 12 | N/A | false | false |
| 21 | 20 | Extraordinary Measures | $103 | -93.2% | 1 | -1 | $103 | $56,546 | 6 | Sony Pictures Releasing | false | false |
| 22 | 23 | The Box | $76 | -85.4% | 16 | - | $4 | $62,096 | 7 | N/A | false | false |
| 23 | 30 | Dan in Real Life | $56 | +12% | 12 | - | $4 | $94,641 | 46 | N/A | false | false |
