| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Clash of the Titans | $1,226,076 | - | 104 | - | $11,789 | $1,226,076 | 1 | Warner Bros. | true | false |
| 2 | 2 | Brother and Sister | $255,473 | -15.5% | 64 | +2 | $3,991 | $1,253,490 | 3 | Primer Plano Film Group | false | false |
| 3 | 1 | Alice in Wonderland | $161,747 | -47.9% | 93 | -62 | $1,739 | $7,653,810 | 7 | Walt Disney Pictures | false | false |
| 4 | 3 | How to Train Your Dragon | $115,757 | -45.7% | 109 | -16 | $1,061 | $1,486,140 | 4 | Paramount Pictures International | false | false |
| 5 | - | Love Happens | $74,218 | - | 32 | - | $2,319 | $74,218 | 1 | Distribution Company | true | false |
| 6 | 4 | Date Night | $71,606 | -46.4% | 44 | -1 | $1,627 | $239,245 | 2 | 20th Century Fox International | false | false |
| 7 | 5 | Shutter Island | $65,031 | -40.4% | 41 | -2 | $1,586 | $1,409,410 | 6 | Paramount Pictures International | false | false |
| 8 | 6 | Case 39 | $51,168 | -42.1% | 32 | - | $1,599 | $162,768 | 2 | Paramount Pictures International | false | false |
| 9 | 7 | Remember Me | $41,113 | -51.7% | 27 | -2 | $1,522 | $145,847 | 2 | Alfa Films | false | false |
| 10 | - | Dear John | $36,431 | - | 30 | - | $1,214 | $36,431 | 1 | Sony Pictures Releasing | true | false |
| 11 | - | The Box | $31,242 | - | 17 | - | $1,837 | $31,242 | 1 | Alfa Films | true | false |
| 12 | 8 | The Bounty Hunter | $22,297 | -69.9% | 29 | -14 | $768 | $304,759 | 3 | Sony Pictures Releasing | false | false |
| 13 | 13 | The Blind Side | $16,087 | -33% | 30 | - | $536 | $273,458 | 5 | Warner Bros. | false | false |
| 14 | 9 | The Book of Eli | $15,096 | -68.7% | 36 | -4 | $419 | $567,593 | 5 | Sony Pictures Releasing | false | false |
| 15 | 11 | Remembering the Children | $13,636 | -47.1% | 10 | - | $1,363 | $47,173 | 2 | Distribution Company | false | false |
| 16 | 14 | Seraphine | $13,282 | -18.1% | 6 | -3 | $2,213 | $72,712 | 3 | N/A | false | false |
| 17 | 15 | Avatar | $10,778 | -18.7% | 3 | -7 | $3,592 | $13,408,408 | 16 | 20th Century Fox International | false | false |
| 18 | 25 | The Rebound | $8,660 | +95.2% | 10 | -2 | $866 | $108,604 | 4 | Alfa Films | false | false |
| 19 | 12 | Edge of Darkness | $7,326 | -70.6% | 15 | -32 | $488 | $1,133,819 | 8 | Warner Bros. | false | false |
| 20 | 20 | Everybody's Fine | $5,068 | -19.1% | 12 | - | $422 | $175,667 | 5 | Walt Disney Pictures | false | false |
| 21 | 17 | Couples Retreat | $3,949 | -58.4% | 7 | -4 | $564 | $159,912 | 7 | Universal Pictures International (UPI) | false | false |
| 22 | 10 | The Fourth Kind | $3,802 | -87.6% | 10 | -15 | $380 | $137,131 | 3 | Alfa Films | false | false |
| 23 | 23 | Did You Hear About the Morgans? | $2,954 | -44.3% | 10 | -4 | $295 | $282,079 | 6 | Sony Pictures Releasing | false | false |
| 24 | 45 | Coco 2010 Re-release | $2,658 | +5,678.3% | 8 | +7 | $332 | $16,309 | 4 | Impacto Cine | false | false |
| 25 | 16 | Brothers | $2,550 | -78.2% | 11 | -20 | $231 | $132,579 | 4 | Distribution Company | false | false |
| 26 | 21 | Crazy Heart | $2,077 | -65.1% | 5 | -5 | $415 | $105,128 | 6 | 20th Century Fox International | false | false |
| 27 | 22 | Paco | $1,926 | -67.5% | 13 | +6 | $148 | $178,234 | 5 | Primer Plano Film Group | false | false |
| 28 | 19 | Precious | $1,742 | -74% | 8 | -3 | $217 | $295,170 | 10 | N/A | false | false |
| 29 | 30 | Bad Lieutenant: Port of Call New Orleans | $1,700 | +9.5% | 6 | - | $283 | $172,174 | 7 | Distribution Company | false | false |
| 30 | 18 | The Hurt Locker | $1,594 | -78.1% | 13 | -8 | $122 | $790,335 | 11 | Distribution Company | false | false |
| 31 | 38 | Birds of Paradise | $1,057 | +60.6% | 1 | -2 | $1,057 | $193,843 | 9 | Sony Pictures Releasing | false | false |
| 32 | 26 | The Girl with the Dragon Tattoo | $1,050 | -66.8% | 3 | -2 | $350 | $277,620 | 9 | N/A | false | false |
| 33 | 35 | The Secret in Their Eyes | $846 | -17.3% | 7 | - | $120 | $9,255,067 | 36 | Distribution Company | false | false |
| 34 | 29 | A Serious Man | $826 | -53.8% | 1 | -7 | $826 | $148,500 | 8 | Universal Pictures International (UPI) | false | false |
| 35 | 27 | Old Dogs | $657 | -74.2% | 3 | -6 | $219 | $1,508,990 | 13 | Walt Disney Pictures | false | false |
| 36 | 28 | The Wolfman | $596 | -72.2% | 4 | -3 | $149 | $1,120,580 | 10 | Universal Pictures International (UPI) | false | false |
| 37 | 41 | 9 | $534 | +75.7% | 5 | +3 | $106 | $36,736 | 5 | Distribution Company | false | false |
| 38 | 24 | Fame | $419 | -91.1% | 2 | -16 | $209 | $55,801 | 3 | Impacto Cine | false | false |
| 39 | 31 | Our Beloved Month of August | $371 | -68.2% | 3 | -1 | $123 | $39,335 | 7 | N/A | false | false |
| 40 | 34 | Valentine's Day | $337 | -67.4% | 3 | - | $112 | $884,176 | 10 | Warner Bros. | false | false |
| 41 | 42 | Zombieland | $85 | -71.9% | 1 | -1 | $85 | $107,716 | 12 | Sony Pictures Releasing | false | false |
| 42 | 46 | Astro Boy | $49 | +40% | 1 | - | $49 | $174,411 | 12 | Alfa Films | false | false |
| 43 | 33 | The Princess and the Frog | $36 | -96.5% | 1 | -3 | $36 | $1,921,247 | 15 | Walt Disney Pictures | false | false |
| 44 | 37 | Percy Jackson & the Olympians: The Lightning Thief | $34 | -95.9% | 1 | -6 | $34 | $723,425 | 9 | 20th Century Fox International | false | false |
