| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Clash of the Titans | $61,400,000 | $61,235,105 | -$164,895 | -0.3% | 3,777 | $64,055,000 | $63,890,110 | 1 | Warner Bros. | - |
| 2 | 2 | - | Why Did I Get Married Too? | $30,150,000 | $29,289,537 | -$860,463 | -2.9% | 2,155 | $30,150,000 | $29,289,537 | 1 | Lionsgate | - |
| 3 | 3 | - | How to Train Your Dragon | $29,200,000 | $29,010,044 | -$189,956 | -0.7% | 4,060 | - | $92,135,916 | 2 | DreamWorks | - |
| 4 | 4 | - | The Last Song | $16,203,000 | $16,007,426 | -$195,574 | -1.2% | 2,673 | $25,590,000 | $25,395,041 | 1 | Walt Disney Studios Motion Pictures | - |
| 5 | 5 | - | Alice in Wonderland | $8,267,000 | $8,208,060 | -$58,940 | -0.7% | 2,980 | $309,793,000 | $309,733,753 | 5 | Walt Disney Studios Motion Pictures | - |
| 6 | 6 | - | Hot Tub Time Machine | $8,000,000 | $8,070,716 | +$70,716 | +0.9% | 2,771 | $27,842,000 | $27,910,213 | 2 | Metro-Goldwyn-Mayer (MGM) | - |
| 7 | 7 | - | The Bounty Hunter | $6,200,000 | $6,091,907 | -$108,093 | -1.7% | 3,118 | $48,957,000 | $48,853,453 | 3 | Sony Pictures Releasing | - |
| 8 | 8 | - | Diary of a Wimpy Kid | $5,525,000 | $5,302,369 | -$222,631 | -4% | 2,842 | $46,234,000 | $46,013,347 | 3 | Twentieth Century Fox | - |
| 9 | 9 | - | She's Out of My League | $1,463,000 | $1,516,952 | +$53,952 | +3.7% | 1,390 | $28,659,000 | $28,712,974 | 4 | Paramount Pictures | - |
| 10 | 10 | - | Shutter Island | $1,462,000 | $1,488,403 | +$26,403 | +1.8% | 1,356 | $123,415,000 | $123,440,937 | 7 | Paramount Pictures | - |
| 11 | 11 | - | Green Zone | $1,217,000 | $1,248,395 | +$31,395 | +2.6% | 1,242 | $33,087,000 | $33,118,420 | 4 | Universal Pictures | - |
| 12 | 12 | - | The Ghost Writer | $1,135,000 | $1,127,697 | -$7,303 | -0.6% | 656 | $11,024,000 | $11,016,593 | 7 | Summit Entertainment | - |
| 13 | 13 | - | Avatar | $985,000 | $980,239 | -$4,761 | -0.5% | 511 | $742,340,000 | $742,332,678 | 16 | Twentieth Century Fox | - |
| 14 | 15 | +1 | Greenberg | $742,000 | $725,294 | -$16,706 | -2.3% | 186 | $2,311,000 | $2,293,918 | 3 | Focus Features | - |
| 15 | 14 | -1 | Our Family Wedding | $735,000 | $826,067 | +$91,067 | +12.4% | 722 | $18,519,000 | $18,602,225 | 4 | Fox Searchlight Pictures | - |
| 16 | 17 | +1 | Chloe | $584,000 | $512,871 | -$71,129 | -12.2% | 339 | $1,868,000 | $1,797,090 | 2 | Sony Pictures Classics | - |
| 17 | 16 | -1 | Repo Men | $528,000 | $576,180 | +$48,180 | +9.1% | 873 | $13,108,000 | $13,156,255 | 3 | Universal Pictures | - |
| 18 | 19 | +1 | The Girl with the Dragon Tattoo | $487,000 | $455,977 | -$31,023 | -6.4% | 87 | $1,470,000 | $1,438,838 | 3 | Music Box Films | - |
| 19 | 18 | -1 | Remember Me | $483,000 | $482,428 | -$572 | -0.1% | 906 | $18,243,000 | $18,242,661 | 4 | Summit Entertainment | - |
| 20 | 20 | - | Hubble | $418,000 | $435,516 | +$17,516 | +4.2% | 40 | - | $1,967,473 | 3 | Warner Bros. | - |
| 21 | 21 | - | Percy Jackson & the Olympians: The Lightning Thief | $345,000 | $323,050 | -$21,950 | -6.4% | 412 | $86,719,000 | $86,695,247 | 8 | Twentieth Century Fox | - |
| 22 | 22 | - | Crazy Heart | $325,000 | $321,014 | -$3,986 | -1.2% | 435 | $38,353,000 | $38,349,555 | 16 | Fox Searchlight Pictures | - |
| 23 | 24 | +1 | The Crazies | $262,000 | $256,394 | -$5,606 | -2.1% | 415 | $38,246,000 | $38,240,768 | 6 | Overture Films | - |
| 24 | 29 | +5 | The Runaways | $183,000 | $166,417 | -$16,583 | -9.1% | 84 | $1,972,000 | $1,955,954 | 3 | Apparition | - |
| 25 | 28 | +3 | Brooklyn's Finest | $162,000 | $173,783 | +$11,783 | +7.3% | 301 | $26,735,000 | $26,746,443 | 5 | Overture Films | - |
| 26 | 34 | +8 | A Prophet | $124,000 | $114,927 | -$9,073 | -7.3% | 83 | $1,524,000 | $1,515,303 | 6 | Sony Pictures Classics | - |
| 27 | 35 | +8 | The Last Station | $121,000 | $112,420 | -$8,580 | -7.1% | 128 | $6,225,000 | $6,216,606 | 12 | Sony Pictures Classics | - |
| 28 | 41 | +13 | The Secret of Kells | $57,500 | $56,508 | -$992 | -1.7% | 18 | $187,000 | $186,378 | 5 | GKIDS | - |
| 29 | 46 | +17 | The White Ribbon | $32,700 | $33,320 | +$620 | +1.9% | 53 | $2,076,000 | $2,077,054 | 14 | Sony Pictures Classics | - |
| 30 | 48 | +18 | A Single Man | $27,600 | $27,755 | +$155 | +0.6% | 71 | $9,099,000 | $9,098,668 | 17 | The Weinstein Company | - |
| 31 | 57 | +26 | Breaking Upwards | $15,300 | $15,467 | +$167 | +1.1% | 1 | $15,300 | $15,467 | 1 | IFC Films | - |
| 32 | 58 | +26 | Waking Sleeping Beauty | $14,800 | $15,224 | +$424 | +2.9% | 5 | $60,600 | $60,996 | 2 | Walt Disney Studios Motion Pictures | - |
