| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $284,688 | -44.9% | 130 | -3 | $2,189 | $6,489,014 | 6 | Walt Disney Pictures | false | false |
| 2 | 2 | How to Train Your Dragon | $240,852 | -37% | 2 | -113 | $120,426 | $1,455,979 | 3 | United International Pictures | false | false |
| 3 | - | Legion | $194,664 | - | 50 | - | $3,893 | $194,664 | 1 | Sony Pictures Releasing | true | false |
| 4 | 3 | The Book of Eli | $87,829 | -42.8% | 75 | - | $1,171 | $925,082 | 4 | Sony Pictures Releasing | false | false |
| 5 | - | Case 39 | $64,644 | - | 35 | - | $1,846 | $64,644 | 1 | United International Pictures | true | false |
| 6 | 4 | The Blind Side | $51,516 | -39% | 43 | -3 | $1,198 | $346,470 | 3 | Warner Bros. | false | false |
| 7 | 7 | Shutter Island | $29,440 | -41.6% | 27 | +2 | $1,090 | $429,584 | 5 | United International Pictures | false | false |
| 8 | 6 | Avatar | $23,310 | -53.9% | 10 | -2 | $2,331 | $13,620,596 | 17 | 20th Century Fox International | false | false |
| 9 | 5 | Did You Hear About the Morgans? | $20,009 | -71.7% | 43 | -7 | $465 | $273,166 | 3 | Sony Pictures Releasing | false | false |
| 10 | - | Mongol: The Rise of Genghis Khan | $18,272 | - | 9 | - | $2,030 | $18,272 | 1 | Cine Colombia | true | false |
| 11 | 8 | Remember Me | $14,395 | -63.8% | 23 | -7 | $625 | $156,860 | 3 | Cine Colombia | false | false |
| 12 | 9 | Edge of Darkness | $11,928 | -61.9% | 23 | -14 | $518 | $442,179 | 5 | Warner Bros. | false | false |
| 13 | 11 | The Hurt Locker | $6,288 | -42.6% | 10 | - | $628 | $242,677 | 9 | Cineplex | false | false |
| 14 | 12 | [Rec]² | $5,355 | -49.3% | 12 | +2 | $446 | $243,171 | 6 | Cine Colombia | false | false |
| 15 | 10 | Percy Jackson & the Olympians: The Lightning Thief | $4,938 | -57.9% | 13 | -9 | $379 | $869,135 | 9 | 20th Century Fox International | false | false |
| 16 | 14 | Old Dogs | $4,292 | -32.4% | 5 | -1 | $858 | $1,183,744 | 14 | Walt Disney Pictures | false | false |
| 17 | - | Away We Go | $4,096 | - | 5 | - | $819 | $4,096 | 1 | United International Pictures | true | false |
| 18 | 15 | The Anarchist's Wife | $3,741 | -39.7% | 4 | - | $935 | $24,604 | 3 | Cineplex | false | false |
| 19 | 13 | Tooth Fairy | $2,846 | -70.5% | 10 | -9 | $284 | $1,134,386 | 12 | 20th Century Fox International | false | false |
| 20 | 17 | Couples Retreat | $2,700 | -40.4% | 4 | - | $675 | $220,881 | 7 | United International Pictures | false | false |
| 21 | 16 | The Wolfman | $2,475 | -55.3% | 4 | - | $618 | $1,045,872 | 9 | United International Pictures | false | false |
| 22 | 24 | A Prophet | $1,714 | +3.2% | 3 | - | $571 | $14,529 | 4 | Sony Pictures Releasing | false | false |
| 23 | 22 | The White Ribbon | $1,284 | -29.3% | 2 | - | $642 | $33,501 | 6 | - | false | false |
| 24 | 20 | Precious | $907 | -61.2% | 3 | -2 | $302 | $299,090 | 8 | Cine Colombia | false | false |
| 25 | 25 | A Serious Man | $893 | -23.7% | 2 | - | $446 | $11,406 | 4 | United International Pictures | false | false |
| 26 | 19 | Law Abiding Citizen | $876 | -62.9% | 4 | +1 | $219 | $280,414 | 7 | Cineplex | false | false |
| 27 | 18 | Everybody's Fine | $616 | -82.2% | 2 | -12 | $308 | $64,836 | 5 | Walt Disney Pictures | false | false |
| 28 | 21 | The Imaginarium of Doctor Parnassus | $163 | -92.8% | 1 | -1 | $163 | $65,367 | 6 | Sony Pictures Releasing | false | false |
