| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Alice in Wonderland | $34,500,000 | $34,189,969 | -$310,031 | -0.9% | 3,739 | $265,800,000 | $265,433,637 | 3 | Walt Disney Studios Motion Pictures | - |
| 2 | 2 | - | Diary of a Wimpy Kid | $21,800,000 | $22,126,166 | +$326,166 | +1.5% | 3,077 | $21,800,000 | $22,126,166 | 1 | Twentieth Century Fox | - |
| 3 | 3 | - | The Bounty Hunter | $21,000,000 | $20,686,423 | -$313,577 | -1.5% | 3,074 | $21,000,000 | $20,686,423 | 1 | Sony Pictures Releasing | - |
| 4 | 4 | - | Repo Men | $6,151,000 | $6,126,170 | -$24,830 | -0.4% | 2,521 | $6,151,000 | $6,126,170 | 1 | Universal Pictures | - |
| 5 | 6 | +1 | She's Out of My League | $6,015,000 | $5,802,363 | -$212,637 | -3.5% | 2,958 | $19,954,000 | $19,741,174 | 2 | Paramount Pictures | - |
| 6 | 5 | -1 | Green Zone | $5,963,000 | $6,113,105 | +$150,105 | +2.5% | 3,004 | $24,702,000 | $24,852,135 | 2 | Universal Pictures | - |
| 7 | 7 | - | Shutter Island | $4,755,000 | $4,735,834 | -$19,166 | -0.4% | 2,704 | $115,770,000 | $115,750,466 | 5 | Paramount Pictures | - |
| 8 | 8 | - | Avatar | $4,000,000 | $4,027,005 | +$27,005 | +0.7% | 1,236 | $736,881,000 | $736,907,957 | 14 | Twentieth Century Fox | - |
| 9 | 9 | - | Our Family Wedding | $3,800,000 | $3,739,600 | -$60,400 | -1.6% | 1,609 | $13,668,000 | $13,608,107 | 2 | Fox Searchlight Pictures | - |
| 10 | 10 | - | Remember Me | $3,300,000 | $3,252,494 | -$47,506 | -1.4% | 2,215 | $13,900,000 | $13,918,922 | 2 | Summit Entertainment | - |
| 11 | 11 | - | The Ghost Writer | $2,100,000 | $2,063,595 | -$36,405 | -1.7% | 819 | $6,800,000 | $6,753,764 | 5 | Summit Entertainment | - |
| 12 | 12 | - | Brooklyn's Finest | $1,679,000 | $1,640,703 | -$38,297 | -2.3% | 1,311 | $24,859,000 | $24,821,335 | 3 | Overture Films | - |
| 13 | 13 | - | The Crazies | $1,502,000 | $1,488,933 | -$13,067 | -0.9% | 1,495 | $36,409,000 | $36,396,873 | 4 | Overture Films | - |
| 14 | 14 | - | Cop Out | $1,410,000 | $1,417,365 | +$7,365 | +0.5% | 1,563 | $42,564,000 | $42,571,478 | 4 | Warner Bros. | - |
| 15 | 15 | - | Crazy Heart | $1,375,000 | $1,395,387 | +$20,387 | +1.5% | 1,154 | $36,409,000 | $36,430,281 | 14 | Fox Searchlight Pictures | - |
| 16 | 16 | - | Percy Jackson & the Olympians: The Lightning Thief | $1,350,000 | $1,368,470 | +$18,470 | +1.4% | 1,348 | $85,020,000 | $85,038,766 | 6 | Twentieth Century Fox | - |
| 17 | 17 | - | The Blind Side | $925,000 | $877,736 | -$47,264 | -5.1% | 602 | $254,321,000 | $254,273,981 | 18 | Warner Bros. | - |
| 18 | 18 | - | The Runaways | $803,000 | $805,115 | +$2,115 | +0.3% | 244 | $803,000 | $805,115 | 1 | Apparition | - |
| 19 | 19 | - | Hubble | $453,000 | $413,477 | -$39,523 | -8.7% | 39 | - | $413,477 | 1 | Warner Bros. | - |
| 20 | 20 | - | The Hurt Locker | $412,000 | - | - | - | 320 | $16,400,000 | - | 39 | Summit Entertainment | - |
| 21 | 22 | +1 | Alvin and the Chipmunks: The Squeakquel | $400,000 | $378,542 | -$21,458 | -5.4% | 380 | $218,663,000 | $218,641,790 | 13 | Twentieth Century Fox | - |
| 22 | 24 | +2 | The Last Station | $281,000 | $261,509 | -$19,491 | -6.9% | 226 | $5,737,000 | $5,718,005 | 10 | Sony Pictures Classics | - |
| 23 | 25 | +2 | Tooth Fairy | $260,000 | $261,113 | +$1,113 | +0.4% | 372 | $57,957,000 | $57,958,558 | 9 | Twentieth Century Fox | - |
| 24 | 28 | +4 | A Prophet | $206,000 | $207,458 | +$1,458 | +0.7% | 77 | $1,088,000 | $1,089,225 | 4 | Sony Pictures Classics | - |
| 25 | 29 | +4 | The Wolfman | $169,000 | $153,675 | -$15,325 | -9.1% | 218 | $61,792,000 | $61,776,925 | 6 | Universal Pictures | - |
| 26 | 32 | +6 | Up in the Air | $108,000 | $107,709 | -$291 | -0.3% | 178 | $83,676,000 | $83,675,267 | 16 | Paramount Pictures | - |
| 27 | 33 | +6 | It's Complicated | $94,000 | $102,200 | +$8,200 | +8.7% | 145 | $112,574,000 | $112,583,115 | 13 | Universal Pictures | - |
| 28 | 38 | +10 | An Education | $86,100 | $70,769 | -$15,331 | -17.8% | 117 | $12,456,100 | $12,440,758 | 24 | Sony Pictures Classics | - |
| 29 | 37 | +8 | A Single Man | $75,000 | $73,766 | -$1,234 | -1.6% | 90 | $8,966,000 | $8,964,864 | 15 | The Weinstein Company | - |
| 30 | 43 | +13 | The Twilight Saga: New Moon | $65,000 | $52,472 | -$12,528 | -19.3% | 145 | $296,605,600 | $296,593,070 | 18 | Summit Entertainment | - |
| 31 | 44 | +13 | The White Ribbon | $48,900 | $48,819 | -$81 | -0.2% | 59 | $1,957,100 | $1,957,029 | 12 | Sony Pictures Classics | - |
| 32 | 47 | +15 | City Island | $35,000 | $32,001 | -$2,999 | -8.6% | 2 | $35,000 | $32,001 | 1 | Anchor Bay Films | - |
| 33 | 49 | +16 | Broken Embraces | $27,100 | $26,433 | -$667 | -2.5% | 37 | $4,727,300 | $4,726,606 | 18 | Sony Pictures Classics | - |
| 34 | 55 | +21 | The Secret of Kells | $19,500 | $19,787 | +$287 | +1.5% | 6 | $90,600 | $90,911 | 3 | GKIDS | - |
| 35 | 61 | +26 | My Name Is Khan | $19,400 | $18,155 | -$1,245 | -6.4% | 25 | $3,976,400 | $3,975,090 | 6 | Fox Searchlight Pictures | - |
| 36 | 66 | +30 | The Imaginarium of Doctor Parnassus | $13,800 | $12,707 | -$1,093 | -7.9% | 33 | $7,569,100 | $7,566,622 | 13 | Sony Pictures Classics | - |
| 37 | 68 | +31 | The Messenger | $10,100 | $10,989 | +$889 | +8.8% | 17 | $1,056,800 | $1,057,706 | 19 | Oscilloscope | - |
| 38 | 69 | +31 | Preacher's Kid | $7,700 | $10,725 | +$3,025 | +39.3% | 25 | $498,800 | $501,851 | 8 | 8x Entertainment | - |
| 39 | 75 | +36 | Youth in Revolt | $6,000 | $5,978 | -$22 | -0.4% | 26 | $15,281,000 | $15,281,286 | 11 | Dimension Films | - |
| 40 | 83 | +43 | The Road | $3,000 | - | - | - | 7 | $8,117,000 | - | 17 | Dimension Films | - |
| 41 | 98 | +57 | The Exploding Girl | $1,400 | $1,209 | -$191 | -13.6% | 1 | $10,100 | $9,939 | 2 | Oscilloscope | - |
| 42 | 100 | +58 | Terribly Happy | $1,100 | $1,117 | +$17 | +1.5% | 2 | $99,900 | $99,947 | 7 | Oscilloscope | - |
