| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $1,059,285 | -30.5% | 172 | +1 | $6,158 | $5,797,248 | 3 | Walt Disney Pictures | false | false |
| 2 | 2 | Dear John | $265,785 | -21.1% | 81 | - | $3,281 | $1,241,915 | 3 | A-Film Distribution | false | false |
| 3 | 3 | Avatar | $203,504 | -28% | 51 | -10 | $3,990 | $24,482,517 | 15 | 20th Century Fox International | false | false |
| 4 | 4 | From Paris with Love | $189,432 | -26.2% | 70 | - | $2,706 | $547,463 | 2 | Entertainment One | false | false |
| 5 | - | Nanny McPhee Returns | $187,833 | - | 99 | - | $1,897 | $216,648 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | - | The Girl Who Kicked the Hornet's Nest | $139,763 | - | 40 | - | $3,494 | $164,226 | 1 | Benelux Film Distributors | true | false |
| 7 | 5 | Shutter Island | $133,301 | -18.7% | 51 | -1 | $2,613 | $2,219,228 | 6 | Universal Pictures International (UPI) | false | false |
| 8 | 6 | The Book of Eli | $85,163 | -27.5% | 55 | +1 | $1,548 | $869,194 | 4 | Paradiso Entertainment | false | false |
| 9 | - | First Mission | $74,576 | - | 59 | - | $1,264 | $78,147 | 1 | A-Film Distribution | true | false |
| 10 | - | Solomon Kane | $72,042 | - | 20 | - | $3,602 | $98,309 | 1 | Entertainment One | true | false |
| 11 | 7 | Cloudy with a Chance of Meatballs | $52,212 | -48% | 64 | -18 | $815 | $2,378,506 | 6 | Sony Pictures Releasing | false | false |
| 12 | 11 | Case 39 | $45,965 | -24.8% | 19 | -1 | $2,419 | $131,395 | 2 | Universal Pictures International (UPI) | false | false |
| 13 | 8 | Eep! 2010 Re-release | $41,041 | -48.1% | 90 | - | $456 | $1,580,272 | 6 | Independent Films | false | false |
| 14 | 10 | Gangsterboys | $38,395 | -39.6% | 33 | -6 | $1,163 | $1,376,961 | 6 | Independent Films | false | false |
| 15 | 9 | The Princess and the Frog | $35,134 | -45% | 102 | -4 | $344 | $2,938,273 | 8 | Walt Disney Pictures | false | false |
| 16 | 13 | Invictus | $34,971 | -31.7% | 25 | -3 | $1,398 | $354,763 | 4 | Warner Bros. | false | false |
| 17 | 17 | A Single Man | $28,942 | -28.6% | 20 | - | $1,447 | $763,643 | 8 | Cinéart | false | false |
| 18 | 12 | Bad Lieutenant: Port of Call New Orleans | $28,376 | -47.8% | 25 | -12 | $1,135 | $250,905 | 3 | Benelux Film Distributors | false | false |
| 19 | 18 | The Road | $26,625 | -32.1% | 17 | - | $1,566 | $86,803 | 2 | Benelux Film Distributors | false | false |
| 20 | 16 | Chloe | $24,033 | -41.4% | 22 | -16 | $1,092 | $306,709 | 4 | Universal Pictures International (UPI) | false | false |
| 21 | - | Crazy Heart | $10,318 | - | 5 | - | $2,063 | $10,318 | 1 | Warner Bros. | true | false |
| 22 | - | The Messenger | $4,117 | - | 3 | - | $1,372 | $4,117 | 1 | Entertainment One | true | false |
