| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $303,338 | -23.9% | 53 | - | $5,723 | $1,674,082 | 3 | Walt Disney Pictures | false | false |
| 2 | - | The Book of Eli | $56,680 | - | 23 | - | $2,464 | $56,680 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | The Blind Side | $24,762 | -28.8% | 13 | - | $1,904 | $77,218 | 2 | - | false | false |
| 4 | 3 | Armored | $19,343 | -34.6% | 19 | -3 | $1,018 | $69,405 | 2 | Sony Pictures Releasing | false | false |
| 5 | 5 | Old Dogs | $10,018 | -47.4% | 25 | -1 | $400 | $622,894 | 6 | Walt Disney Pictures | false | false |
| 6 | - | Nine | $9,091 | - | 6 | - | $1,515 | $39,603 | 8 | Sony Pictures Releasing | false | false |
| 7 | 4 | Percy Jackson & the Olympians: The Lightning Thief | $8,507 | -56% | 13 | -8 | $654 | $560,923 | 6 | 20th Century Fox International | false | false |
| 8 | - | Broken Embraces | $5,467 | - | 6 | - | $911 | $5,467 | 1 | United International Pictures | true | false |
| 9 | 8 | Avatar | $5,122 | -40.3% | 6 | - | $853 | $2,688,596 | 14 | 20th Century Fox International | false | false |
| 10 | 10 | The Salvation Poem | $3,375 | -51.3% | 3 | -1 | $1,125 | $119,734 | 5 | N/A | false | false |
| 11 | 13 | The Stepfather | $3,285 | -4.8% | 12 | -3 | $273 | $91,193 | 4 | Sony Pictures Releasing | false | false |
| 12 | 14 | The Secret in Their Eyes | $3,031 | +41.6% | 3 | +1 | $1,010 | $30,367 | 5 | N/A | false | false |
| 13 | 12 | Tooth Fairy | $2,857 | -39.8% | 3 | -11 | $952 | $702,632 | 8 | 20th Century Fox International | false | false |
| 14 | 6 | Funny People | $2,622 | -82.5% | 15 | - | $174 | $63,149 | 3 | United International Pictures | false | false |
| 15 | 11 | A Boyfriend for My Wife | $2,498 | -51.1% | 6 | - | $416 | $54,497 | 20 | - | false | false |
| 16 | 9 | Ninja Assassin | $1,909 | -76.2% | 9 | - | $212 | $33,038 | 3 | - | false | false |
| 17 | 7 | Cirque du Freak: The Vampire's Assistant | $1,367 | -85.9% | 13 | -8 | $105 | $137,544 | 4 | United International Pictures | false | false |
| 18 | - | Everybody's Fine | $1,248 | - | 1 | - | $1,248 | $72,850 | 8 | Walt Disney Pictures | false | false |
