| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Alice in Wonderland | $62,000,000 | $62,714,076 | +$714,076 | +1.2% | 3,728 | $208,625,000 | $209,339,432 | 2 | Walt Disney Studios Motion Pictures | - |
| 2 | 2 | - | Green Zone | $14,535,000 | $14,309,295 | -$225,705 | -1.6% | 3,003 | $14,535,000 | $14,309,295 | 1 | Universal Pictures | - |
| 3 | 3 | - | She's Out of My League | $9,600,000 | $9,775,278 | +$175,278 | +1.8% | 2,956 | $9,600,000 | $9,775,278 | 1 | Paramount Pictures | - |
| 4 | 5 | +1 | Remember Me | $8,300,000 | $8,089,139 | -$210,861 | -2.5% | 2,212 | $8,300,000 | $8,089,139 | 1 | Summit Entertainment | - |
| 5 | 4 | -1 | Shutter Island | $8,140,000 | $8,144,133 | +$4,133 | <0.1% | 3,356 | $108,008,000 | $108,011,645 | 4 | Paramount Pictures | - |
| 6 | 6 | - | Our Family Wedding | $7,600,000 | $7,629,862 | +$29,862 | +0.4% | 1,605 | $7,600,000 | $7,629,862 | 1 | Fox Searchlight Pictures | - |
| 7 | 7 | - | Avatar | $6,600,000 | $6,526,421 | -$73,579 | -1.1% | 1,718 | $730,344,000 | $730,270,443 | 13 | Twentieth Century Fox | - |
| 8 | 8 | - | Brooklyn's Finest | $4,290,000 | $4,471,932 | +$181,932 | +4.2% | 1,939 | $21,351,000 | $21,533,404 | 2 | Overture Films | - |
| 9 | 9 | - | Cop Out | $4,230,000 | $4,268,068 | +$38,068 | +0.9% | 2,882 | $39,442,000 | $39,480,734 | 3 | Warner Bros. | - |
| 10 | 10 | - | The Crazies | $3,650,000 | $3,680,940 | +$30,940 | +0.8% | 2,359 | $33,358,000 | $33,389,308 | 3 | Overture Films | - |
| 11 | 11 | - | Percy Jackson & the Olympians: The Lightning Thief | $3,125,000 | $3,077,631 | -$47,369 | -1.5% | 2,175 | $82,318,000 | $82,270,631 | 5 | Twentieth Century Fox | - |
| 12 | 12 | - | Crazy Heart | $3,125,000 | $3,005,547 | -$119,453 | -3.8% | 1,361 | $34,203,000 | $34,083,652 | 13 | Fox Searchlight Pictures | - |
| 13 | 13 | - | The Blind Side | $1,560,000 | $1,604,096 | +$44,096 | +2.8% | 803 | $252,692,000 | $252,736,267 | 17 | Warner Bros. | - |
| 14 | 14 | - | Valentine's Day | $1,500,000 | $1,449,339 | -$50,661 | -3.4% | 1,703 | $108,943,000 | $108,892,926 | 5 | Warner Bros. | - |
| 15 | 15 | - | The Ghost Writer | $1,231,000 | $1,225,084 | -$5,916 | -0.5% | 224 | $4,267,000 | $4,264,077 | 4 | Summit Entertainment | - |
| 16 | 17 | +1 | The Hurt Locker | $828,000 | - | - | - | 349 | $15,700,000 | - | 38 | Summit Entertainment | - |
| 17 | 18 | +1 | Tooth Fairy | $700,000 | $685,294 | -$14,706 | -2.1% | 737 | $57,260,000 | $57,246,089 | 8 | Twentieth Century Fox | - |
| 18 | 20 | +2 | The Last Station | $466,000 | $442,600 | -$23,400 | -5% | 272 | $5,316,000 | $5,292,337 | 9 | Sony Pictures Classics | - |
| 19 | 21 | +2 | The Wolfman | $393,000 | $404,630 | +$11,630 | +3% | 550 | $61,442,000 | $61,453,000 | 5 | Universal Pictures | - |
| 20 | 22 | +2 | Up in the Air | $277,000 | $265,305 | -$11,695 | -4.2% | 274 | $83,477,000 | $83,465,355 | 15 | Paramount Pictures | - |
| 21 | 26 | +5 | It's Complicated | $223,000 | $201,110 | -$21,890 | -9.8% | 221 | $112,417,000 | $112,394,750 | 12 | Universal Pictures | - |
| 22 | 25 | +3 | A Prophet | $218,000 | $226,866 | +$8,866 | +4.1% | 60 | $786,000 | $794,635 | 3 | Sony Pictures Classics | - |
| 23 | 29 | +6 | A Single Man | $157,000 | $160,917 | +$3,917 | +2.5% | 153 | $8,820,000 | $8,823,998 | 14 | The Weinstein Company | - |
| 24 | 30 | +6 | An Education | $152,000 | $149,270 | -$2,730 | -1.8% | 135 | $12,320,000 | $12,316,617 | 23 | Sony Pictures Classics | - |
| 25 | 32 | +7 | The Twilight Saga: New Moon | $115,000 | $113,956 | -$1,044 | -0.9% | 195 | $296,483,000 | $296,482,320 | 17 | Summit Entertainment | - |
| 26 | 34 | +8 | The Lovely Bones | $92,000 | $93,000 | +$1,000 | +1.1% | 188 | $43,982,000 | $43,982,842 | 14 | DreamWorks | - |
| 27 | 36 | +9 | The White Ribbon | $85,800 | $83,996 | -$1,804 | -2.1% | 90 | $1,865,400 | $1,863,573 | 11 | Sony Pictures Classics | - |
| 28 | 39 | +11 | Precious | $70,000 | $65,502 | -$4,498 | -6.4% | 115 | $47,540,000 | $47,536,959 | 19 | Lionsgate | - |
| 29 | 44 | +15 | My Name Is Khan | $57,000 | $62,565 | +$5,565 | +9.8% | 59 | $3,925,800 | $3,931,456 | 5 | Fox Searchlight Pictures | - |
| 30 | 54 | +24 | Youth in Revolt | $29,000 | $31,120 | +$2,120 | +7.3% | 90 | $15,252,000 | $15,253,974 | 10 | Dimension Films | - |
| 31 | 56 | +25 | Broken Embraces | $21,400 | $21,572 | +$172 | +0.8% | 40 | $4,689,000 | $4,689,155 | 17 | Sony Pictures Classics | - |
| 32 | 58 | +26 | The Imaginarium of Doctor Parnassus | $16,100 | $18,726 | +$2,626 | +16.3% | 38 | $7,541,800 | $7,544,348 | 12 | Sony Pictures Classics | - |
| 33 | 60 | +27 | The Messenger | $15,841 | $15,489 | -$352 | -2.2% | 22 | $1,022,496 | $1,035,320 | 18 | Oscilloscope | - |
| 34 | 64 | +30 | Creation | $11,300 | $11,300 | $0 | - | 6 | $266,800 | $266,800 | 8 | Newmarket Films | - |
| 35 | 62 | +27 | The Secret of Kells | $10,300 | $12,537 | +$2,237 | +21.7% | 1 | $64,838 | $67,040 | 2 | GKIDS | - |
| 36 | 72 | +36 | The Exploding Girl | $6,000 | $5,910 | -$90 | -1.5% | 1 | $6,000 | $5,910 | 1 | Oscilloscope | - |
| 37 | 78 | +41 | Terribly Happy | $4,148 | $3,759 | -$389 | -9.4% | 3 | $97,716 | $97,327 | 6 | Oscilloscope | - |
| 38 | 79 | +41 | Nine | $2,800 | $3,161 | +$361 | +12.9% | 14 | $19,673,000 | $19,673,424 | 13 | The Weinstein Company | - |
| 39 | 83 | +44 | The Road | $2,600 | $2,446 | -$154 | -5.9% | 10 | $8,112,000 | $8,111,216 | 16 | Dimension Films | - |
| 40 | 86 | +46 | Preacher's Kid | $1,400 | $1,596 | +$196 | +14% | 7 | $487,600 | $487,787 | 7 | 8x Entertainment | - |
