| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $1,523,063 | -12.8% | 171 | +2 | $8,906 | $4,443,180 | 2 | Walt Disney Pictures | false | false |
| 2 | 3 | Dear John | $336,749 | -11% | 81 | - | $4,157 | $906,568 | 2 | A-Film Distribution | false | false |
| 3 | 2 | Avatar | $282,669 | -27.2% | 61 | -11 | $4,633 | $24,490,359 | 14 | 20th Century Fox International | false | false |
| 4 | - | From Paris with Love | $256,657 | - | 70 | - | $3,666 | $290,123 | 1 | Entertainment One | true | false |
| 5 | 4 | Shutter Island | $163,925 | -32.3% | 52 | - | $3,152 | $2,068,276 | 5 | Universal Pictures International (UPI) | false | false |
| 6 | 5 | The Book of Eli | $117,413 | -39.5% | 54 | - | $2,174 | $758,677 | 3 | Paradiso Entertainment | false | false |
| 7 | 6 | Cloudy with a Chance of Meatballs | $100,314 | -24.5% | 82 | - | $1,223 | $2,341,124 | 5 | Sony Pictures Releasing | false | false |
| 8 | 7 | Eep! 2010 Re-release | $79,145 | -28.4% | 90 | - | $879 | $1,546,457 | 5 | Independent Films | false | false |
| 9 | 12 | The Princess and the Frog | $63,902 | -23% | 106 | -3 | $602 | $2,932,299 | 7 | Walt Disney Pictures | false | false |
| 10 | 8 | Gangsterboys | $63,602 | -40.1% | 39 | - | $1,630 | $1,340,220 | 5 | Independent Films | false | false |
| 11 | - | Case 39 | $61,117 | - | 20 | - | $3,055 | $64,815 | 1 | Universal Pictures International (UPI) | true | false |
| 12 | 10 | Bad Lieutenant: Port of Call New Orleans | $54,330 | -44.1% | 37 | - | $1,468 | $208,733 | 2 | Benelux Film Distributors | false | false |
| 13 | 13 | Invictus | $51,183 | -36.3% | 28 | +1 | $1,827 | $307,854 | 3 | Warner Bros. | false | false |
| 14 | 11 | The Lovely Bones | $49,618 | -47.8% | 49 | -5 | $1,012 | $760,157 | 4 | Universal Pictures International (UPI) | false | false |
| 15 | 9 | Valentine's Day | $44,231 | -54.8% | 67 | -28 | $660 | $3,320,832 | 6 | Warner Bros. | false | false |
| 16 | 14 | Chloe | $41,033 | -43.7% | 38 | -1 | $1,079 | $273,090 | 3 | Universal Pictures International (UPI) | false | false |
| 17 | 16 | A Single Man | $40,528 | -26.7% | 20 | - | $2,026 | $728,863 | 7 | Cinéart | false | false |
| 18 | - | The Road | $39,215 | - | 17 | - | $2,306 | $47,485 | 1 | Benelux Film Distributors | true | false |
| 19 | 17 | Alvin and the Chipmunks: The Squeakquel | $36,899 | -25.5% | 85 | -8 | $434 | $7,077,813 | 13 | Warner Bros. | false | false |
| 20 | 15 | Percy Jackson & the Olympians: The Lightning Thief | $29,969 | -55.7% | 58 | -19 | $516 | $1,923,665 | 6 | Warner Bros. | false | false |
| 21 | - | Gainsbourg: A Heroic Life | $18,909 | - | 12 | - | $1,575 | $18,909 | 1 | N/A | true | false |
| 22 | - | Lebanon | $17,323 | - | 16 | - | $1,082 | $17,323 | 1 | N/A | true | false |
| 23 | - | Escaping Tel Aviv | $9,017 | - | 3 | - | $3,005 | $9,017 | 1 | N/A | true | false |
