| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Alice in Wonderland | $116,300,000 | $116,101,023 | -$198,977 | -0.2% | 3,728 | $116,300,000 | $116,101,023 | 1 | Walt Disney Studios Motion Pictures | - |
| 2 | 2 | - | Brooklyn's Finest | $13,500,000 | $13,350,299 | -$149,701 | -1.1% | 1,936 | $13,500,000 | $13,350,299 | 1 | Overture Films | - |
| 3 | 3 | - | Shutter Island | $13,300,000 | $13,225,411 | -$74,589 | -0.6% | 3,178 | $95,825,000 | $95,750,005 | 3 | Paramount Pictures | - |
| 4 | 4 | - | Cop Out | $9,145,000 | $9,289,311 | +$144,311 | +1.6% | 3,150 | $32,360,000 | $32,504,610 | 2 | Warner Bros. | - |
| 5 | 5 | - | Avatar | $7,700,000 | $8,118,102 | +$418,102 | +5.4% | 2,163 | $720,189,000 | $720,607,444 | 12 | Twentieth Century Fox | - |
| 6 | 6 | - | The Crazies | $7,016,000 | $7,078,851 | +$62,851 | +0.9% | 2,479 | $27,409,000 | $27,472,164 | 2 | Overture Films | - |
| 7 | 7 | - | Percy Jackson & the Olympians: The Lightning Thief | $5,100,000 | $5,124,623 | +$24,623 | +0.5% | 2,994 | $78,033,000 | $78,057,749 | 4 | Twentieth Century Fox | - |
| 8 | 8 | - | Valentine's Day | $4,270,000 | $4,154,110 | -$115,890 | -2.7% | 3,040 | $106,420,000 | $106,303,870 | 4 | Warner Bros. | - |
| 9 | 9 | - | Crazy Heart | $3,350,000 | $3,312,591 | -$37,409 | -1.1% | 1,274 | $29,569,000 | $29,532,002 | 12 | Fox Searchlight Pictures | - |
| 10 | 10 | - | Dear John | $2,850,000 | $2,782,079 | -$67,921 | -2.4% | 2,496 | $76,694,000 | $76,626,086 | 5 | Screen Gems | - |
| 11 | 11 | - | Tooth Fairy | $2,800,000 | $1,684,408 | -$1,115,592 | -39.8% | 1,734 | $56,230,000 | $56,240,055 | 7 | Twentieth Century Fox | - |
| 12 | 13 | +1 | The Ghost Writer | $1,300,000 | $1,287,646 | -$12,354 | -1% | 147 | $2,600,000 | $2,600,505 | 3 | Summit Entertainment | - |
| 13 | 14 | +1 | The Blind Side | $1,270,000 | $1,257,186 | -$12,814 | -1% | 822 | $250,480,000 | $250,467,047 | 16 | Warner Bros. | - |
| 14 | 15 | +1 | The Last Station | $837,000 | $717,675 | -$119,325 | -14.3% | 354 | $4,647,000 | $4,527,796 | 8 | Sony Pictures Classics | - |
| 15 | 16 | +1 | Up in the Air | $610,000 | $607,465 | -$2,535 | -0.4% | 403 | $83,014,000 | $83,011,223 | 14 | Paramount Pictures | - |
| 16 | 22 | +6 | A Single Man | $455,000 | $376,387 | -$78,613 | -17.3% | 354 | $8,593,000 | $8,514,558 | 13 | The Weinstein Company | - |
| 17 | 20 | +3 | The Hurt Locker | $439,000 | - | - | - | 274 | $14,700,000 | - | 37 | Summit Entertainment | - |
| 18 | 23 | +5 | An Education | $409,000 | $365,603 | -$43,397 | -10.6% | 223 | $12,088,000 | $12,042,219 | 22 | Sony Pictures Classics | - |
| 19 | 28 | +9 | A Prophet | $265,000 | $222,524 | -$42,476 | -16% | 30 | $517,000 | $475,151 | 2 | Sony Pictures Classics | - |
| 20 | 27 | +7 | From Paris with Love | $230,000 | $267,682 | +$37,682 | +16.4% | 401 | $23,940,000 | $23,979,741 | 5 | Lionsgate | - |
| 21 | 31 | +10 | Precious | $200,000 | $181,674 | -$18,326 | -9.2% | 217 | $47,410,000 | $47,395,661 | 18 | Lionsgate | - |
| 22 | 30 | +8 | The Twilight Saga: New Moon | $194,000 | $188,045 | -$5,955 | -3.1% | 261 | $296,307,000 | $296,301,843 | 16 | Summit Entertainment | - |
| 23 | 33 | +10 | The Lovely Bones | $160,000 | $170,986 | +$10,986 | +6.9% | 263 | $43,808,000 | $43,818,839 | 13 | DreamWorks | - |
| 24 | 34 | +10 | The White Ribbon | $156,000 | $140,774 | -$15,226 | -9.8% | 106 | $1,726,000 | $1,710,787 | 10 | Sony Pictures Classics | - |
| 25 | 35 | +10 | The Young Victoria | $135,000 | $134,896 | -$104 | <0.1% | 134 | $10,422,000 | $10,422,449 | 12 | Apparition | - |
| 26 | 36 | +10 | My Name Is Khan | $127,000 | $129,122 | +$2,122 | +1.7% | 90 | $3,831,000 | $3,834,048 | 4 | Fox Searchlight Pictures | - |
| 27 | 46 | +19 | The Imaginarium of Doctor Parnassus | $43,900 | $37,848 | -$6,052 | -13.8% | 71 | $7,510,300 | $7,504,196 | 11 | Sony Pictures Classics | - |
| 28 | 45 | +17 | The Secret of Kells | $40,000 | $39,826 | -$174 | -0.4% | 1 | $40,000 | $39,826 | 1 | GKIDS | - |
| 29 | 49 | +20 | The Messenger | $33,000 | $32,118 | -$882 | -2.7% | 32 | $1,007,500 | $1,006,655 | 17 | Oscilloscope | - |
| 30 | 53 | +23 | Broken Embraces | $30,300 | $28,177 | -$2,123 | -7% | 40 | $4,651,700 | $4,649,582 | 16 | Sony Pictures Classics | - |
| 31 | 66 | +35 | Nine | $12,000 | $9,552 | -$2,448 | -20.4% | 46 | $19,666,400 | $19,664,001 | 12 | The Weinstein Company | - |
| 32 | 63 | +31 | Preacher's Kid | $9,400 | $9,936 | +$536 | +5.7% | 16 | $483,100 | $483,663 | 6 | 8x Entertainment | - |
| 33 | 69 | +36 | Youth in Revolt | $8,000 | $8,082 | +$82 | +1% | 12 | $15,219,000 | $15,219,126 | 9 | Dimension Films | - |
| 34 | 71 | +37 | The Road | $7,000 | $7,022 | +$22 | +0.3% | 22 | $8,104,500 | $8,104,518 | 15 | Dimension Films | - |
| 35 | 74 | +39 | Terribly Happy | $6,500 | $6,268 | -$232 | -3.6% | 6 | $90,500 | $90,260 | 5 | Oscilloscope | - |
