| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $78,004 | -17.4% | 9 | +1 | $8,667 | $206,118 | 2 | Walt Disney Pictures | false | false |
| 2 | - | The Hurt Locker | $18,011 | - | 4 | - | $4,502 | $59,635 | 6 | N/A | false | false |
| 3 | 2 | Avatar | $17,100 | -20.2% | 3 | -2 | $5,700 | $1,126,079 | 13 | 20th Century Fox International | false | false |
| 4 | 4 | The Widows of Thursdays | $12,688 | -23.5% | 7 | - | $1,812 | $34,503 | 2 | N/A | false | false |
| 5 | 3 | Edge of Darkness | $12,002 | -29.4% | 7 | - | $1,714 | $71,458 | 3 | Warner Bros. | false | false |
| 6 | - | Couples Retreat | $11,707 | - | 6 | - | $1,951 | $11,707 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 6 | The Blind Side | $10,854 | +12% | 4 | - | $2,713 | $27,577 | 2 | Warner Bros. | false | false |
| 8 | 5 | Did You Hear About the Morgans? | $9,597 | -24.4% | 5 | - | $1,919 | $58,845 | 3 | Sony Pictures Releasing | false | false |
| 9 | 7 | Nine | $5,954 | -37.6% | 3 | - | $1,984 | $18,253 | 2 | Sony Pictures Releasing | false | false |
| 10 | 8 | Tooth Fairy | $5,056 | -20.5% | 4 | - | $1,264 | $52,577 | 3 | 20th Century Fox International | false | false |
| 11 | 12 | A Serious Man | $2,762 | -18.3% | 1 | - | $2,762 | $16,501 | 3 | Universal Pictures International (UPI) | false | false |
| 12 | 14 | Precious | $2,633 | -5.3% | 3 | - | $877 | $44,762 | 5 | N/A | false | false |
| 13 | 9 | An Education | $2,472 | -57.1% | 2 | -2 | $1,236 | $51,402 | 4 | Sony Pictures Releasing | false | false |
| 14 | 13 | The Wolfman | $1,330 | -54.7% | 1 | -1 | $1,330 | $57,406 | 5 | Universal Pictures International (UPI) | false | false |
| 15 | - | One Day You'll Understand | $1,206 | - | 1 | - | $1,206 | $1,206 | 1 | N/A | true | false |
| 16 | 15 | The Girl with the Dragon Tattoo | $890 | -45.9% | 1 | - | $890 | $80,876 | 8 | N/A | false | false |
| 17 | 16 | Alvin and the Chipmunks: The Squeakquel | $884 | -23% | 2 | -1 | $442 | $168,047 | 11 | 20th Century Fox International | false | false |
| 18 | 18 | The Girl by the Lake 2009 Re-release | $597 | -30.4% | 1 | - | $597 | $3,764 | 3 | N/A | false | false |
| 19 | 10 | Invictus | $419 | -90.2% | 1 | -3 | $419 | $210,474 | 8 | Warner Bros. | false | false |
| 20 | 19 | Old Dogs | $59 | -91.8% | 1 | -2 | $59 | $137,112 | 8 | Walt Disney Pictures | false | false |
