| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $1,327,227 | -20.5% | 132 | +1 | $10,054 | $3,648,996 | 2 | Walt Disney Pictures | false | false |
| 2 | - | Shutter Island | $308,958 | - | 44 | - | $7,021 | $308,958 | 1 | Paramount Pictures International | true | false |
| 3 | 2 | Edge of Darkness | $132,429 | -37.2% | 65 | - | $2,037 | $802,173 | 3 | Warner Bros. | false | false |
| 4 | - | The Hurt Locker | $110,761 | - | 49 | - | $2,260 | $648,088 | 6 | Distribution Company | false | false |
| 5 | - | Did You Hear About the Morgans? | $85,684 | - | 30 | - | $2,856 | $85,684 | 1 | Sony Pictures Releasing | true | false |
| 6 | 3 | Avatar | $84,370 | -38.2% | 67 | -19 | $1,259 | $13,303,290 | 11 | 20th Century Fox International | false | false |
| 7 | - | Crazy Heart | $61,585 | - | 10 | - | $6,158 | $61,585 | 1 | 20th Century Fox International | true | false |
| 8 | 5 | The Wolfman | $45,186 | -35.1% | 62 | +1 | $728 | $1,055,103 | 5 | Universal Pictures International (UPI) | false | false |
| 9 | 24 | The Secret in Their Eyes | $39,445 | +686.5% | 61 | +45 | $646 | $9,247,153 | 31 | Distribution Company | false | false |
| 10 | 6 | Percy Jackson & the Olympians: The Lightning Thief | $37,407 | -43.8% | 57 | +1 | $656 | $672,662 | 4 | 20th Century Fox International | false | false |
| 11 | 18 | Precious | $30,216 | +225.7% | 25 | +10 | $1,208 | $238,231 | 5 | N/A | false | false |
| 12 | 10 | Invictus | $29,647 | -20.3% | 41 | -2 | $723 | $944,998 | 7 | Warner Bros. | false | false |
| 13 | 4 | Bad Lieutenant: Port of Call New Orleans | $27,092 | -65.2% | 33 | - | $820 | $128,584 | 2 | Distribution Company | false | false |
| 14 | 8 | The Imaginarium of Doctor Parnassus | $26,746 | -40.4% | 27 | - | $990 | $211,277 | 3 | Sony Pictures Releasing | false | false |
| 15 | 7 | Couples Retreat | $24,770 | -57.8% | 23 | - | $1,076 | $100,996 | 2 | Universal Pictures International (UPI) | false | false |
| 16 | 9 | Valentine's Day | $16,374 | -56% | 31 | -29 | $528 | $860,095 | 5 | Warner Bros. | false | false |
| 17 | 12 | Old Dogs | $11,309 | -54.3% | 40 | -22 | $282 | $1,496,959 | 8 | Walt Disney Pictures | false | false |
| 18 | 13 | The Girl with the Dragon Tattoo | $8,942 | -62.7% | 17 | -6 | $526 | $219,150 | 4 | N/A | false | false |
| 19 | 11 | A Serious Man | $8,652 | -70.1% | 7 | -7 | $1,236 | $116,628 | 3 | Universal Pictures International (UPI) | false | false |
| 20 | 36 | Astro Boy | $7,372 | +1,552.9% | 16 | +11 | $460 | $162,181 | 7 | Alfa Films | false | false |
| 21 | 17 | Our Beloved Month of August | $7,100 | -28.1% | 4 | - | $1,775 | $21,216 | 2 | N/A | false | false |
| 22 | 14 | Birds of Paradise | $5,447 | -62.7% | 19 | -14 | $286 | $183,866 | 4 | Sony Pictures Releasing | false | false |
| 23 | 20 | Alvin and the Chipmunks: The Squeakquel | $4,915 | -29.4% | 14 | -6 | $351 | $1,087,916 | 8 | 20th Century Fox International | false | false |
| 24 | 15 | Sherlock Holmes | $4,163 | -70% | 16 | -7 | $260 | $2,698,853 | 9 | Warner Bros. | false | false |
| 25 | - | Mongol: The Rise of Genghis Khan | $3,838 | - | 4 | - | $959 | $3,838 | 1 | Alfa Films | true | false |
| 26 | 19 | The Lovely Bones | $3,350 | -60.3% | 10 | -8 | $335 | $204,089 | 4 | Paramount Pictures International | false | false |
| 27 | 27 | Up in the Air | $2,900 | -8.8% | 12 | - | $241 | $722,103 | 8 | Paramount Pictures International | false | false |
| 28 | 43 | Inglourious Basterds | $2,859 | +3,565.4% | 2 | +1 | $1,429 | $1,221,949 | 28 | Universal Pictures International (UPI) | false | false |
| 29 | 16 | Tooth Fairy | $2,428 | -76.2% | 11 | -24 | $220 | $481,755 | 6 | 20th Century Fox International | false | false |
| 30 | 23 | Daybreakers | $2,130 | -58.6% | 4 | -5 | $532 | $386,438 | 8 | Distribution Company | false | false |
| 31 | 29 | The Princess and the Frog | $1,921 | -12% | 7 | -10 | $274 | $1,924,746 | 10 | Walt Disney Pictures | false | false |
| 32 | 22 | It's Complicated | $1,919 | -69.5% | 3 | -15 | $639 | $1,310,240 | 10 | Universal Pictures International (UPI) | false | false |
| 33 | 32 | Nine | $1,701 | +132.7% | 4 | - | $425 | $263,353 | 7 | Sony Pictures Releasing | false | false |
| 34 | 25 | The Wedding Song | $1,660 | -64% | 3 | -3 | $553 | $33,470 | 4 | Primer Plano Film Group | false | false |
| 35 | 21 | An Education | $1,595 | -76% | 4 | -3 | $398 | $183,065 | 6 | Sony Pictures Releasing | false | false |
| 36 | 28 | Nora's Will | $914 | -65% | 2 | -2 | $457 | $52,938 | 7 | Primer Plano Film Group | false | false |
| 37 | 26 | Easy Virtue | $880 | -79.5% | 2 | -1 | $440 | $106,464 | 9 | Sony Pictures Releasing | false | false |
| 38 | 30 | Zombieland | $854 | -57.5% | 1 | -3 | $854 | $103,265 | 7 | Sony Pictures Releasing | false | false |
| 39 | 37 | 2012 | $564 | +33.3% | 1 | - | $564 | $4,040,705 | 15 | Sony Pictures Releasing | false | false |
| 40 | 35 | The Young Victoria | $487 | -4.3% | 2 | -1 | $243 | $179,283 | 9 | Distribution Company | false | false |
| 41 | 44 | Ninja Assassin | $353 | +426.9% | 2 | +1 | $176 | $130,325 | 10 | Warner Bros. | false | false |
| 42 | 34 | The Wind Journeys | $259 | -55.2% | 2 | -1 | $129 | $5,374 | 5 | Primer Plano Film Group | false | false |
| 43 | 31 | Andres Doesn't Want to Take a Nap | $252 | -80.7% | 3 | -2 | $84 | $14,147 | 6 | Primer Plano Film Group | false | false |
| 44 | 39 | Let it Rain | $192 | -21.3% | 1 | - | $192 | $140,016 | 14 | Alfa Films | false | false |
| 45 | 33 | Law Abiding Citizen | $131 | -79.1% | 2 | -4 | $65 | $179,980 | 5 | Alfa Films | false | false |
| 46 | 40 | Broken Embraces | $130 | -19.3% | 1 | - | $130 | $518,310 | 24 | Universal Pictures International (UPI) | false | false |
