| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Shutter Island | $22,200,000 | $22,665,205 | +$465,205 | +2.1% | 3,003 | $75,076,000 | $75,541,271 | 2 | Paramount Pictures | - |
| 2 | 2 | - | Cop Out | $18,565,000 | $18,211,126 | -$353,874 | -1.9% | 3,150 | $18,565,000 | $18,211,126 | 1 | Warner Bros. | - |
| 3 | 3 | - | The Crazies | $16,521,000 | $16,067,552 | -$453,448 | -2.7% | 2,476 | $16,521,000 | $16,067,552 | 1 | Overture Films | - |
| 4 | 4 | - | Avatar | $14,000,000 | $13,655,274 | -$344,726 | -2.5% | 2,456 | $706,904,000 | $706,560,068 | 11 | Twentieth Century Fox | - |
| 5 | 5 | - | Percy Jackson & the Olympians: The Lightning Thief | $9,800,000 | $9,583,421 | -$216,579 | -2.2% | 3,302 | $71,214,000 | $70,998,280 | 3 | Twentieth Century Fox | - |
| 6 | 6 | - | Valentine's Day | $9,505,000 | $9,063,036 | -$441,964 | -4.6% | 3,578 | $100,358,000 | $99,916,240 | 3 | Warner Bros. | - |
| 7 | 7 | - | Dear John | $5,000,000 | $4,808,498 | -$191,502 | -3.8% | 3,006 | $72,624,000 | $72,432,096 | 4 | Screen Gems | - |
| 8 | 8 | - | The Wolfman | $4,123,000 | $4,259,865 | +$136,865 | +3.3% | 3,043 | $57,244,000 | $57,380,125 | 3 | Universal Pictures | - |
| 9 | 9 | - | Tooth Fairy | $3,450,000 | $3,425,333 | -$24,667 | -0.7% | 2,249 | $53,866,000 | $53,841,454 | 6 | Twentieth Century Fox | - |
| 10 | 10 | - | Crazy Heart | $2,540,000 | $2,462,384 | -$77,616 | -3.1% | 1,148 | $25,087,000 | $25,009,496 | 11 | Fox Searchlight Pictures | - |
| 11 | 11 | - | The Blind Side | $1,295,000 | $1,238,477 | -$56,523 | -4.4% | 945 | $248,813,000 | $248,755,981 | 15 | Warner Bros. | - |
| 12 | 12 | - | The Book of Eli | $1,130,000 | $1,112,493 | -$17,507 | -1.5% | 975 | $92,524,000 | $92,506,955 | 7 | Warner Bros. | - |
| 13 | 16 | +3 | The Last Station | $1,061,000 | $970,048 | -$90,952 | -8.6% | 352 | $3,432,000 | $3,340,876 | 7 | Sony Pictures Classics | - |
| 14 | 14 | - | Edge of Darkness | $1,040,000 | $1,017,209 | -$22,791 | -2.2% | 1,255 | $42,193,000 | $42,170,286 | 5 | Warner Bros. | - |
| 15 | 13 | -2 | From Paris with Love | $1,030,000 | $1,055,240 | +$25,240 | +2.5% | 1,278 | $23,300,000 | $23,324,666 | 4 | Lionsgate | - |
| 16 | 15 | -1 | When in Rome | $1,015,000 | $1,003,452 | -$11,548 | -1.1% | 930 | $30,873,000 | $30,861,655 | 5 | Walt Disney Studios Motion Pictures | - |
| 17 | 18 | +1 | The Ghost Writer | $870,000 | $789,064 | -$80,936 | -9.3% | 43 | $1,129,000 | $1,048,233 | 2 | Summit Entertainment | - |
| 18 | 17 | -1 | Up in the Air | $835,000 | $802,081 | -$32,919 | -3.9% | 586 | $82,112,000 | $82,078,918 | 13 | Paramount Pictures | - |
| 19 | 19 | - | Alvin and the Chipmunks: The Squeakquel | $800,000 | $771,365 | -$28,635 | -3.6% | 707 | $216,585,000 | $216,556,981 | 10 | Twentieth Century Fox | - |
| 20 | 21 | +1 | It's Complicated | $529,000 | $512,825 | -$16,175 | -3.1% | 462 | $111,529,000 | $111,512,760 | 10 | Universal Pictures | - |
| 21 | 23 | +2 | An Education | $353,000 | $320,428 | -$32,572 | -9.2% | 209 | $11,550,000 | $11,517,495 | 21 | Sony Pictures Classics | - |
| 22 | 25 | +3 | The Twilight Saga: New Moon | $300,000 | $289,048 | -$10,952 | -3.7% | 298 | $296,023,000 | $296,012,199 | 15 | Summit Entertainment | - |
| 23 | 24 | +1 | A Single Man | $296,000 | $298,347 | +$2,347 | +0.8% | 242 | $7,954,000 | $7,956,032 | 12 | The Weinstein Company | - |
| 24 | 26 | +2 | My Name Is Khan | $254,000 | $254,221 | +$221 | <0.1% | 119 | $3,634,000 | $3,634,423 | 3 | Fox Searchlight Pictures | - |
| 25 | 28 | +3 | The Young Victoria | $220,000 | $213,873 | -$6,127 | -2.8% | 187 | $10,183,000 | $10,176,454 | 11 | Apparition | - |
| 26 | 32 | +6 | The Spy Next Door | $200,000 | $196,710 | -$3,290 | -1.6% | 195 | $24,270,000 | $24,268,808 | 7 | Lionsgate | - |
| 27 | 30 | +3 | Precious | $170,000 | $204,887 | +$34,887 | +20.5% | 268 | $47,070,000 | $47,109,625 | 17 | Lionsgate | - |
| 28 | 34 | +6 | A Prophet | $170,000 | $163,773 | -$6,227 | -3.7% | 9 | $170,000 | $163,773 | 1 | Sony Pictures Classics | - |
| 29 | 36 | +7 | The White Ribbon | $168,000 | $157,474 | -$10,526 | -6.3% | 82 | $1,501,000 | $1,490,471 | 9 | Sony Pictures Classics | - |
| 30 | 37 | +7 | The Lovely Bones | $146,000 | $150,318 | +$4,318 | +3% | 261 | $43,588,000 | $43,592,366 | 12 | DreamWorks | - |
| 31 | 41 | +10 | The Imaginarium of Doctor Parnassus | $89,000 | $86,194 | -$2,806 | -3.2% | 96 | $7,429,100 | $7,426,313 | 10 | Sony Pictures Classics | - |
| 32 | 42 | +10 | Formosa Betrayed | $69,000 | $77,326 | +$8,326 | +12.1% | 15 | $69,000 | $77,326 | 1 | Screen Media Films | - |
| 33 | 44 | +11 | Leap Year | $67,000 | $65,095 | -$1,905 | -2.8% | 124 | $25,895,000 | $25,893,485 | 8 | Universal Pictures | - |
| 34 | 48 | +14 | Nine | $40,500 | $42,252 | +$1,752 | +4.3% | 125 | $19,626,500 | $19,628,645 | 11 | The Weinstein Company | - |
| 35 | 52 | +17 | Broken Embraces | $38,500 | $37,808 | -$692 | -1.8% | 38 | $4,602,700 | $4,602,057 | 15 | Sony Pictures Classics | - |
| 36 | 55 | +19 | The Road | $28,500 | $28,664 | +$164 | +0.6% | 74 | $8,082,500 | $8,082,704 | 14 | Dimension Films | - |
| 37 | 57 | +20 | Preacher's Kid | $25,800 | $27,798 | +$1,998 | +7.7% | 41 | $463,900 | $465,896 | 5 | 8x Entertainment | - |
| 38 | 62 | +24 | Defendor | $21,000 | $18,628 | -$2,372 | -11.3% | 4 | $40,010 | $37,606 | 2 | Darius Films | - |
| 39 | 64 | +25 | Youth in Revolt | $14,000 | $13,439 | -$561 | -4% | 23 | $15,205,000 | $15,204,039 | 8 | Dimension Films | - |
| 40 | 65 | +25 | Creation | $11,100 | $12,266 | +$1,166 | +10.5% | 6 | $235,100 | $236,293 | 6 | Newmarket Films | - |
| 41 | 68 | +27 | Bad Lieutenant: Port of Call New Orleans | $10,000 | $9,491 | -$509 | -5.1% | 13 | $1,698,510 | $1,697,956 | 15 | First Look International | - |
| 42 | 76 | +34 | Saint John of Las Vegas | $5,000 | $5,016 | +$16 | +0.3% | 5 | $100,600 | $100,669 | 5 | IndieVest Pictures | - |
