| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Alice in Wonderland | $94,424 | - | 8 | - | $11,803 | $94,424 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Avatar | $21,427 | -35.2% | 5 | -2 | $4,285 | $1,099,379 | 12 | 20th Century Fox International | false | false |
| 3 | 2 | Edge of Darkness | $17,000 | -30.2% | 7 | - | $2,428 | $52,345 | 2 | Warner Bros. | false | false |
| 4 | - | The Widows of Thursdays | $16,581 | - | 7 | - | $2,368 | $16,581 | 1 | N/A | true | false |
| 5 | 3 | Did You Hear About the Morgans? | $12,701 | -37.8% | 5 | - | $2,540 | $43,514 | 2 | Sony Pictures Releasing | false | false |
| 6 | - | The Blind Side | $9,695 | - | 4 | - | $2,423 | $9,695 | 1 | Warner Bros. | true | false |
| 7 | - | Nine | $9,537 | - | 3 | - | $3,179 | $9,537 | 1 | Sony Pictures Releasing | true | false |
| 8 | 4 | Tooth Fairy | $6,360 | -50.9% | 4 | -1 | $1,590 | $46,411 | 2 | 20th Century Fox International | false | false |
| 9 | 6 | An Education | $5,760 | -40.8% | 4 | - | $1,440 | $46,110 | 3 | Sony Pictures Releasing | false | false |
| 10 | 8 | Invictus | $4,267 | -47.5% | 4 | -3 | $1,066 | $206,536 | 7 | Warner Bros. | false | false |
| 11 | 7 | Valentine's Day | $3,585 | -56% | 3 | -3 | $1,195 | $134,009 | 4 | Warner Bros. | false | false |
| 12 | 14 | A Serious Man | $3,382 | +6.7% | 1 | - | $3,382 | $12,795 | 2 | Universal Pictures International (UPI) | false | false |
| 13 | 9 | The Wolfman | $2,934 | -53.8% | 2 | -3 | $1,467 | $55,506 | 4 | Universal Pictures International (UPI) | false | false |
| 14 | 10 | Precious | $2,781 | -37.8% | 3 | -1 | $927 | $39,615 | 4 | N/A | false | false |
| 15 | 11 | The Girl with the Dragon Tattoo | $1,645 | -59.7% | 1 | -3 | $1,645 | $79,512 | 7 | N/A | false | false |
| 16 | 18 | Alvin and the Chipmunks: The Squeakquel | $1,148 | -14% | 3 | - | $382 | $167,092 | 10 | 20th Century Fox International | false | false |
| 17 | 16 | Sherlock Holmes | $1,063 | -58.2% | 1 | -3 | $1,063 | $200,256 | 8 | Warner Bros. | false | false |
| 18 | 19 | The Girl by the Lake 2009 Re-release | $858 | -31.2% | 1 | - | $858 | $2,587 | 2 | N/A | false | false |
| 19 | 12 | Old Dogs | $722 | -79% | 3 | -1 | $240 | $136,919 | 7 | Walt Disney Pictures | false | false |
| 20 | 15 | Percy Jackson & the Olympians: The Lightning Thief | $460 | -82.8% | 1 | -3 | $460 | $45,739 | 4 | 20th Century Fox International | false | false |
| 21 | 20 | Easy Virtue | $422 | -57.3% | 1 | -1 | $422 | $31,895 | 6 | Sony Pictures Releasing | false | false |
| 22 | 21 | The Princess and the Frog | $212 | -72.5% | 1 | - | $212 | $80,731 | 9 | Walt Disney Pictures | false | false |
| 23 | 24 | Astro Boy | $202 | -2.9% | 2 | -1 | $101 | $30,546 | 6 | N/A | false | false |
| 24 | 17 | Up in the Air | $142 | -91.4% | 4 | - | $35 | $135,536 | 7 | Paramount Pictures International | false | false |
