| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Alice in Wonderland | $1,039,374 | - | 93 | - | $11,176 | $1,039,374 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Miss You Like Crazy | $613,987 | -59.2% | 85 | - | $7,223 | $2,547,978 | 2 | Star Cinema | false | false |
| 3 | - | Cop Out | $137,772 | - | 50 | - | $2,755 | $137,772 | 1 | Warner Bros. | true | false |
| 4 | 2 | Percy Jackson & the Olympians: The Lightning Thief | $77,425 | -67.5% | 51 | -20 | $1,518 | $1,910,823 | 4 | 20th Century Fox International | false | false |
| 5 | - | Up in the Air | $46,343 | - | 12 | - | $3,861 | $46,343 | 1 | United International Pictures | true | false |
| 6 | - | The Fourth Kind | $43,652 | - | 20 | - | $2,182 | $43,652 | 1 | Viva International Pictures | true | false |
| 7 | - | The Road | $40,811 | - | 16 | - | $2,550 | $40,811 | 1 | Pioneer Films | true | false |
| 8 | 3 | From Paris with Love | $38,382 | -61.6% | 30 | - | $1,279 | $157,758 | 2 | Viva International Pictures | false | false |
| 9 | 4 | The Wolfman | $20,070 | -73.5% | 34 | -18 | $590 | $548,388 | 4 | United International Pictures | false | false |
| 10 | 8 | Avatar | $18,543 | -43.6% | 5 | -2 | $3,708 | $5,855,209 | 12 | 20th Century Fox International | false | false |
| 11 | 7 | Valentine's Day | $7,983 | -82.4% | 14 | -28 | $570 | $723,093 | 4 | Warner Bros. | false | false |
| 12 | 5 | Armored | $6,070 | -91.5% | 23 | -27 | $263 | $97,332 | 2 | Sony Pictures Releasing | false | false |
| 13 | 6 | It's Complicated | $4,876 | -92.8% | 8 | -8 | $609 | $74,972 | 2 | United International Pictures | false | false |
| 14 | 9 | Infestation | $4,749 | -82.3% | 15 | -2 | $316 | $36,756 | 2 | Pioneer Films | false | false |
| 15 | 13 | Cloudy with a Chance of Meatballs | $3,248 | -29.8% | 2 | - | $1,624 | $258,306 | 6 | Sony Pictures Releasing | false | false |
| 16 | - | Crazy Heart | $2,180 | - | 1 | - | $2,180 | $2,180 | 1 | 20th Century Fox International | true | false |
| 17 | 12 | Dear John | $1,648 | -88.3% | 10 | -8 | $164 | $455,383 | 5 | Pioneer Films | false | false |
| 18 | 16 | Legion | $1,534 | -11.4% | 2 | -2 | $767 | $1,136,978 | 7 | Sony Pictures Releasing | false | false |
| 19 | 11 | Cirque du Freak: The Vampire's Assistant | $1,389 | -90.6% | 2 | -11 | $694 | $253,622 | 6 | United International Pictures | false | false |
| 20 | 18 | Invictus | $1,150 | -9.4% | 5 | - | $230 | $56,523 | 3 | Warner Bros. | false | false |
| 21 | 19 | Case 39 | $610 | -33.3% | 1 | -2 | $610 | $64,354 | 5 | United International Pictures | false | false |
| 22 | 17 | Messengers 2: The Scarecrow | $564 | -61.3% | 2 | -1 | $282 | $131,497 | 5 | Viva International Pictures | false | false |
| 23 | 20 | Couples Retreat | $309 | -65% | 2 | -2 | $154 | $12,318 | 3 | United International Pictures | false | false |
| 24 | 15 | The Princess and the Frog | $250 | -86.8% | 1 | -3 | $250 | $284,188 | 5 | Walt Disney Pictures | false | false |
| 25 | 21 | Tooth Fairy | $176 | -40.3% | 2 | +1 | $88 | $472,939 | 7 | 20th Century Fox International | false | false |
