| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Shutter Island | $40,200,000 | $41,062,440 | +$862,440 | +2.1% | 2,991 | $40,200,000 | $41,062,440 | 1 | Paramount Pictures | - |
| 2 | 2 | - | Valentine's Day | $17,160,000 | $16,665,299 | -$494,701 | -2.9% | 3,665 | $87,422,000 | $86,927,385 | 2 | Warner Bros. | - |
| 3 | 3 | - | Avatar | $16,100,000 | $16,240,857 | +$140,857 | +0.9% | 2,581 | $687,821,000 | $687,962,011 | 10 | Twentieth Century Fox | - |
| 4 | 4 | - | Percy Jackson & the Olympians: The Lightning Thief | $15,300,000 | $15,254,421 | -$45,579 | -0.3% | 3,396 | $58,760,000 | $58,714,813 | 2 | Twentieth Century Fox | - |
| 5 | 5 | - | The Wolfman | $9,846,000 | $9,895,105 | +$49,105 | +0.5% | 3,223 | $50,315,000 | $50,363,730 | 2 | Universal Pictures | - |
| 6 | 6 | - | Dear John | $7,300,000 | $7,130,552 | -$169,448 | -2.3% | 3,062 | $65,971,000 | $65,801,765 | 3 | Screen Gems | - |
| 7 | 7 | - | Tooth Fairy | $4,500,000 | $4,354,280 | -$145,720 | -3.2% | 2,523 | $49,867,000 | $49,721,400 | 5 | Twentieth Century Fox | - |
| 8 | 8 | - | Crazy Heart | $3,025,000 | $2,964,586 | -$60,414 | -2% | 1,089 | $21,585,000 | $21,524,784 | 10 | Fox Searchlight Pictures | - |
| 9 | 9 | - | From Paris with Love | $2,500,000 | $2,661,829 | +$161,829 | +6.5% | 2,311 | $21,200,000 | $21,361,504 | 3 | Lionsgate | - |
| 10 | 10 | - | Edge of Darkness | $2,210,000 | $2,243,311 | +$33,311 | +1.5% | 2,118 | $40,314,000 | $40,347,222 | 4 | Warner Bros. | - |
| 11 | 11 | - | The Book of Eli | $1,845,000 | $1,888,305 | +$43,305 | +2.3% | 1,455 | $90,732,000 | $90,775,391 | 6 | Warner Bros. | - |
| 12 | 12 | - | When in Rome | $1,747,000 | $1,737,917 | -$9,083 | -0.5% | 1,627 | $29,354,000 | $29,344,987 | 4 | Walt Disney Studios Motion Pictures | - |
| 13 | 13 | - | The Blind Side | $1,500,000 | $1,451,100 | -$48,900 | -3.3% | 1,060 | $24,712,000 | $247,071,052 | 14 | Warner Bros. | - |
| 14 | 14 | - | Up in the Air | $1,073,000 | $1,052,036 | -$20,964 | -2% | 727 | $80,930,000 | $80,908,880 | 12 | Paramount Pictures | - |
| 15 | 15 | - | Alvin and the Chipmunks: The Squeakquel | $935,000 | $935,085 | +$85 | <0.1% | 841 | $215,581,000 | $215,581,073 | 9 | Twentieth Century Fox | - |
| 16 | 16 | - | Sherlock Holmes | $880,000 | $846,490 | -$33,510 | -3.8% | 713 | $205,568,000 | $205,534,198 | 9 | Warner Bros. | - |
| 17 | 17 | - | My Name Is Khan | $720,000 | $700,885 | -$19,115 | -2.7% | 125 | $3,272,000 | $3,253,168 | 2 | Fox Searchlight Pictures | - |
| 18 | 18 | - | It's Complicated | $706,000 | $699,510 | -$6,490 | -0.9% | 598 | $110,731,000 | $110,724,780 | 9 | Universal Pictures | - |
| 19 | 19 | - | Legion | $630,000 | $625,408 | -$4,592 | -0.7% | 786 | $39,226,000 | $39,221,554 | 5 | Screen Gems | - |
| 20 | 20 | - | The Last Station | $601,000 | $558,214 | -$42,786 | -7.1% | 109 | $2,205,000 | $2,162,370 | 6 | Sony Pictures Classics | - |
| 21 | 21 | - | The Princess and the Frog | $519,000 | $539,685 | +$20,685 | +4% | 405 | $102,653,000 | $102,673,293 | 13 | Walt Disney Studios Motion Pictures | - |
| 22 | 22 | - | The Twilight Saga: New Moon | $385,000 | $382,460 | -$2,540 | -0.7% | 325 | $295,601,000 | $295,598,642 | 14 | Summit Entertainment | - |
| 23 | 23 | - | An Education | $378,000 | $354,481 | -$23,519 | -6.2% | 241 | $11,082,000 | $11,058,964 | 20 | Sony Pictures Classics | - |
| 24 | 24 | - | A Single Man | $347,000 | $340,101 | -$6,899 | -2% | 255 | $7,514,000 | $7,506,512 | 11 | The Weinstein Company | - |
| 25 | 26 | +1 | The Lovely Bones | $276,000 | $266,297 | -$9,703 | -3.5% | 469 | $43,374,000 | $43,364,519 | 11 | DreamWorks | - |
| 26 | 28 | +2 | The Young Victoria | $244,000 | $248,564 | +$4,564 | +1.9% | 219 | $9,837,000 | $9,841,072 | 10 | Apparition | - |
| 27 | 27 | - | The Spy Next Door | $230,000 | $257,421 | +$27,421 | +11.9% | 215 | $24,000,000 | $24,026,111 | 6 | Lionsgate | - |
| 28 | 29 | +1 | The Ghost Writer | $179,000 | $183,009 | +$4,009 | +2.2% | 4 | $179,000 | $183,009 | 1 | Summit Entertainment | - |
| 29 | 30 | +1 | The White Ribbon | $171,000 | $177,780 | +$6,780 | +4% | 72 | $1,267,000 | $1,273,179 | 8 | Sony Pictures Classics | - |
| 30 | 32 | +2 | Precious | $170,000 | $160,848 | -$9,152 | -5.4% | 259 | $46,830,000 | $46,819,335 | 16 | Lionsgate | - |
| 31 | 33 | +2 | The Imaginarium of Doctor Parnassus | $156,000 | $143,775 | -$12,225 | -7.8% | 191 | $7,277,000 | $7,264,776 | 9 | Sony Pictures Classics | - |
| 32 | 35 | +3 | Leap Year | $114,000 | $108,535 | -$5,465 | -4.8% | 187 | $25,795,000 | $25,789,265 | 7 | Universal Pictures | - |
| 33 | 43 | +10 | Preacher's Kid | $60,200 | $53,712 | -$6,488 | -10.8% | 72 | $428,700 | $422,186 | 4 | 8x Entertainment | - |
| 34 | 40 | +6 | Broken Embraces | $58,700 | $59,486 | +$786 | +1.3% | 53 | $4,531,300 | $4,532,060 | 14 | Sony Pictures Classics | - |
| 35 | 42 | +7 | The Road | $51,000 | $56,448 | +$5,448 | +10.7% | 111 | $8,019,000 | $8,025,059 | 13 | Dimension Films | - |
| 36 | 51 | +15 | Creation | $30,300 | $29,753 | -$547 | -1.8% | 10 | $215,700 | $215,151 | 5 | Newmarket Films | - |
| 37 | 52 | +15 | The Messenger | $25,200 | $25,972 | +$772 | +3.1% | 28 | $892,600 | $893,323 | 15 | Oscilloscope | - |
| 38 | 53 | +15 | Youth in Revolt | $21,000 | $21,213 | +$213 | +1% | 32 | $15,180,000 | $15,180,449 | 7 | Dimension Films | - |
| 39 | 54 | +15 | Nine | $19,000 | $21,193 | +$2,193 | +11.5% | 50 | $19,572,000 | $19,574,921 | 10 | The Weinstein Company | - |
| 40 | 59 | +19 | Terribly Happy | $15,200 | $14,148 | -$1,052 | -6.9% | 6 | $66,700 | $65,625 | 3 | Oscilloscope | - |
| 41 | 64 | +23 | Saint John of Las Vegas | $12,200 | $11,891 | -$309 | -2.5% | 8 | $90,500 | $90,213 | 4 | IndieVest Pictures | - |
| 42 | 71 | +29 | Bad Lieutenant: Port of Call New Orleans | $5,006 | $4,479 | -$527 | -10.5% | 10 | $1,685,900 | $1,685,405 | 14 | First Look International | - |
