| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $1,004,329 | +4% | 103 | -5 | $9,750 | $23,039,524 | 11 | 20th Century Fox International | false | false |
| 2 | 5 | Cloudy with a Chance of Meatballs | $749,577 | +88.2% | 83 | +3 | $9,031 | $1,853,160 | 2 | Sony Pictures Releasing | false | false |
| 3 | 6 | The Princess and the Frog | $533,696 | +40.7% | 122 | -3 | $4,374 | $2,628,451 | 4 | Walt Disney Pictures | false | false |
| 4 | 8 | Eep! 2010 Re-release | $504,762 | +107.2% | 87 | - | $5,801 | $1,166,172 | 2 | Independent Films | false | false |
| 5 | 3 | Shutter Island | $440,781 | -0.4% | 51 | +1 | $8,642 | $1,087,452 | 2 | Universal Pictures International (UPI) | false | false |
| 6 | 2 | Valentine's Day | $438,409 | -28.6% | 106 | - | $4,135 | $2,855,546 | 3 | Warner Bros. | false | false |
| 7 | 4 | Percy Jackson & the Olympians: The Lightning Thief | $363,653 | -9.5% | 96 | - | $3,788 | $1,628,793 | 3 | Warner Bros. | false | false |
| 8 | 7 | Gangsterboys | $327,646 | -1.5% | 39 | - | $8,401 | $902,340 | 2 | Independent Films | false | false |
| 9 | - | The Lovely Bones | $319,188 | - | 54 | - | $5,910 | $326,107 | 1 | Universal Pictures International (UPI) | true | false |
| 10 | 10 | Alvin and the Chipmunks: The Squeakquel | $265,947 | +73.3% | 106 | -1 | $2,508 | $6,952,592 | 10 | Warner Bros. | false | false |
| 11 | 9 | The Wolfman | $111,454 | -28.4% | 56 | +7 | $1,990 | $638,309 | 3 | Universal Pictures International (UPI) | false | false |
| 12 | 15 | The Spy Next Door 2010 Re-release | $110,213 | +49.3% | 44 | - | $2,504 | $531,321 | 4 | A-Film Distribution | false | false |
| 13 | 12 | A Single Man | $86,054 | +3.9% | 20 | - | $4,302 | $503,320 | 4 | Cinéart | false | false |
| 14 | 11 | Edge of Darkness | $70,984 | -30.9% | 55 | -10 | $1,290 | $1,104,664 | 5 | Entertainment One | false | false |
| 15 | 16 | Love Life | $66,318 | -6.2% | 67 | -6 | $989 | $12,468,441 | 14 | Benelux Film Distributors | false | false |
| 16 | - | Anubis en de wraak van Arghus | $59,368 | - | 41 | - | $1,448 | $3,779,210 | 11 | Independent Films | false | false |
| 17 | 17 | The Girl Who Played with Fire | $56,038 | -17.7% | 35 | +1 | $1,601 | $961,377 | 6 | Benelux Film Distributors | false | false |
| 18 | 13 | Sherlock Holmes | $54,153 | -32.1% | 43 | -14 | $1,259 | $3,994,559 | 8 | Warner Bros. | false | false |
| 19 | 18 | A Prophet | $51,650 | -13.2% | 25 | - | $2,066 | $352,101 | 4 | Cinemien | false | false |
| 20 | - | Daybreakers | $50,063 | - | 16 | - | $3,128 | $79,304 | 1 | Benelux Film Distributors | true | false |
