| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $45,587 | -20% | 21 | - | $2,170 | $1,533,691 | 11 | 20th Century Fox International | false | false |
| 2 | 2 | The Wolfman | $27,732 | -44.1% | 9 | - | $3,081 | $94,027 | 2 | United International Pictures | false | false |
| 3 | - | Edge of Darkness | $21,324 | - | 5 | - | $4,264 | $21,324 | 1 | N/A | true | false |
| 4 | 3 | Dear John | $19,532 | -38.9% | 6 | - | $3,255 | $62,705 | 2 | N/A | false | false |
| 5 | - | The Lovely Bones | $17,945 | - | 7 | - | $2,563 | $17,945 | 1 | United International Pictures | true | false |
| 6 | - | The Spy Next Door 2010 Re-release | $17,945 | - | 5 | - | $3,589 | $17,945 | 1 | N/A | true | false |
| 7 | 6 | Cloudy with a Chance of Meatballs | $14,932 | -24.9% | 16 | - | $933 | $101,531 | 4 | Sony Pictures Releasing | false | false |
| 8 | 4 | Valentine's Day | $14,172 | -53.9% | 10 | - | $1,417 | $140,793 | 3 | Warner Bros. | false | false |
| 9 | 8 | It's Complicated | $13,478 | -22.4% | 7 | - | $1,925 | $162,968 | 5 | United International Pictures | false | false |
| 10 | 5 | Alvin and the Chipmunks: The Squeakquel | $11,370 | -45% | 8 | - | $1,421 | $59,069 | 3 | 20th Century Fox International | false | false |
| 11 | 7 | Up in the Air | $10,949 | -39.1% | 7 | - | $1,564 | $119,794 | 4 | United International Pictures | false | false |
| 12 | 10 | The Princess and the Frog | $7,851 | -30% | 10 | - | $785 | $158,092 | 6 | Walt Disney Pictures | false | false |
| 13 | 9 | The Book of Eli | $5,807 | -50.8% | 7 | - | $829 | $219,043 | 6 | N/A | false | false |
| 14 | 13 | An Education | $2,469 | -19.9% | 4 | - | $617 | $45,713 | 6 | N/A | false | false |
| 15 | 16 | Moon | $1,342 | +16.9% | 2 | - | $671 | $18,476 | 5 | N/A | false | false |
| 16 | 11 | Did You Hear About the Morgans? | $1,330 | -62.8% | 8 | - | $166 | $129,047 | 7 | Sony Pictures Releasing | false | false |
| 17 | 14 | Hachi: A Dog's Tale | $868 | -58.5% | 1 | - | $868 | $3,606 | 2 | N/A | false | false |
| 18 | 12 | Paranormal Activity | $694 | -78.5% | 5 | - | $138 | $70,475 | 5 | N/A | false | false |
| 19 | 15 | Everybody's Fine | $653 | -66% | 1 | - | $653 | $7,795 | 3 | Walt Disney Pictures | false | false |
