| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Avatar | $4,360,020 | -16.3% | 391 | -11 | $11,150 | $128,873,989 | 10 | 20th Century Fox International | false | false |
| 2 | 4 | The Princess and the Frog | $2,670,669 | +13% | 503 | +2 | $5,309 | $13,733,684 | 2 | Walt Disney Pictures | false | false |
| 3 | - | The Lovely Bones | $2,534,560 | - | 420 | - | $6,034 | $2,534,560 | 1 | Paramount Pictures International | true | false |
| 4 | 1 | Valentine's Day | $2,450,305 | -58.2% | 436 | +4 | $5,619 | $12,037,075 | 2 | Warner Bros. | false | false |
| 5 | 5 | Percy Jackson & the Olympians: The Lightning Thief | $2,302,192 | -2.5% | 457 | +3 | $5,037 | $8,087,132 | 2 | 20th Century Fox International | false | false |
| 6 | 3 | The Wolfman | $1,199,334 | -67.8% | 411 | +7 | $2,918 | $6,457,016 | 2 | Universal Pictures International (UPI) | false | false |
| 7 | - | Solomon Kane | $947,045 | - | 259 | - | $3,656 | $947,045 | 1 | Universal Pictures International (UPI) | true | false |
| 8 | 9 | Alvin and the Chipmunks: The Squeakquel | $941,269 | +41.1% | 397 | -31 | $2,370 | $35,853,365 | 9 | 20th Century Fox International | false | false |
| 9 | 7 | Invictus | $883,456 | -27.7% | 269 | -10 | $3,284 | $5,657,579 | 3 | Warner Bros. | false | false |
| 10 | 10 | Astro Boy | $809,805 | +22.1% | 418 | -6 | $1,937 | $4,801,620 | 3 | Entertainment One | false | false |
| 11 | 6 | My Name Is Khan | $694,547 | -52.8% | 95 | +4 | $7,311 | $3,034,126 | 2 | 20th Century Fox International | false | false |
| 12 | 8 | A Single Man | $584,663 | -25.8% | 85 | +6 | $6,878 | $1,961,277 | 2 | Icon Film Distribution | false | false |
| 13 | 11 | Sherlock Holmes | $331,388 | -46.2% | 198 | -94 | $1,673 | $39,795,286 | 9 | Warner Bros. | false | false |
| 14 | 12 | Youth in Revolt | $238,386 | -58.8% | 218 | -62 | $1,093 | $2,975,566 | 3 | Momentum Pictures | false | false |
| 15 | - | The Last Station 2010 Re-release | $209,516 | - | 66 | - | $3,174 | $209,516 | 1 | Optimum Releasing | true | false |
