| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Percy Jackson & the Olympians: The Lightning Thief | $171,910 | -30% | 43 | - | $3,997 | $535,231 | 2 | 20th Century Fox International | false | false |
| 2 | 1 | The Wolfman | $167,226 | -48.8% | 48 | - | $3,483 | $639,109 | 2 | Universal Pictures International (UPI) | false | false |
| 3 | 4 | Avatar | $95,226 | -37.5% | 64 | - | $1,487 | $4,968,359 | 10 | 20th Century Fox International | false | false |
| 4 | 5 | Old Dogs | $76,551 | -38.5% | 42 | - | $1,822 | $985,468 | 4 | Walt Disney Pictures | false | false |
| 5 | 3 | Valentine's Day | $73,812 | -54.7% | 28 | - | $2,636 | $299,976 | 2 | Warner Bros. | false | false |
| 6 | - | The Lovely Bones | $71,099 | - | 28 | - | $2,539 | $71,099 | 1 | Paramount Pictures International | true | false |
| 7 | - | Saw VI | $62,438 | - | 25 | - | $2,497 | $62,438 | 1 | Walt Disney Pictures | true | false |
| 8 | - | Toy Story 2009 Re-release | $60,912 | - | 11 | - | $5,537 | $60,912 | 1 | Walt Disney Pictures | true | false |
| 9 | - | The Hurt Locker | $45,936 | - | 15 | - | $3,062 | $45,936 | 1 | N/A | true | false |
| 10 | - | 9 | $30,213 | - | 20 | - | $1,510 | $30,213 | 1 | N/A | true | false |
| 11 | 6 | Invictus | $13,536 | -61.4% | 20 | - | $676 | $171,524 | 3 | Warner Bros. | false | false |
| 12 | - | Blackout 2009 Re-release | $12,804 | - | 15 | - | $853 | $153,272 | 5 | N/A | false | false |
| 13 | - | An Education | $10,003 | - | 4 | - | $2,500 | $10,003 | 1 | Sony Pictures Releasing | true | false |
| 14 | 7 | I Hate Valentine's Day | $7,678 | -71.4% | 12 | - | $639 | $97,251 | 3 | N/A | false | false |
| 15 | 9 | Tooth Fairy | $5,985 | -74.5% | 36 | - | $166 | $894,634 | 6 | 20th Century Fox International | false | false |
| 16 | 10 | Astro Boy | $5,083 | -73.5% | 25 | - | $203 | $208,045 | 4 | N/A | false | false |
| 17 | 12 | Ninja Assassin | $4,799 | -50.1% | 12 | - | $399 | $139,193 | 5 | Warner Bros. | false | false |
| 18 | - | The Code | $3,331 | - | 19 | - | $175 | $99,554 | 6 | N/A | false | false |
| 19 | - | The Milk of Sorrow | $3,169 | - | 2 | - | $1,584 | $756,727 | 50 | N/A | false | false |
| 20 | 13 | El ratón Pérez 2 | $2,124 | -74.2% | 27 | - | $78 | $69,467 | 3 | Walt Disney Pictures | false | false |
| 21 | 8 | All the Boys Love Mandy Lane | $1,356 | -94.5% | 14 | - | $96 | $104,353 | 3 | N/A | false | false |
| 22 | 15 | The Imaginarium of Doctor Parnassus | $643 | -83.1% | 1 | -2 | $643 | $101,481 | 4 | Sony Pictures Releasing | false | false |
| 23 | - | Inglourious Basterds | $553 | - | 25 | - | $22 | $465,891 | 20 | Universal Pictures International (UPI) | false | false |
| 24 | 16 | Alvin and the Chipmunks: The Squeakquel | $483 | -71.7% | 50 | - | $9 | $1,393,474 | 8 | 20th Century Fox International | false | false |
| 25 | 14 | Up in the Air | $342 | -94.2% | 14 | - | $24 | $207,223 | 5 | Paramount Pictures International | false | false |
| 26 | - | The Princess and the Frog | $250 | - | 40 | - | $6 | $689,903 | 9 | Walt Disney Pictures | false | false |
