| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Avatar | $965,566 | -6% | 108 | -21 | $8,940 | $21,499,808 | 10 | 20th Century Fox International | false | false |
| 2 | 1 | Valentine's Day | $614,420 | -41% | 106 | - | $5,796 | $2,102,926 | 2 | Warner Bros. | false | false |
| 3 | - | Shutter Island | $442,346 | - | 50 | - | $8,846 | $442,346 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 3 | Percy Jackson & the Olympians: The Lightning Thief | $401,852 | -10.7% | 96 | - | $4,185 | $1,016,813 | 2 | Warner Bros. | false | false |
| 5 | - | Cloudy with a Chance of Meatballs | $398,237 | - | 80 | - | $4,977 | $585,298 | 1 | Sony Pictures Releasing | true | false |
| 6 | 4 | The Princess and the Frog | $379,429 | +23.1% | 125 | -12 | $3,035 | $1,612,495 | 3 | Walt Disney Pictures | false | false |
| 7 | - | Gangsterboys | $332,625 | - | 39 | - | $8,528 | $332,625 | 1 | Independent Films | true | false |
| 8 | - | Eep! 2010 Re-release | $243,612 | - | 87 | - | $2,800 | $309,852 | 1 | Independent Films | true | false |
| 9 | 5 | The Wolfman | $155,769 | -30.4% | 49 | -5 | $3,178 | $458,530 | 2 | Universal Pictures International (UPI) | false | false |
| 10 | 8 | Alvin and the Chipmunks: The Squeakquel | $153,478 | +48.2% | 107 | - | $1,434 | $6,451,232 | 9 | Warner Bros. | false | false |
| 11 | 6 | Edge of Darkness | $102,723 | -23.5% | 65 | -7 | $1,580 | $998,459 | 4 | Entertainment One | false | false |
| 12 | 10 | A Single Man | $82,839 | -2.1% | 20 | - | $4,141 | $370,858 | 3 | Cinéart | false | false |
| 13 | 7 | Sherlock Holmes | $79,728 | -33.2% | 57 | -18 | $1,398 | $3,894,039 | 7 | Warner Bros. | false | false |
| 14 | - | Nine | $78,022 | - | 39 | - | $2,000 | $110,258 | 1 | Paradiso Entertainment | true | false |
| 15 | 12 | The Spy Next Door 2010 Re-release | $73,838 | -4.7% | 44 | - | $1,678 | $338,819 | 3 | A-Film Distribution | false | false |
| 16 | 9 | Love Life | $70,668 | -21.2% | 73 | -17 | $968 | $12,326,262 | 13 | Benelux Film Distributors | false | false |
| 17 | 11 | The Girl Who Played with Fire | $68,105 | -12.8% | 34 | -12 | $2,003 | $874,210 | 5 | Benelux Film Distributors | false | false |
| 18 | 15 | A Prophet | $59,525 | -6.9% | 25 | -1 | $2,381 | $272,672 | 3 | Cinemien | false | false |
| 19 | 20 | A Serious Man | $46,622 | -7.5% | 19 | -3 | $2,453 | $524,566 | 5 | Universal Pictures International (UPI) | false | false |
| 20 | 14 | My Name Is Khan | $41,262 | -38.3% | 5 | - | $8,252 | $127,875 | 2 | Warner Bros. | false | false |
