| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Avatar | $50,663 | -43.1% | 18 | - | $2,814 | $1,662,265 | 9 | 20th Century Fox International | false | false |
| 2 | 1 | Alvin and the Chipmunks: The Squeakquel | $42,023 | -63.5% | 13 | - | $3,232 | $352,733 | 3 | 20th Century Fox International | false | false |
| 3 | 3 | Did You Hear About the Morgans? | $25,413 | -28.5% | 8 | - | $3,176 | $72,083 | 2 | Sony Pictures Releasing | false | false |
| 4 | 5 | Sherlock Holmes | $8,558 | -33.2% | 9 | - | $950 | $243,340 | 6 | Warner Bros. | false | false |
| 5 | 4 | The Men Who Stare at Goats | $8,389 | -41.3% | 4 | - | $2,097 | $55,289 | 3 | N/A | false | false |
| 6 | - | Cloudy with a Chance of Meatballs | $7,831 | - | 13 | - | $602 | $7,831 | 1 | Sony Pictures Releasing | true | false |
| 7 | - | Edge of Darkness | $7,608 | - | 4 | - | $1,902 | $9,196 | 1 | N/A | true | false |
| 8 | 9 | The Book of Eli | $7,030 | -30.7% | 6 | - | $1,171 | $79,019 | 4 | N/A | false | false |
| 9 | 7 | The Other Man | $6,203 | -42.4% | 6 | - | $1,033 | $23,191 | 2 | N/A | false | false |
| 10 | 8 | Up in the Air | $5,799 | -43.4% | 5 | - | $1,159 | $109,502 | 5 | United International Pictures | false | false |
| 11 | 6 | The Princess and the Frog | $5,057 | -58% | 9 | - | $561 | $76,627 | 4 | Walt Disney Pictures | false | false |
| 12 | 10 | Gamer | $3,175 | -60% | 6 | - | $529 | $16,680 | 2 | N/A | false | false |
| 13 | 13 | A Serious Man | $1,877 | -10% | 1 | - | $1,877 | $5,734 | 2 | N/A | false | false |
