| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $399,397 | -22.8% | 79 | -25 | $5,055 | $11,889,017 | 9 | 20th Century Fox International | false | false |
| 2 | - | The Wolfman | $251,714 | - | 96 | - | $2,622 | $253,360 | 1 | United International Pictures | true | false |
| 3 | - | Percy Jackson & the Olympians: The Lightning Thief | $219,213 | - | 89 | - | $2,463 | $219,213 | 1 | 20th Century Fox International | true | false |
| 4 | - | Valentine's Day | $104,605 | - | 42 | - | $2,490 | $104,605 | 1 | Warner Bros. | true | false |
| 5 | 2 | Tooth Fairy | $83,952 | -41.7% | 49 | -4 | $1,713 | $775,484 | 4 | 20th Century Fox International | false | false |
| 6 | 5 | Invictus | $58,307 | -35.1% | 32 | -14 | $1,822 | $182,801 | 2 | Warner Bros. | false | false |
| 7 | 3 | Old Dogs | $47,205 | -53.7% | 44 | -3 | $1,072 | $994,940 | 6 | Walt Disney Pictures | false | false |
| 8 | - | The Hurt Locker | $29,737 | - | 13 | - | $2,287 | $29,737 | 1 | Cineplex | true | false |
| 9 | 4 | Sherlock Holmes | $20,959 | -77.1% | 27 | -47 | $776 | $1,640,157 | 6 | Warner Bros. | false | false |
| 10 | 8 | Up in the Air | $15,960 | -54.6% | 17 | -1 | $938 | $202,426 | 4 | United International Pictures | false | false |
| 11 | 10 | Nine | $14,788 | -44.2% | 9 | - | $1,643 | $103,681 | 3 | Sony Pictures Releasing | false | false |
| 12 | 7 | Broken Embraces | $13,848 | -62.5% | 14 | -6 | $989 | $67,516 | 2 | United International Pictures | false | false |
| 13 | 6 | Alvin and the Chipmunks: The Squeakquel | $12,522 | -66.3% | 44 | -34 | $284 | $1,336,609 | 7 | 20th Century Fox International | false | false |
| 14 | 14 | Departures | $7,038 | -31.5% | 4 | -1 | $1,759 | $96,438 | 5 | Cine Colombia | false | false |
| 15 | 11 | The Princess and the Frog | $7,008 | -67.1% | 31 | -27 | $226 | $1,806,763 | 8 | Walt Disney Pictures | false | false |
| 16 | 9 | Ninja Assassin | $2,504 | -91.9% | 5 | -27 | $500 | $120,333 | 3 | Warner Bros. | false | false |
| 17 | 13 | Zombieland | $2,415 | -86.4% | 8 | -9 | $301 | $158,307 | 5 | Sony Pictures Releasing | false | false |
| 18 | 15 | Astro Boy | $2,407 | -63.8% | 11 | -11 | $218 | $69,274 | 5 | Cine Colombia | false | false |
| 19 | 12 | Paranormal Activity | $1,876 | -90.3% | 2 | -23 | $938 | $1,261,145 | 7 | Cine Colombia | false | false |
| 20 | 16 | The Stepfather | $546 | -88.2% | 1 | -5 | $546 | $90,670 | 10 | Sony Pictures Releasing | false | false |
| 21 | 17 | The Soloist | $534 | -72.6% | 3 | - | $178 | $53,542 | 5 | United International Pictures | false | false |
