| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $1,563,033 | -6% | 431 | -16 | $3,626 | $37,775,814 | 7 | 20th Century Fox International | false | false |
| 2 | 2 | Tooth Fairy | $973,427 | -24.9% | 385 | -14 | $2,528 | $5,574,787 | 3 | 20th Century Fox International | false | false |
| 3 | - | The Book of Eli | $872,625 | - | 300 | - | $2,908 | $872,625 | 1 | Sony Pictures Releasing | true | false |
| 4 | - | It's Complicated | $755,868 | - | 350 | - | $2,159 | $1,003,405 | 1 | Universal Pictures International (UPI) | true | false |
| 5 | 5 | The Fourth Kind | $374,273 | -23.6% | 224 | -1 | $1,670 | $1,285,508 | 2 | Gussi Films | false | false |
| 6 | 6 | Invictus | $354,050 | -19% | 201 | - | $1,761 | $1,150,515 | 2 | Warner Bros. | false | false |
| 7 | 4 | Up in the Air | $351,792 | -40.3% | 250 | -1 | $1,407 | $1,361,849 | 2 | Paramount Pictures International | false | false |
| 8 | 3 | Sherlock Holmes | $348,354 | -43.3% | 367 | -66 | $949 | $10,845,245 | 5 | Warner Bros. | false | false |
| 9 | - | Astro Boy | $245,340 | - | 149 | - | $1,646 | $331,730 | 1 | N/A | true | false |
| 10 | - | Regresa | $204,084 | - | 230 | - | $887 | $762,881 | 2 | N/A | false | false |
| 11 | 11 | Law Abiding Citizen | $149,718 | +27.7% | 129 | -8 | $1,160 | $1,626,645 | 4 | N/A | false | false |
| 12 | 7 | Alvin and the Chipmunks: The Squeakquel | $145,573 | -47.1% | 237 | -126 | $614 | $9,901,105 | 6 | 20th Century Fox International | false | false |
| 13 | 9 | Paranormal Activity | $137,469 | -39.8% | 182 | -66 | $755 | $5,663,059 | 6 | Gussi Films | false | false |
| 14 | 12 | All About Steve | $97,623 | +8.8% | 118 | +33 | $827 | $828,614 | 5 | 20th Century Fox International | false | false |
| 15 | 8 | Did You Hear About the Morgans? | $95,729 | -59.4% | 96 | -110 | $997 | $1,122,284 | 3 | Sony Pictures Releasing | false | false |
| 16 | 10 | Zombieland | $87,823 | -32.2% | 109 | -52 | $805 | $958,297 | 4 | Sony Pictures Releasing | false | false |
| 17 | - | AAA, la película: Sin límite en el tiempo | $74,712 | - | 226 | - | $330 | $371,439 | 2 | Videocine | false | false |
| 18 | 21 | Mutant Chronicles | $53,250 | +155.7% | 94 | +55 | $566 | $317,594 | 4 | Videocine | false | false |
| 19 | 23 | Labor Pains | $52,147 | +293.3% | 72 | +31 | $724 | $572,318 | 4 | N/A | false | false |
| 20 | - | Motherhood | $48,753 | - | 40 | - | $1,218 | $66,770 | 1 | Gussi Films | true | false |
| 21 | 14 | Everybody's Fine | $46,783 | -35.1% | 82 | -18 | $570 | $1,332,039 | 6 | Walt Disney Pictures | false | false |
| 22 | 13 | Case 39 | $37,554 | -49.5% | 54 | -49 | $695 | $3,308,274 | 9 | Paramount Pictures International | false | false |
| 23 | - | Departures | $31,458 | - | 20 | - | $1,572 | $42,384 | 1 | N/A | true | false |
| 24 | 16 | The Stepfather | $30,802 | -25.1% | 80 | +1 | $385 | $558,049 | 8 | Sony Pictures Releasing | false | false |
| 25 | - | A Serious Man | $29,797 | - | 15 | - | $1,986 | $38,497 | 1 | Universal Pictures International (UPI) | true | false |
| 26 | 19 | Ninja Assassin | $25,868 | +18.6% | 27 | -46 | $958 | $253,596 | 3 | Warner Bros. | false | false |
| 27 | 15 | The Princess and the Frog | $21,595 | -50.7% | 56 | -43 | $385 | $6,059,800 | 8 | Walt Disney Pictures | false | false |
| 28 | 22 | Pandorum | $13,155 | -18.4% | 32 | -34 | $411 | $182,109 | 3 | Gussi Films | false | false |
| 29 | 25 | Julie & Julia | $13,049 | +54.5% | 28 | +14 | $466 | $554,914 | 15 | Sony Pictures Releasing | false | false |
| 30 | 24 | New York, I Love You | $9,095 | -4.8% | 20 | +5 | $454 | $343,194 | 7 | N/A | false | false |
| 31 | 26 | Nikté | $5,276 | -14.6% | 22 | -1 | $239 | $1,300,855 | 7 | Universal Pictures International (UPI) | false | false |
| 32 | 20 | The Box | $4,907 | -76.6% | 16 | -41 | $306 | $1,296,123 | 8 | Videocine | false | false |
| 33 | 17 | Fame | $4,382 | -86.9% | 18 | -47 | $243 | $229,773 | 3 | N/A | false | false |
| 34 | - | Love on a Weekend | $3,693 | - | 40 | - | $92 | $30,615 | 2 | N/A | false | false |
| 35 | 28 | Opium: Diary of a Madwoman | $3,574 | -14.8% | 3 | - | $1,191 | $43,547 | 4 | N/A | false | false |
| 36 | 27 | The Milk of Sorrow | $2,868 | -53.6% | 2 | -6 | $1,434 | $35,485 | 3 | N/A | false | false |
| 37 | 29 | Paris | $1,199 | -48.6% | 5 | - | $239 | $72,137 | 8 | N/A | false | false |
| 38 | 30 | Lemon Tree | $812 | -60.3% | 1 | -2 | $812 | $50,936 | 6 | N/A | false | false |
| 39 | 32 | 2012 | $399 | -65.1% | 5 | -5 | $79 | $19,423,924 | 12 | Sony Pictures Releasing | false | false |
