| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $46,401 | +13.3% | 7 | -1 | $6,628 | $718,866 | 7 | 20th Century Fox International | false | false |
| 2 | 2 | Invictus | $22,735 | +13.8% | 8 | - | $2,841 | $67,748 | 2 | Warner Bros. | false | false |
| 3 | 3 | Sherlock Holmes | $15,663 | -16.2% | 7 | - | $2,237 | $130,871 | 3 | Warner Bros. | false | false |
| 4 | 6 | Old Dogs | $15,550 | +28.6% | 5 | - | $3,110 | $41,753 | 2 | Walt Disney Pictures | false | false |
| 5 | 4 | It's Complicated | $13,458 | -8.4% | 7 | - | $1,922 | $109,359 | 3 | United International Pictures | false | false |
| 6 | 5 | Up in the Air | $8,974 | -27.4% | 8 | - | $1,121 | $81,527 | 2 | Paramount Pictures International | false | false |
| 7 | - | Easy Virtue | $7,716 | - | 4 | - | $1,929 | $7,716 | 1 | Sony Pictures Releasing | true | false |
| 8 | 8 | Alvin and the Chipmunks: The Squeakquel | $7,669 | +3.7% | 5 | - | $1,533 | $113,369 | 5 | 20th Century Fox International | false | false |
| 9 | 7 | The Girl with the Dragon Tattoo | $7,301 | -13.5% | 4 | - | $1,825 | $40,037 | 2 | N/A | false | false |
| 10 | - | Astro Boy | $6,153 | - | 4 | - | $1,538 | $6,153 | 1 | N/A | true | false |
| 11 | 10 | The Princess and the Frog | $3,636 | +8.1% | 5 | - | $727 | $60,530 | 4 | Walt Disney Pictures | false | false |
| 12 | - | Funny People | $2,860 | - | 2 | - | $1,430 | $2,860 | 1 | Universal Pictures International (UPI) | true | false |
| 13 | 11 | Paranormal Activity | $2,368 | -25.8% | 2 | -1 | $1,184 | $52,706 | 5 | N/A | false | false |
| 14 | 9 | The Young Victoria | $2,342 | -54.2% | 3 | -1 | $780 | $29,333 | 3 | N/A | false | false |
| 15 | - | My Stars | $1,612 | - | 3 | - | $537 | $1,612 | 1 | N/A | true | false |
| 16 | 13 | Zombieland | $791 | -7.7% | 1 | -2 | $791 | $22,400 | 4 | Sony Pictures Releasing | false | false |
| 17 | 14 | The Twilight Saga: New Moon | $780 | +2.1% | 3 | - | $260 | $173,313 | 9 | N/A | false | false |
| 18 | 17 | My Life in Ruins | $559 | +18.9% | 1 | - | $559 | $46,051 | 6 | N/A | false | false |
| 19 | - | Emma's Bliss | $290 | - | 1 | - | $290 | $290 | 1 | N/A | true | false |
| 20 | 12 | All About Steve | $278 | -69.2% | 1 | -1 | $278 | $52,792 | 4 | 20th Century Fox International | false | false |
