| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $585,541 | -10% | 122 | -1 | $4,799 | $10,106,506 | 7 | 20th Century Fox International | false | false |
| 2 | 2 | Tooth Fairy | $184,621 | -7.5% | 53 | -2 | $3,483 | $457,177 | 2 | 20th Century Fox International | false | false |
| 3 | 3 | Sherlock Holmes | $134,173 | -26% | 86 | -4 | $1,560 | $1,397,357 | 4 | Warner Bros. | false | false |
| 4 | 4 | Old Dogs | $115,862 | +12.9% | 47 | +1 | $2,465 | $752,086 | 4 | Walt Disney Pictures | false | false |
| 5 | 5 | Alvin and the Chipmunks: The Squeakquel | $56,847 | -26.7% | 80 | -1 | $710 | $1,223,695 | 5 | 20th Century Fox International | false | false |
| 6 | - | Ninja Assassin | $51,271 | - | 32 | - | $1,602 | $51,271 | 1 | Warner Bros. | true | false |
| 7 | 6 | Paranormal Activity | $40,212 | -42% | 7 | -57 | $5,744 | $1,170,647 | 5 | Cine Colombia | false | false |
| 8 | 8 | Up in the Air | $39,765 | -24% | 18 | - | $2,209 | $115,894 | 2 | United International Pictures | false | false |
| 9 | 7 | The Princess and the Frog | $35,366 | -43.5% | 76 | -23 | $465 | $1,702,329 | 6 | Walt Disney Pictures | false | false |
| 10 | - | Nine | $32,321 | - | 9 | - | $3,591 | $32,321 | 1 | Sony Pictures Releasing | true | false |
| 11 | 10 | Departures | $14,783 | <0.1% | 4 | - | $3,695 | $63,135 | 3 | Cine Colombia | false | false |
| 12 | 12 | Astro Boy | $8,297 | -13.9% | 25 | - | $331 | $56,335 | 3 | Cine Colombia | false | false |
| 13 | 9 | Zombieland | $7,147 | -67.9% | 16 | -15 | $446 | $127,899 | 3 | Sony Pictures Releasing | false | false |
| 14 | 11 | The Soloist | $6,216 | -40.9% | 5 | - | $1,243 | $44,793 | 3 | United International Pictures | false | false |
| 15 | - | Shadows | $5,220 | - | 8 | - | $652 | $21,802 | 2 | Cine Colombia | false | false |
| 16 | 14 | The Stepfather | $1,259 | -11.8% | 3 | - | $419 | $83,287 | 8 | Sony Pictures Releasing | false | false |
| 17 | 15 | Inglourious Basterds | $483 | -34.7% | 1 | - | $483 | $424,169 | 14 | United International Pictures | false | false |
