| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Avatar | $48,500,000 | $50,306,217 | +$1,806,217 | +3.7% | 3,422 | $429,040,000 | $430,846,514 | 4 | Twentieth Century Fox | - |
| 2 | 2 | - | Sherlock Holmes | $16,610,000 | $16,585,327 | -$24,673 | -0.1% | 3,626 | $165,178,000 | $165,153,093 | 3 | Warner Bros. | - |
| 3 | 3 | - | Alvin and the Chipmunks: The Squeakquel | $16,300,000 | $16,566,489 | +$266,489 | +1.6% | 3,641 | $178,184,000 | $178,451,165 | 3 | Twentieth Century Fox | - |
| 4 | 4 | - | Daybreakers | $15,000,000 | $15,146,692 | +$146,692 | +1% | 2,523 | $15,000,000 | $15,146,692 | 1 | Lionsgate | - |
| 5 | 5 | - | It's Complicated | $11,007,000 | $11,007,875 | +$875 | <0.1% | 2,955 | $76,370,000 | $76,370,540 | 3 | Universal Pictures | - |
| 6 | 6 | - | Leap Year | $9,165,000 | $9,202,815 | +$37,815 | +0.4% | 2,511 | $9,165,000 | $9,202,815 | 1 | Universal Pictures | - |
| 7 | 7 | - | The Blind Side | $7,750,000 | $7,531,467 | -$218,533 | -2.8% | 2,880 | $219,197,000 | $218,978,376 | 8 | Warner Bros. | - |
| 8 | 8 | - | Up in the Air | $7,100,000 | $7,159,294 | +$59,294 | +0.8% | 2,218 | $54,700,000 | $54,801,035 | 6 | Paramount Pictures | - |
| 9 | 9 | - | Youth in Revolt | $7,000,000 | $6,888,334 | -$111,666 | -1.6% | 1,873 | $7,000,000 | $6,888,334 | 1 | Dimension Films | - |
| 10 | 10 | - | The Princess and the Frog | $4,700,000 | $4,651,156 | -$48,844 | -1% | 2,620 | $92,600,000 | $92,546,727 | 7 | Walt Disney Studios Motion Pictures | - |
| 11 | 12 | +1 | Invictus | $1,715,000 | $1,722,246 | +$7,246 | +0.4% | 1,340 | $33,500,000 | $33,506,889 | 5 | Warner Bros. | - |
| 12 | 13 | +1 | The Twilight Saga: New Moon | $1,688,000 | $1,703,809 | +$15,809 | +0.9% | 1,167 | $290,727,400 | $290,743,279 | 8 | Summit Entertainment | - |
| 13 | 14 | +1 | Nine | $1,618,000 | $1,614,900 | -$3,100 | -0.2% | 1,060 | $16,840,000 | $16,837,007 | 4 | The Weinstein Company | - |
| 14 | 15 | +1 | Did You Hear About the Morgans? | $1,600,000 | $1,546,172 | -$53,828 | -3.4% | 1,820 | $28,400,000 | $28,346,423 | 4 | Sony Pictures Releasing | - |
| 15 | 16 | +1 | The Young Victoria | $1,097,000 | $1,180,595 | +$83,595 | +7.6% | 476 | $4,505,600 | $4,588,617 | 4 | Apparition | - |
| 16 | 18 | +2 | Precious | $460,000 | $464,718 | +$4,718 | +1% | 408 | $44,310,000 | $44,311,459 | 10 | Lionsgate | - |
| 17 | 19 | +2 | Crazy Heart | $435,000 | $462,126 | +$27,126 | +6.2% | 33 | $1,219,600 | $1,246,747 | 4 | Fox Searchlight Pictures | - |
| 18 | 22 | +4 | Brothers | $380,000 | $364,633 | -$15,367 | -4% | 428 | $28,210,000 | $28,198,793 | 6 | Lionsgate | - |
| 19 | 23 | +4 | A Single Man | $358,000 | $359,845 | +$1,845 | +0.5% | 48 | $2,284,000 | $2,286,364 | 5 | The Weinstein Company | - |
| 20 | 25 | +5 | Fantastic Mr. Fox | $275,000 | $285,239 | +$10,239 | +3.7% | 265 | $19,548,800 | $19,559,123 | 9 | Twentieth Century Fox | - |
| 21 | 26 | +5 | The Road | $247,000 | $253,455 | +$6,455 | +2.6% | 207 | $7,533,432 | $7,361,887 | 7 | Dimension Films | - |
| 22 | 30 | +8 | Couples Retreat | $142,000 | $147,750 | +$5,750 | +4% | 197 | $108,726,000 | $108,731,660 | 14 | Universal Pictures | - |
| 23 | 31 | +8 | The Men Who Stare at Goats | $120,000 | $120,976 | +$976 | +0.8% | 198 | $32,157,500 | $32,158,526 | 10 | Overture Films | - |
| 24 | 32 | +8 | Law Abiding Citizen | $110,000 | $110,626 | +$626 | +0.6% | 194 | $73,106,000 | $73,106,880 | 13 | Overture Films | - |
| 25 | 36 | +11 | Crazy on the Outside | $75,400 | $64,438 | -$10,962 | -14.5% | 75 | $75,400 | $64,438 | 1 | Freestyle Releasing | - |
| 26 | 37 | +11 | The Boondock Saints II: All Saints Day | $62,300 | $60,974 | -$1,326 | -2.1% | 62 | $10,084,000 | $10,082,650 | 11 | Apparition | - |
| 27 | 42 | +15 | Bad Lieutenant: Port of Call New Orleans | $45,800 | $42,814 | -$2,986 | -6.5% | 43 | $1,500,300 | $1,497,352 | 8 | First Look International | - |
| 28 | 41 | +13 | Astro Boy | $42,000 | $44,287 | +$2,287 | +5.4% | 106 | $19,513,300 | $19,515,628 | 12 | Summit Entertainment | - |
| 29 | 44 | +15 | Me and Orson Welles | $36,600 | $35,598 | -$1,002 | -2.7% | 35 | $1,022,100 | $1,021,113 | 7 | Freestyle Releasing | - |
| 30 | 43 | +13 | The Lovely Bones | $35,000 | $38,572 | +$3,572 | +10.2% | 3 | $444,000 | $448,080 | 5 | DreamWorks | - |
| 31 | 47 | +16 | Paranormal Activity | $27,000 | $27,023 | +$23 | <0.1% | 103 | $107,900,000 | $107,901,736 | 16 | Paramount Pictures | - |
| 32 | 48 | +16 | The Messenger | $16,841 | $17,386 | +$545 | +3.2% | 22 | $680,400 | $680,966 | 9 | Oscilloscope | - |
| 33 | 56 | +23 | Sweetgrass | $10,400 | $9,870 | -$530 | -5.1% | 1 | $13,300 | $12,864 | 1 | The Cinema Guild | - |
