| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $235,380 | -20.3% | 72 | - | $3,269 | $3,456,777 | 5 | 20th Century Fox International | false | false |
| 2 | - | Tooth Fairy | $225,301 | - | 36 | - | $6,258 | $225,301 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | Sherlock Holmes | $136,270 | -53.5% | 48 | - | $2,838 | $557,802 | 2 | Warner Bros. | false | false |
| 4 | 3 | Alvin and the Chipmunks: The Squeakquel | $128,729 | -47.6% | 50 | - | $2,574 | $1,116,425 | 3 | 20th Century Fox International | false | false |
| 5 | - | Cirque du Freak: The Vampire's Assistant | $77,105 | - | 30 | - | $2,570 | $77,105 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | - | The Stepfather | $54,073 | - | 25 | - | $2,162 | $54,073 | 1 | Sony Pictures Releasing | true | false |
| 7 | 4 | [Rec]² | $54,011 | -44.4% | 26 | - | $2,077 | $394,770 | 3 | N/A | false | false |
| 8 | - | The Code | $40,930 | - | 19 | - | $2,154 | $40,930 | 1 | N/A | true | false |
| 9 | 5 | Paranormal Activity | $38,577 | -48.3% | 25 | - | $1,543 | $623,558 | 4 | N/A | false | false |
| 10 | 6 | The Princess and the Frog | $16,508 | -69.5% | 40 | - | $412 | $654,118 | 4 | Walt Disney Pictures | false | false |
| 11 | 9 | The Soloist | $7,398 | -45.8% | 5 | - | $1,479 | $28,457 | 2 | Universal Pictures International (UPI) | false | false |
| 12 | 7 | Couples Retreat | $5,501 | -79.3% | 26 | - | $211 | $305,208 | 4 | Universal Pictures International (UPI) | false | false |
| 13 | 11 | Smother | $1,325 | -59.1% | 16 | - | $82 | $156,836 | 12 | N/A | false | false |
| 14 | 8 | Zombieland | $114 | -99.2% | 2 | -23 | $57 | $118,548 | 3 | Sony Pictures Releasing | false | false |
