| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Avatar | $68,300,000 | $68,490,688 | +$190,688 | +0.3% | 3,461 | $352,111,000 | $352,114,898 | 3 | Twentieth Century Fox | - |
| 2 | 2 | - | Sherlock Holmes | $38,385,000 | $36,612,481 | -$1,772,519 | -4.6% | 3,626 | $140,675,000 | $138,715,437 | 2 | Warner Bros. | - |
| 3 | 3 | - | Alvin and the Chipmunks: The Squeakquel | $36,600,000 | $35,189,653 | -$1,410,347 | -3.9% | 3,747 | $157,345,000 | $155,916,935 | 2 | Twentieth Century Fox | - |
| 4 | 4 | - | It's Complicated | $18,700,000 | $18,802,965 | +$102,965 | +0.6% | 2,897 | $59,105,000 | $59,178,840 | 2 | Universal Pictures | - |
| 5 | 5 | - | The Blind Side | $12,650,000 | $11,912,749 | -$737,251 | -5.8% | 2,926 | $209,052,000 | $208,476,067 | 7 | Warner Bros. | - |
| 6 | 6 | - | Up in the Air | $11,350,000 | $10,720,052 | -$629,948 | -5.6% | 1,895 | $45,020,000 | $44,375,265 | 5 | Paramount Pictures | - |
| 7 | 7 | - | The Princess and the Frog | $10,013,000 | $9,824,311 | -$188,689 | -1.9% | 3,328 | $86,085,000 | $85,859,339 | 6 | Walt Disney Studios Motion Pictures | - |
| 8 | 8 | - | Did You Hear About the Morgans? | $5,200,000 | $4,932,338 | -$267,662 | -5.1% | 2,718 | $25,620,000 | $25,312,384 | 3 | Sony Pictures Releasing | - |
| 9 | 10 | +1 | Nine | $4,250,000 | $3,901,203 | -$348,797 | -8.2% | 1,412 | $14,047,000 | $13,745,956 | 3 | The Weinstein Company | - |
| 10 | 9 | -1 | Invictus | $4,130,000 | $3,909,312 | -$220,688 | -5.3% | 2,170 | $30,755,000 | $30,586,445 | 4 | Warner Bros. | - |
| 11 | 11 | - | The Twilight Saga: New Moon | $3,605,000 | $3,442,263 | -$162,737 | -4.5% | 1,627 | $287,753,000 | $287,954,655 | 7 | Summit Entertainment | - |
| 12 | 13 | +1 | Brothers | $1,290,000 | $1,192,134 | -$97,866 | -7.6% | 858 | $27,510,000 | $27,414,913 | 5 | Lionsgate | - |
| 13 | 14 | +1 | 2012 | $1,125,000 | $1,093,128 | -$31,872 | -2.8% | 800 | $163,466,000 | $163,442,129 | 8 | Sony Pictures Releasing | - |
| 14 | 16 | +2 | Precious | $950,000 | $924,203 | -$25,797 | -2.7% | 629 | $43,520,000 | $43,492,192 | 9 | Lionsgate | - |
| 15 | 15 | - | The Young Victoria | $894,000 | $1,011,466 | +$117,466 | +13.1% | 193 | $2,454,000 | $2,980,856 | 3 | Apparition | - |
| 16 | 17 | +1 | Old Dogs | $733,000 | $711,002 | -$21,998 | -3% | 620 | $47,259,000 | $47,239,575 | 6 | Walt Disney Studios Motion Pictures | - |
| 17 | 19 | +2 | The Road | $560,000 | $542,635 | -$17,365 | -3.1% | 306 | $6,791,000 | $6,858,313 | 6 | Dimension Films | - |
| 18 | 18 | - | A Christmas Carol | $540,000 | $554,866 | +$14,866 | +2.8% | 981 | $137,429,000 | $137,443,917 | 9 | Walt Disney Studios Motion Pictures | - |
| 19 | 20 | +1 | A Single Man | $508,000 | $486,958 | -$21,042 | -4.1% | 46 | $1,730,000 | $1,731,649 | 4 | The Weinstein Company | - |
| 20 | 21 | +1 | Fantastic Mr. Fox | $482,000 | $478,633 | -$3,367 | -0.7% | 274 | $19,126,000 | $19,123,189 | 8 | Twentieth Century Fox | - |
| 21 | 22 | +1 | Broken Embraces | $464,000 | $439,901 | -$24,099 | -5.2% | 71 | $2,064,000 | $2,022,655 | 7 | Sony Pictures Classics | - |
| 22 | 26 | +4 | An Education | $306,000 | $271,834 | -$34,166 | -11.2% | 151 | $7,937,000 | $7,883,524 | 13 | Sony Pictures Classics | - |
| 23 | 28 | +5 | Crazy Heart | $236,000 | $220,988 | -$15,012 | -6.4% | 12 | $716,000 | $702,188 | 3 | Fox Searchlight Pictures | - |
| 24 | 29 | +5 | Couples Retreat | $215,000 | $214,295 | -$705 | -0.3% | 222 | $108,512,000 | $108,511,760 | 13 | Universal Pictures | - |
| 25 | 31 | +6 | Law Abiding Citizen | $173,000 | $164,586 | -$8,414 | -4.9% | 205 | $72,937,000 | $72,928,813 | 12 | Overture Films | - |
| 26 | 23 | -3 | The Imaginarium of Doctor Parnassus | $131,000 | $368,836 | +$237,836 | +181.6% | 48 | $349,000 | $1,029,821 | 2 | Sony Pictures Classics | - |
| 27 | 33 | +6 | The Boondock Saints II: All Saints Day | $117,000 | $118,170 | +$1,170 | +1% | 102 | $9,957,000 | $9,957,954 | 10 | Apparition | - |
| 28 | 34 | +6 | Me and Orson Welles | $101,000 | $92,073 | -$8,927 | -8.8% | 80 | $951,000 | $942,276 | 6 | Freestyle Releasing | - |
| 29 | 36 | +7 | Astro Boy | $77,000 | $74,488 | -$2,512 | -3.3% | 152 | $19,453,000 | $19,452,359 | 11 | Summit Entertainment | - |
| 30 | 38 | +8 | The Lovely Bones | $65,000 | $64,678 | -$322 | -0.5% | 3 | $383,000 | $383,101 | 4 | DreamWorks | - |
| 31 | 40 | +9 | Paranormal Activity | $64,000 | $61,751 | -$2,249 | -3.5% | 145 | $107,856,000 | $107,854,596 | 15 | Paramount Pictures | - |
| 32 | 41 | +9 | The White Ribbon | $61,300 | $59,848 | -$1,452 | -2.4% | 3 | $87,200 | $85,690 | 1 | Sony Pictures Classics | - |
| 33 | 44 | +11 | Bad Lieutenant: Port of Call New Orleans | $50,100 | $44,520 | -$5,580 | -11.1% | 38 | $1,439,000 | $1,433,091 | 7 | First Look International | - |
| 34 | 45 | +11 | The Men Who Stare at Goats | $42,000 | $41,494 | -$506 | -1.2% | 74 | $32,018,000 | $32,018,431 | 9 | Overture Films | - |
| 35 | 48 | +13 | Coco Before Chanel | $23,800 | $20,459 | -$3,341 | -14% | 28 | $6,001,000 | $5,997,682 | 15 | Sony Pictures Classics | - |
| 36 | 50 | +14 | The Messenger | $18,500 | $18,755 | +$255 | +1.4% | 21 | $654,000 | $654,374 | 8 | Oscilloscope | - |
