| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $9,649,320 | -23.8% | 794 | -6 | $12,152 | $44,390,111 | 3 | 20th Century Fox International | false | false |
| 2 | 2 | Alvin and the Chipmunks: The Squeakquel | $2,854,835 | -15.8% | 355 | +3 | $8,041 | $8,402,424 | 2 | 20th Century Fox International | false | false |
| 3 | - | Solomon Kane | $2,144,856 | - | 296 | - | $7,246 | $2,144,856 | 1 | - | true | false |
| 4 | 3 | It's Complicated | $1,388,469 | -36.8% | 327 | +108 | $4,246 | $4,265,939 | 2 | United International Pictures | false | false |
| 5 | - | Ghosts of Girlfriends Past | $1,331,165 | - | 298 | - | $4,466 | $1,331,165 | 1 | TriPictures | true | false |
| 6 | 4 | Zombieland | $628,586 | -55.6% | 250 | - | $2,514 | $2,640,148 | 2 | Sony Pictures Releasing | false | false |
| 7 | 7 | Planet 51 | $607,815 | -35.6% | 287 | -95 | $2,117 | $15,674,370 | 6 | DeAPlaneta | false | false |
| 8 | - | Everybody's Fine | $605,533 | - | 189 | - | $3,203 | $605,533 | 1 | Walt Disney Pictures | true | false |
| 9 | 8 | Cell 211 | $600,942 | -33.9% | 192 | -21 | $3,129 | $13,578,443 | 9 | Paramount Pictures International | false | false |
| 10 | - | Love Happens | $471,846 | - | 198 | - | $2,383 | $471,846 | 1 | N/A | true | false |
| 11 | - | 9 | $450,189 | - | 202 | - | $2,228 | $450,189 | 1 | United International Pictures | true | false |
| 12 | 5 | Fame | $416,982 | -61.2% | 269 | -7 | $1,550 | $2,133,299 | 2 | Filmax | false | false |
| 13 | 6 | Spanish Movie | $404,406 | -58.4% | 242 | -92 | $1,671 | $10,495,191 | 5 | 20th Century Fox International | false | false |
| 14 | 12 | The Flight Before Christmas | $260,770 | -19.5% | 134 | -11 | $1,946 | $945,266 | 2 | Filmax | false | false |
| 15 | 11 | Cloudy with a Chance of Meatballs | $221,974 | -40.1% | 239 | -59 | $928 | $6,470,141 | 5 | Sony Pictures Releasing | false | false |
| 16 | - | The Greatest | $209,821 | - | 93 | - | $2,256 | $209,821 | 1 | N/A | true | false |
| 17 | 10 | Old Dogs | $189,344 | -63.4% | 159 | -130 | $1,190 | $5,475,319 | 5 | Walt Disney Pictures | false | false |
| 18 | 15 | The Hedgehog | $185,051 | -33.8% | 63 | -26 | $2,937 | $1,355,140 | 4 | Alta Films | false | false |
| 19 | 9 | Ninja Assassin | $154,331 | -75.4% | 204 | +1 | $756 | $1,038,222 | 2 | Warner Bros. | false | false |
| 20 | 14 | Where the Wild Things Are | $133,890 | -52.4% | 124 | -26 | $1,079 | $1,147,174 | 3 | Warner Bros. | false | false |
| 21 | 13 | The Twilight Saga: New Moon | $100,375 | -65.2% | 125 | -70 | $803 | $28,527,431 | 7 | - | false | false |
| 22 | 16 | 2012 | $86,560 | -67.8% | 97 | -74 | $892 | $22,487,499 | 8 | Sony Pictures Releasing | false | false |
| 23 | 18 | A Christmas Carol | $58,680 | -57.3% | 75 | -85 | $782 | $8,321,029 | 8 | Walt Disney Pictures | false | false |
| 24 | 20 | Agora | $47,870 | -30.7% | 22 | -9 | $2,175 | $30,245,831 | 13 | 20th Century Fox International | false | false |
| 25 | 23 | In the Loop | $37,375 | -30.8% | 14 | -8 | $2,669 | $510,215 | 5 | N/A | false | false |
| 26 | 22 | Blame It on Mum | $32,458 | -47.9% | 18 | -9 | $1,803 | $210,510 | 3 | Golem Distribución | false | false |
| 27 | 25 | Garbo: The Spy | $31,404 | +8.6% | 6 | - | $5,234 | $193,915 | 5 | N/A | false | false |
| 28 | 17 | What Just Happened | $28,428 | -82.7% | 27 | -58 | $1,052 | $1,281,684 | 4 | Filmax | false | false |
