| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Alvin and the Chipmunks: The Squeakquel | $3,397,197 | - | 395 | - | $8,600 | $5,085,007 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Avatar | $3,150,762 | -21.8% | 613 | -21 | $5,139 | $27,787,826 | 4 | 20th Century Fox International | false | false |
| 3 | - | Sherlock Holmes | $2,329,120 | - | 342 | - | $6,810 | $2,329,120 | 1 | Warner Bros. | true | false |
| 4 | 2 | Lula, the Son of Brazil | $560,867 | -51.4% | 346 | -4 | $1,621 | $2,411,872 | 2 | Europa Filmes | false | false |
| 5 | 3 | Couples Retreat | $355,967 | -46.7% | 160 | -11 | $2,224 | $2,883,461 | 3 | Universal Pictures International (UPI) | false | false |
| 6 | 4 | Hachi: A Dog's Tale | $317,754 | -51.9% | 151 | -30 | $2,104 | $2,803,340 | 3 | N/A | false | false |
| 7 | 5 | Xuxa and the Mystery of the Little Ugly Princess | $315,305 | -28.1% | 206 | -16 | $1,530 | $2,430,054 | 3 | PlayArte Pictures | false | false |
| 8 | 6 | The Twilight Saga: New Moon | $132,784 | -59.7% | 136 | -161 | $976 | $26,784,533 | 8 | Paris Filmes | false | false |
| 9 | 8 | The Fourth Kind | $124,306 | -52.8% | 65 | +2 | $1,912 | $580,322 | 2 | N/A | false | false |
| 10 | 7 | 2012 | $124,055 | -61.6% | 108 | -121 | $1,148 | $25,345,430 | 9 | Sony Pictures Releasing | false | false |
| 11 | 9 | The Princess and the Frog | $93,082 | -52.8% | 164 | -13 | $567 | $3,577,317 | 5 | Walt Disney Pictures | false | false |
| 12 | 12 | Broken Embraces | $40,211 | -17.3% | 24 | +3 | $1,675 | $1,234,221 | 6 | Universal Pictures International (UPI) | false | false |
| 13 | 11 | New York, I Love You | $32,494 | -47.1% | 12 | -1 | $2,707 | $381,039 | 4 | N/A | false | false |
| 14 | 10 | Paranormal Activity | $24,791 | -78.9% | 53 | -58 | $467 | $5,100,263 | 6 | PlayArte Pictures | false | false |
| 15 | - | Easy Virtue | $19,417 | - | 3 | - | $6,472 | $106,787 | 12 | Sony Pictures Releasing | false | false |
| 16 | - | The Edge of Love | $16,883 | - | 8 | - | $2,110 | $16,883 | 1 | N/A | true | false |
| 17 | 13 | Inglourious Basterds | $11,790 | -17.7% | 11 | +1 | $1,071 | $5,003,897 | 14 | Universal Pictures International (UPI) | false | false |
| 18 | 15 | Julie & Julia | $9,747 | -24.3% | 13 | -3 | $749 | $1,079,640 | 7 | Sony Pictures Releasing | false | false |
| 19 | 17 | 500 Days of Summer | $8,365 | -23.8% | 9 | -8 | $929 | $1,228,846 | 10 | 20th Century Fox International | false | false |
| 20 | 18 | Coco Before Chanel | $6,637 | -26% | 7 | +1 | $948 | $819,740 | 11 | Warner Bros. | false | false |
| 21 | 16 | Planet 51 | $5,696 | -55.7% | 44 | -12 | $129 | $2,186,036 | 7 | N/A | false | false |
| 22 | 20 | Smoke Gets in Your Eyes | $5,216 | -27.8% | 10 | +1 | $521 | $188,730 | 6 | PlayArte Pictures | false | false |
| 23 | 22 | Law Abiding Citizen | $3,115 | -3.1% | 2 | -6 | $1,557 | $2,037,344 | 10 | N/A | false | false |
| 24 | 21 | A Christmas Carol | $2,227 | -48.4% | 13 | -5 | $171 | $3,085,214 | 10 | Walt Disney Pictures | false | false |
| 25 | 28 | Saw VI | $1,351 | +7.1% | 5 | -2 | $270 | $1,829,872 | 10 | Walt Disney Pictures | false | false |
| 26 | 26 | The Soloist | $1,189 | -27.7% | 6 | -2 | $198 | $250,949 | 10 | Universal Pictures International (UPI) | false | false |
| 27 | 24 | The Private Lives of Pippa Lee | $958 | -57.5% | 6 | - | $159 | $67,240 | 4 | PlayArte Pictures | false | false |
| 28 | 23 | Cloudy with a Chance of Meatballs | $911 | -61.9% | 8 | -11 | $113 | $7,798,050 | 15 | Sony Pictures Releasing | false | false |
| 29 | 25 | Fantastic Mr. Fox | $864 | -54% | 8 | +6 | $108 | $42,645 | 6 | 20th Century Fox International | false | false |
| 30 | 27 | Surrogates | $257 | -82% | 3 | -1 | $85 | $1,838,308 | 12 | Walt Disney Pictures | false | false |
| 31 | - | Soul Power | $228 | - | 1 | - | $228 | $4,671 | 4 | Sony Pictures Releasing | false | false |
| 32 | 31 | The Assailant | $79 | +25.4% | 3 | +1 | $26 | $2,134,974 | 11 | Walt Disney Pictures | false | false |
| 33 | - | Up | $76 | - | 1 | - | $76 | $11,154,142 | 19 | Walt Disney Pictures | false | false |
