| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | The Blind Side | $20,440,000 | $20,043,181 | -$396,819 | -1.9% | 3,326 | $129,264,000 | $128,867,559 | 3 | Warner Bros. | - |
| 2 | 2 | - | The Twilight Saga: New Moon | $15,704,000 | $15,427,628 | -$276,372 | -1.8% | 4,124 | $255,639,000 | $255,363,052 | 3 | Summit Entertainment | - |
| 3 | 3 | - | Brothers | $9,700,000 | $9,527,848 | -$172,152 | -1.8% | 2,088 | $9,700,000 | $9,527,848 | 1 | Lionsgate | - |
| 4 | 4 | - | A Christmas Carol | $7,520,000 | $7,763,244 | +$243,244 | +3.2% | 2,546 | $115,006,000 | $115,249,331 | 5 | Walt Disney Studios Motion Pictures | - |
| 5 | 5 | - | Old Dogs | $6,901,000 | $6,892,265 | -$8,735 | -0.1% | 3,425 | $33,934,000 | $33,924,385 | 2 | Walt Disney Studios Motion Pictures | - |
| 6 | 6 | - | 2012 | $6,600,000 | $6,771,665 | +$171,665 | +2.6% | 3,220 | $148,787,000 | $148,958,486 | 4 | Sony Pictures Releasing | - |
| 7 | 7 | - | Armored | $6,600,000 | $6,511,128 | -$88,872 | -1.3% | 1,915 | $6,600,000 | $6,511,128 | 1 | Screen Gems | - |
| 8 | 8 | - | Ninja Assassin | $5,030,000 | $5,061,499 | +$31,499 | +0.6% | 2,503 | $29,790,000 | $29,821,996 | 2 | Warner Bros. | - |
| 9 | 9 | - | Planet 51 | $4,300,000 | $4,386,873 | +$86,873 | +2% | 2,904 | $33,966,000 | $34,052,876 | 3 | Sony Pictures Releasing | - |
| 10 | 10 | - | Everybody's Fine | $4,027,000 | $3,852,068 | -$174,932 | -4.3% | 2,133 | $4,027,000 | $3,852,068 | 1 | Miramax | - |
| 11 | 11 | - | Fantastic Mr. Fox | $2,885,000 | $2,918,331 | +$33,331 | +1.2% | 2,034 | $14,051,000 | $14,084,495 | 4 | Twentieth Century Fox | - |
| 12 | 12 | - | Precious | $2,310,000 | $2,282,077 | -$27,923 | -1.2% | 664 | $36,280,000 | $36,252,012 | 5 | Lionsgate | - |
| 13 | 13 | - | Up in the Air | $1,160,000 | $1,181,450 | +$21,450 | +1.8% | 15 | $1,160,000 | $1,181,450 | 1 | Paramount Pictures | - |
| 14 | 14 | - | The Boondock Saints II: All Saints Day | $950,000 | $922,623 | -$27,377 | -2.9% | 432 | $7,245,000 | $7,218,197 | 6 | Apparition | - |
| 15 | 15 | - | The Road | $760,000 | $749,535 | -$10,465 | -1.4% | 128 | $3,205,000 | $3,194,349 | 2 | Dimension Films | - |
| 16 | 16 | - | The Princess and the Frog | $744,000 | $747,710 | +$3,710 | +0.5% | 2 | $2,407,000 | $2,410,810 | 2 | Walt Disney Studios Motion Pictures | - |
| 17 | 17 | - | An Education | $483,000 | $479,774 | -$3,226 | -0.7% | 236 | $6,268,000 | $6,264,756 | 9 | Sony Pictures Classics | - |
| 18 | 18 | - | The Men Who Stare at Goats | $401,000 | $400,153 | -$847 | -0.2% | 509 | $31,290,000 | $31,289,229 | 5 | Overture Films | - |
| 19 | 19 | - | The Boat That Rocked | $335,000 | $333,475 | -$1,525 | -0.5% | 285 | $7,385,000 | $7,383,803 | 4 | Focus Features | - |
| 20 | 20 | - | Couples Retreat | $315,000 | $313,005 | -$1,995 | -0.6% | 432 | $107,236,000 | $107,233,200 | 9 | Universal Pictures | - |
| 21 | 21 | - | Transylmania | $252,000 | $263,941 | +$11,941 | +4.7% | 1,007 | $252,000 | $263,941 | 1 | Full Circle Releasing | - |
| 22 | 22 | - | Law Abiding Citizen | $250,000 | $253,146 | +$3,146 | +1.3% | 316 | $71,988,000 | $71,991,438 | 8 | Overture Films | - |
| 23 | 23 | - | A Serious Man | $215,000 | $221,428 | +$6,428 | +3% | 160 | $8,488,000 | $8,488,738 | 10 | Focus Features | - |
| 24 | 25 | +1 | The Fourth Kind | $180,000 | $187,050 | +$7,050 | +3.9% | 243 | $24,935,000 | $24,941,980 | 5 | Universal Pictures | - |
| 25 | 27 | +2 | Bad Lieutenant: Port of Call New Orleans | $153,000 | $150,205 | -$2,795 | -1.8% | 71 | $943,000 | $940,824 | 3 | First Look International | - |
| 26 | 29 | +3 | Paranormal Activity | $115,000 | $122,055 | +$7,055 | +6.1% | 308 | $107,370,000 | $107,377,206 | 11 | Paramount Pictures | - |
| 27 | 31 | +4 | Broken Embraces | $90,300 | $88,570 | -$1,730 | -1.9% | 2 | $455,000 | $452,878 | 3 | Sony Pictures Classics | - |
| 28 | 34 | +6 | The Messenger | $80,500 | $71,515 | -$8,985 | -11.2% | 50 | $474,000 | $464,878 | 4 | Oscilloscope | - |
| 29 | 33 | +4 | Coco Before Chanel | $80,300 | $81,193 | +$893 | +1.1% | 103 | $5,795,000 | $5,795,589 | 11 | Sony Pictures Classics | - |
| 30 | 36 | +6 | Inglourious Basterds | $65,000 | $62,924 | -$2,076 | -3.2% | 194 | $120,467,000 | $120,464,449 | 16 | The Weinstein Company | - |
| 31 | 37 | +6 | Astro Boy | $55,000 | $57,989 | +$2,989 | +5.4% | 158 | $19,012,000 | $19,014,667 | 7 | Summit Entertainment | - |
| 32 | 42 | +10 | Me and Orson Welles | $40,700 | $39,587 | -$1,113 | -2.7% | 5 | $150,000 | $149,051 | 2 | Freestyle Releasing | - |
| 33 | 44 | +11 | La Danse: The Paris Opera Ballet | $36,900 | $34,425 | -$2,475 | -6.7% | 16 | $233,000 | $230,287 | 5 | Zipporah Films | - |
| 34 | 45 | +11 | The Private Lives of Pippa Lee | $31,000 | $32,071 | +$1,071 | +3.5% | 13 | $146,000 | $146,846 | 2 | Screen Media Films | - |
| 35 | 64 | +29 | Fame | $12,000 | $10,597 | -$1,403 | -11.7% | 62 | $22,454,000 | $22,452,209 | 11 | Metro-Goldwyn-Mayer (MGM) | - |
| 36 | 61 | +25 | New York, I Love You | $11,000 | $11,735 | +$735 | +6.7% | 14 | $1,545,000 | $1,546,139 | 8 | Vivendi Entertainment | - |
