| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | This Is It | $258,573 | -44.9% | 81 | - | $3,192 | $877,943 | 2 | N/A | false | false |
| 2 | - | Law Abiding Citizen | $135,163 | - | 51 | - | $2,650 | $135,163 | 1 | N/A | true | false |
| 3 | - | A Christmas Carol | $104,916 | - | 76 | - | $1,380 | $104,916 | 1 | N/A | true | false |
| 4 | 2 | The Ugly Truth | $81,719 | -1.8% | 54 | - | $1,513 | $960,149 | 5 | N/A | false | false |
| 5 | 3 | Inglourious Basterds | $65,877 | -19.4% | 59 | - | $1,116 | $407,061 | 3 | N/A | false | false |
| 6 | 4 | Cloudy with a Chance of Meatballs | $61,962 | -21.4% | 56 | -13 | $1,106 | $449,791 | 4 | N/A | false | false |
| 7 | 6 | Gamer | $23,330 | -34.9% | 31 | -4 | $752 | $160,082 | 3 | N/A | false | false |
| 8 | 5 | Up | $22,288 | -40.3% | 32 | -27 | $696 | $1,907,179 | 9 | Ster-Kinekor Pictures | false | false |
| 9 | 8 | Jennifer's Body | $19,287 | -24.8% | 23 | -2 | $838 | $165,207 | 4 | N/A | false | false |
| 10 | 9 | The Taking of Pelham 123 | $16,841 | -32% | 29 | -17 | $580 | $821,506 | 7 | N/A | false | false |
| 11 | 7 | The Final Destination | $16,168 | -48.1% | 21 | -12 | $769 | $539,231 | 6 | N/A | false | false |
| 12 | 10 | Imagine That | $15,045 | -24.1% | 28 | -3 | $537 | $472,952 | 7 | N/A | false | false |
| 13 | 13 | Whatever Works | $11,165 | -8.2% | 11 | - | $1,015 | $31,129 | 2 | N/A | false | false |
| 14 | 15 | Last Chance Harvey | $11,015 | -2% | 13 | - | $847 | $204,447 | 6 | N/A | false | false |
| 15 | 12 | Aliens in the Attic | $9,815 | -21.1% | 16 | -1 | $613 | $169,036 | 6 | N/A | false | false |
| 16 | 14 | Pandorum | $8,359 | -31.2% | 15 | - | $557 | $28,415 | 2 | N/A | false | false |
| 17 | - | Fireflies in the Garden | $7,723 | - | 10 | - | $772 | $7,723 | 1 | N/A | true | false |
| 18 | 11 | Fame | $5,945 | -55.8% | 18 | -14 | $330 | $609,928 | 7 | N/A | false | false |
| 19 | 18 | Blood: The Last Vampire | $5,581 | -21.5% | 12 | -1 | $465 | $110,392 | 5 | N/A | false | false |
| 20 | 19 | Dance Flick | $1,169 | -36.6% | 5 | -1 | $233 | $75,790 | 9 | United International Pictures | false | false |
| 21 | 21 | Public Enemies | $200 | -48.5% | 2 | -1 | $100 | $452,624 | 10 | United International Pictures | false | false |
| 22 | 23 | Looking for Eric | $199 | +44.2% | 2 | +1 | $99 | $24,643 | 5 | N/A | false | false |
