| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | A Christmas Carol | $866,798 | - | 120 | - | $7,223 | $866,798 | 1 | Walt Disney Pictures | true | false |
| 2 | - | Saw VI | $740,423 | - | 204 | - | $3,629 | $740,423 | 1 | Walt Disney Pictures | true | false |
| 3 | - | Law Abiding Citizen | $642,684 | - | 135 | - | $4,760 | $642,684 | 1 | N/A | true | false |
| 4 | 1 | This Is It | $599,704 | -45.3% | 201 | -1 | $2,983 | $2,758,057 | 2 | Sony Pictures Releasing | false | false |
| 5 | 3 | The Assailant | $348,266 | -28.7% | 138 | -7 | $2,523 | $1,271,785 | 2 | Walt Disney Pictures | false | false |
| 6 | - | Inglourious Basterds | $256,308 | - | 165 | - | $1,553 | $4,405,247 | 5 | Universal Pictures International (UPI) | false | false |
| 7 | - | 500 Days of Summer | $207,066 | - | 39 | - | $5,309 | $207,066 | 1 | 20th Century Fox International | true | false |
| 8 | 4 | Surrogates | $190,424 | -49.1% | 86 | -18 | $2,214 | $1,513,222 | 3 | Walt Disney Pictures | false | false |
| 9 | 2 | Cloudy with a Chance of Meatballs | $173,704 | -65.7% | 172 | -58 | $1,009 | $7,388,034 | 6 | Sony Pictures Releasing | false | false |
| 10 | 5 | The Ugly Truth | $169,426 | -38.5% | 140 | -13 | $1,210 | $7,070,949 | 8 | Sony Pictures Releasing | false | false |
| 11 | - | The Hangover | $119,095 | - | 111 | - | $1,072 | $8,716,977 | 12 | Warner Bros. | false | false |
| 12 | - | Coco Before Chanel | $112,511 | - | 18 | - | $6,250 | $390,255 | 2 | Warner Bros. | false | false |
| 13 | - | Fame | $109,266 | - | 90 | - | $1,214 | $109,266 | 1 | PlayArte Pictures | true | false |
| 14 | 6 | District 9 | $97,312 | -63.9% | 131 | -53 | $742 | $2,524,054 | 4 | Sony Pictures Releasing | false | false |
| 15 | - | Vampire Killers | $90,382 | - | 114 | - | $792 | $548,299 | 2 | N/A | false | false |
| 16 | - | The Soloist | $65,887 | - | 25 | - | $2,635 | $65,887 | 1 | Universal Pictures International (UPI) | true | false |
| 17 | 7 | Up | $51,667 | -53% | 138 | -69 | $374 | $10,893,058 | 10 | Walt Disney Pictures | false | false |
| 18 | - | The Time Traveler's Wife | $50,068 | - | 20 | - | $2,503 | $1,355,724 | 4 | PlayArte Pictures | false | false |
| 19 | - | The Rebound | $49,685 | - | 44 | - | $1,129 | $917,336 | 4 | N/A | false | false |
| 20 | - | Jennifer's Body | $32,641 | - | 43 | - | $759 | $313,879 | 3 | 20th Century Fox International | false | false |
| 21 | 8 | Time of Fear | $18,414 | -38.2% | 50 | -36 | $368 | $1,448,317 | 6 | Sony Pictures Releasing | false | false |
| 22 | - | Alô, Alô, Terezinha! | $16,980 | - | 47 | - | $361 | $95,402 | 2 | N/A | false | false |
| 23 | - | The Informant! | $16,607 | - | 22 | - | $754 | $437,728 | 4 | Warner Bros. | false | false |
| 24 | - | Spread | $13,031 | - | 24 | - | $542 | $558,301 | 7 | N/A | false | false |
| 25 | - | The Dolphin: Story of a Dreamer | $10,331 | - | 45 | - | $229 | $250,000 | 5 | 20th Century Fox International | false | false |
| 26 | 10 | Easy Virtue | $9,563 | -41.5% | 4 | +1 | $2,390 | $69,757 | 3 | Sony Pictures Releasing | false | false |
| 27 | - | So Normal 2: The Craziest Night Ever | $9,009 | - | 30 | - | $300 | $10,695,108 | 11 | N/A | false | false |
| 28 | 9 | The Taking of Pelham 123 | $4,893 | -74.4% | 32 | -21 | $152 | $4,241,557 | 10 | Sony Pictures Releasing | false | false |
| 29 | - | The Brothers Bloom | $3,311 | - | 11 | - | $301 | $178,400 | 3 | Paris Filmes | false | false |
| 30 | 11 | G-Force | $569 | -67.6% | 8 | -9 | $71 | $4,409,348 | 13 | Walt Disney Pictures | false | false |
