| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Up | $10,156,720 | - | 511 | - | $19,876 | $10,156,720 | - | Walt Disney Pictures | - | false |
| 2 | - | Zombieland | $1,965,791 | - | 298 | - | $6,596 | $1,965,791 | - | Sony Pictures Releasing | - | false |
| 3 | 2 | The Invention of Lying | $1,716,726 | -37.9% | 369 | +1 | $4,652 | $5,993,730 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 1 | Fame | $1,436,546 | -49.6% | 448 | -12 | $3,206 | $11,173,917 | 3 | Entertainment Film Distributors | false | false |
| 5 | - | Love Happens | $886,635 | - | 362 | - | $2,449 | $886,635 | 1 | Entertainment One | true | false |
| 6 | - | Halloween II | $827,925 | - | 286 | - | $2,894 | $827,925 | 1 | Entertainment Film Distributors | true | false |
| 7 | 4 | Cloudy with a Chance of Meatballs | $569,732 | -68.2% | 411 | +10 | $1,386 | $8,570,424 | 4 | Sony Pictures Releasing | false | false |
| 8 | 5 | Surrogates | $514,469 | -45.5% | 336 | -24 | $1,531 | $4,377,712 | 3 | Walt Disney Pictures | false | false |
| 9 | 6 | District 9 | $339,616 | -47.4% | 251 | -101 | $1,353 | $13,774,631 | 6 | Sony Pictures Releasing | false | false |
| 10 | 8 | 500 Days of Summer | $199,214 | -49.3% | 192 | -97 | $1,037 | $7,596,857 | 6 | 20th Century Fox International | false | false |
| 11 | 7 | Pandorum | $162,843 | -70.5% | 263 | -48 | $619 | $1,032,492 | 5 | Icon Film Distribution | false | false |
| 12 | 12 | Julie & Julia | $107,192 | -48.4% | 122 | -68 | $878 | $3,996,292 | 5 | Sony Pictures Releasing | false | false |
| 13 | 9 | The Soloist | $102,592 | -69.2% | 136 | -196 | $754 | $1,679,198 | 5 | Universal Pictures International (UPI) | false | false |
| 14 | 15 | Wake Up Sid | $101,847 | -37.3% | 35 | -9 | $2,909 | $337,281 | 2 | UTV Motion Pictures | false | false |
| 15 | 11 | Dorian Gray | $97,152 | -56.3% | 102 | -123 | $952 | $4,466,510 | 5 | Momentum Pictures | false | false |
| 16 | 13 | Creation | $76,748 | -60.2% | 75 | -116 | $1,023 | $1,015,814 | 3 | Icon Film Distribution | false | false |
