| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Inglourious Basterds | $45,855 | - | 8 | - | $5,731 | $45,855 | 1 | United International Pictures | true | false |
| 2 | 1 | Surrogates | $20,295 | -41.1% | 6 | - | $3,382 | $59,692 | 2 | Walt Disney Pictures | false | false |
| 3 | 2 | The Ugly Truth | $19,337 | -14.3% | 6 | - | $3,222 | $138,220 | 4 | Sony Pictures Releasing | false | false |
| 4 | 3 | The Final Destination | $15,317 | -27.4% | 5 | - | $3,063 | $191,493 | 5 | Warner Bros. | false | false |
| 5 | 4 | Orphan | $12,952 | -12.7% | 5 | - | $2,590 | $59,714 | 3 | Warner Bros. | false | false |
| 6 | - | I Hate Valentine's Day | $10,611 | - | 3 | - | $3,537 | $10,611 | 1 | United Motion Pictures | true | false |
| 7 | 6 | Red Cliff | $7,438 | -26.3% | 5 | - | $1,487 | $19,588 | 2 | United Motion Pictures | false | false |
| 8 | 5 | Jennifer's Body | $7,410 | -35.2% | 3 | - | $2,470 | $20,936 | 2 | 20th Century Fox International | false | false |
| 9 | 8 | Land of the Lost | $4,547 | -24.9% | 6 | - | $757 | $27,060 | 3 | United International Pictures | false | false |
| 10 | 7 | G.I. Joe: The Rise of Cobra | $4,527 | -48.6% | 8 | - | $565 | $95,573 | 4 | United International Pictures | false | false |
| 11 | - | Blood: The Last Vampire | $3,421 | - | 3 | - | $1,140 | $3,421 | 1 | N/A | true | false |
| 12 | 9 | Gamer | $2,587 | -45.3% | 3 | -1 | $862 | $69,650 | 5 | United Motion Pictures | false | false |
| 13 | 10 | The Other Man | $2,511 | -44.6% | 4 | - | $627 | $20,139 | 3 | N/A | false | false |
| 14 | - | The Flight Before Christmas | $1,756 | - | 2 | - | $878 | $1,756 | 1 | United Motion Pictures | true | false |
| 15 | 12 | The Hangover | $1,035 | -59.2% | 1 | -1 | $1,035 | $182,121 | 12 | Warner Bros. | false | false |
| 16 | 11 | Cloudy with a Chance of Meatballs | $969 | -76.5% | 2 | - | $484 | $36,005 | 5 | Sony Pictures Releasing | false | false |
| 17 | 14 | Imagine That | $562 | +19.8% | 2 | - | $281 | $63,400 | 11 | United International Pictures | false | false |
| 18 | 15 | Slaughter | $113 | -8.1% | 1 | - | $113 | $20,957 | 6 | N/A | false | false |
| 19 | 13 | Aliens in the Attic | $32 | -98.3% | 1 | -2 | $32 | $9,344 | 3 | 20th Century Fox International | false | false |
