| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Inglourious Basterds | $930,042 | - | 179 | - | $5,195 | $930,042 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 2 | The Ugly Truth | $683,447 | -14.1% | 164 | - | $4,167 | $4,559,210 | 4 | Sony Pictures Releasing | false | false |
| 3 | 4 | The Hangover | $393,272 | -14.1% | 180 | -2 | $2,184 | $7,080,612 | 8 | Warner Bros. | false | false |
| 4 | 3 | Up | $337,758 | -28.5% | 254 | +4 | $1,329 | $9,612,993 | 6 | Walt Disney Pictures | false | false |
| 5 | 5 | So Normal 2: The Craziest Night Ever | $292,312 | -32.9% | 301 | -53 | $971 | $9,854,433 | 7 | N/A | false | false |
| 6 | 6 | Time of Fear | $249,757 | -39.9% | 171 | -15 | $1,460 | $832,564 | 2 | Sony Pictures Releasing | false | false |
| 7 | - | 9 | $200,839 | - | 141 | - | $1,424 | $200,839 | 1 | PlayArte Pictures | true | false |
| 8 | 8 | The Taking of Pelham 123 | $124,069 | -45% | 154 | -20 | $805 | $3,931,375 | 6 | Sony Pictures Releasing | false | false |
| 9 | 7 | Gamer | $111,984 | -56% | 93 | -9 | $1,204 | $471,633 | 2 | N/A | false | false |
| 10 | - | The Dolphin: Story of a Dreamer | $59,605 | - | 64 | - | $931 | $59,605 | 1 | 20th Century Fox International | true | false |
| 11 | 9 | Whiteout | $54,383 | -54.7% | 49 | - | $1,109 | $222,209 | 2 | Warner Bros. | false | false |
| 12 | 12 | My Sister's Keeper | $50,436 | -39.5% | 77 | -13 | $655 | $1,083,606 | 5 | PlayArte Pictures | false | false |
| 13 | - | Herbert de Perto | $44,692 | - | 31 | - | $1,441 | $44,692 | 1 | N/A | true | false |
| 14 | 1 | Cloudy with a Chance of Meatballs | $43,704 | -96.7% | 2 | -248 | $21,852 | $102,750 | 2 | Sony Pictures Releasing | false | false |
| 15 | 11 | Aliens in the Attic | $40,420 | -51.5% | 82 | -2 | $492 | $384,772 | 3 | 20th Century Fox International | false | false |
| 16 | 10 | Spread | $29,958 | -69.4% | 34 | -14 | $881 | $365,628 | 3 | N/A | false | false |
| 17 | 16 | G-Force | $25,460 | -20.7% | 145 | -15 | $175 | $4,309,807 | 9 | Walt Disney Pictures | false | false |
| 18 | 14 | Orphan | $24,478 | -47.2% | 52 | -8 | $470 | $777,057 | 6 | Warner Bros. | false | false |
| 19 | 15 | Two Lovers | $23,297 | -34% | 26 | -6 | $896 | $641,408 | 7 | PlayArte Pictures | false | false |
| 20 | 31 | Che: Part Two | $16,904 | +654% | 24 | +18 | $704 | $84,575 | 4 | Europa Filmes | false | false |
| 21 | 23 | Shorts | $11,076 | +179.6% | 42 | +12 | $263 | $265,021 | 7 | Warner Bros. | false | false |
| 22 | 13 | Sorority Row | $10,009 | -82.3% | 32 | -42 | $312 | $285,857 | 3 | Paris Filmes | false | false |
| 23 | 17 | My Life in Ruins | $8,932 | -68.6% | 51 | -18 | $175 | $798,337 | 5 | N/A | false | false |
| 24 | 22 | Ice Age: Dawn of the Dinosaurs | $6,505 | +36.7% | 64 | -11 | $101 | $45,355,782 | 15 | 20th Century Fox International | false | false |
| 25 | 18 | The Proposal | $3,290 | -61.4% | 7 | -7 | $470 | $7,338,091 | 14 | Walt Disney Pictures | false | false |
| 26 | 25 | Bandslam | $2,693 | -23.6% | 26 | -6 | $103 | $140,594 | 5 | Paris Filmes | false | false |
| 27 | 20 | Drag Me to Hell | $2,032 | -68.6% | 10 | -18 | $203 | $1,790,906 | 9 | Universal Pictures International (UPI) | false | false |
| 28 | 28 | The Invisible Woman | $1,321 | -45.2% | 4 | -6 | $330 | $11,436,322 | 19 | Warner Bros. | false | false |
| 29 | 24 | Adrift | $1,297 | -65.4% | 11 | -8 | $117 | $471,448 | 11 | Universal Pictures International (UPI) | false | false |
| 30 | 21 | Brüno | $1,067 | -81.8% | 7 | -7 | $152 | $1,167,629 | 9 | Sony Pictures Releasing | false | false |
| 31 | 29 | Time of Peace | $808 | -66.3% | 13 | -8 | $62 | $428,328 | 9 | N/A | false | false |
| 32 | 32 | The International | $88 | -80% | 3 | -2 | $29 | $625,835 | 17 | Sony Pictures Releasing | false | false |
