| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Ugly Truth | $8,729 | -19.4% | 6 | - | $1,454 | $60,653 | 3 | Sony Pictures Releasing | false | false |
| 2 | - | G.I. Joe: The Rise of Cobra | $8,301 | - | 6 | - | $1,383 | $9,956 | 1 | United International Pictures | true | false |
| 3 | 2 | Up | $7,522 | -17.7% | 6 | - | $1,253 | $28,323 | 2 | Walt Disney Pictures | false | false |
| 4 | 4 | Ice Age: Dawn of the Dinosaurs | $7,195 | -9.2% | 9 | - | $799 | $398,607 | 13 | 20th Century Fox International | false | false |
| 5 | 5 | Inglourious Basterds | $7,101 | +6.3% | 6 | - | $1,183 | $162,205 | 6 | United International Pictures | false | false |
| 6 | 3 | The Final Destination | $6,794 | -22.9% | 4 | - | $1,698 | $21,988 | 2 | Warner Bros. | false | false |
| 7 | - | The Brothers Bloom | $3,747 | - | 3 | - | $1,249 | $4,359 | 1 | N/A | true | false |
| 8 | 6 | Harry Potter and the Half-Blood Prince | $2,033 | -40% | 8 | - | $254 | $194,363 | 11 | Warner Bros. | false | false |
| 9 | 7 | The Taking of Pelham 123 | $2,006 | -5.1% | 5 | - | $401 | $34,147 | 5 | Sony Pictures Releasing | false | false |
| 10 | - | The True Story of Puss'N Boots | $1,098 | - | 4 | - | $274 | $1,280 | 1 | N/A | true | false |
| 11 | 8 | G-Force | $840 | -47.3% | 5 | - | $168 | $26,485 | 5 | Walt Disney Pictures | false | false |
| 12 | 11 | The Hangover | $594 | +29.1% | 5 | - | $118 | $142,755 | 15 | Warner Bros. | false | false |
| 13 | 12 | Coraline | $292 | -29.5% | 4 | - | $73 | $35,339 | 17 | United International Pictures | false | false |
| 14 | 9 | The Proposal | $258 | -81.8% | 6 | - | $43 | $106,248 | 10 | Walt Disney Pictures | false | false |
| 15 | 16 | Knowing | $161 | +3.2% | 4 | - | $40 | $27,189 | 9 | N/A | false | false |
| 16 | - | Ghosts of Girlfriends Past | $87 | - | 5 | - | $17 | $59,083 | 16 | Warner Bros. | false | false |
| 17 | 13 | Two Lovers | $81 | -67.7% | 3 | - | $27 | $12,158 | 5 | N/A | false | false |
| 18 | 10 | Public Enemies | $59 | -88.2% | 5 | - | $11 | $76,650 | 13 | United International Pictures | false | false |
| 19 | 15 | Superhero Movie | $59 | -67.8% | 1 | - | $59 | $2,876 | 4 | N/A | false | false |
| 20 | 19 | Brüno | $55 | +77.4% | 6 | - | $9 | $64,691 | 12 | N/A | false | false |
| 21 | - | Hotel for Dogs | $16 | - | 6 | - | $2 | $33,629 | 23 | United International Pictures | false | false |
| 22 | 14 | Hannah Montana: The Movie | $9 | -96.2% | 5 | - | $1 | $32,829 | 16 | Walt Disney Pictures | false | false |
