| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Surrogates | $509,402 | - | 36 | - | $14,150 | $509,402 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | The Final Destination | $260,683 | -65.4% | 47 | -12 | $5,546 | $1,251,000 | 2 | Warner Bros. | false | false |
| 3 | - | The Time Traveler's Wife | $219,730 | - | 22 | - | $9,987 | $219,730 | 1 | Lark Films Distribution | true | false |
| 4 | 2 | The Proposal | $179,574 | -49.2% | 30 | -4 | $5,985 | $1,434,367 | 3 | Walt Disney Pictures | false | false |
| 5 | 3 | Accident | $123,031 | -64.2% | 42 | -2 | $2,929 | $591,546 | 2 | Newport Entertainment | false | false |
| 6 | 4 | Tidal Wave | $92,927 | -62.7% | 35 | -1 | $2,655 | $428,277 | 2 | Edko Films | false | false |
| 7 | 5 | Brüno | $14,651 | -67.1% | 6 | -3 | $2,441 | $209,201 | 3 | Panasia Films | false | false |
| 8 | 6 | My Sister's Keeper | $11,610 | -52.3% | 4 | - | $2,902 | $164,819 | 4 | Warner Bros. | false | false |
| 9 | - | Bandslam | $10,100 | - | 8 | - | $1,262 | $10,100 | 1 | Deltamac Co. | true | false |
| 10 | 9 | Inglourious Basterds | $8,454 | -13.8% | 4 | -1 | $2,113 | $769,486 | 6 | Edko Films | false | false |
| 11 | 10 | Up | $4,937 | -47.9% | 2 | -2 | $2,468 | $4,321,292 | 9 | Walt Disney Pictures | false | false |
| 12 | 7 | Orphan | $4,686 | -72.4% | 2 | -11 | $2,343 | $1,067,294 | 5 | Warner Bros. | false | false |
| 13 | - | Lorna's Silence | $4,102 | - | 2 | - | $2,051 | $4,102 | 1 | N/A | true | false |
| 14 | - | Glamorous Youth | $3,516 | - | 1 | - | $3,516 | $3,516 | 1 | N/A | true | false |
| 15 | 11 | Ai Chu Mao | $2,034 | -75.4% | 3 | -1 | $678 | $244,538 | 4 | N/A | false | false |
| 16 | 20 | Welcome to the Sticks | $1,170 | -14% | 1 | - | $1,170 | $9,384 | 3 | Edko Films | false | false |
| 17 | 15 | The Limits of Control | $977 | -75% | 1 | - | $977 | $6,934 | 2 | Golden Scene | false | false |
| 18 | 16 | More Than Blue | $924 | -72.3% | 1 | -4 | $924 | $77,685 | 4 | Intercontinental Film Distributors (HK) | false | false |
| 19 | 8 | The Taking of Pelham 123 | $862 | -94% | 4 | -12 | $215 | $584,112 | 4 | Sony Pictures Releasing | false | false |
| 20 | 19 | G-Force | $776 | -68% | 1 | - | $776 | $1,262,002 | 6 | Walt Disney Pictures | false | false |
| 21 | 23 | Turning Point | $321 | -73.3% | 1 | -3 | $321 | $2,020,712 | 7 | Intercontinental Film Distributors (HK) | false | false |
| 22 | 21 | The Hangover | $285 | -78.6% | 2 | +1 | $142 | $720,509 | 9 | Warner Bros. | false | false |
| 23 | 12 | My Life in Ruins | $121 | -98.5% | 1 | -8 | $121 | $127,099 | 4 | Lark Films Distribution | false | false |
