| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $889,293 | -25% | 318 | -4 | $2,796 | $7,815,984 | 4 | Walt Disney Pictures | false | false |
| 2 | 2 | The Ugly Truth | $799,907 | -27.3% | 164 | +1 | $4,877 | $2,452,305 | 2 | Sony Pictures Releasing | false | false |
| 3 | 3 | So Normal 2: The Craziest Night Ever | $520,562 | -25.7% | 379 | -13 | $1,373 | $8,112,600 | 5 | N/A | false | false |
| 4 | 4 | The Hangover | $439,730 | -12.5% | 184 | +3 | $2,389 | $5,473,251 | 6 | Warner Bros. | false | false |
| 5 | 5 | The Taking of Pelham 123 | $320,525 | -30.2% | 181 | - | $1,770 | $3,335,097 | 4 | Sony Pictures Releasing | false | false |
| 6 | - | Aliens in the Attic | $178,165 | - | 83 | - | $2,146 | $178,165 | 1 | 20th Century Fox International | true | false |
| 7 | - | Spread | $141,186 | - | 52 | - | $2,715 | $141,186 | 1 | N/A | true | false |
| 8 | 6 | My Sister's Keeper | $125,399 | -29.6% | 94 | - | $1,334 | $802,343 | 3 | PlayArte Pictures | false | false |
| 9 | - | Sorority Row | $122,812 | - | 80 | - | $1,535 | $122,812 | 1 | Paris Filmes | true | false |
| 10 | 7 | My Life in Ruins | $70,839 | -49.4% | 112 | -7 | $632 | $661,916 | 3 | N/A | false | false |
| 11 | 9 | Orphan | $55,419 | -21% | 75 | -1 | $738 | $610,041 | 4 | Warner Bros. | false | false |
| 12 | 8 | G-Force | $43,450 | -39.2% | 173 | -26 | $251 | $3,924,787 | 7 | Walt Disney Pictures | false | false |
| 13 | 10 | Two Lovers | $40,084 | +0.2% | 44 | +7 | $911 | $512,079 | 5 | PlayArte Pictures | false | false |
| 14 | - | Diary of a Nymphomaniac | $23,143 | - | 34 | - | $680 | $23,143 | 1 | PlayArte Pictures | true | false |
| 15 | 15 | Brüno | $14,627 | -13.7% | 34 | -10 | $430 | $1,149,454 | 7 | Sony Pictures Releasing | false | false |
| 16 | 13 | Antichrist | $13,773 | -35% | 12 | -1 | $1,147 | $198,098 | 5 | N/A | false | false |
| 17 | 14 | The Proposal | $12,821 | -25.7% | 36 | -15 | $356 | $6,829,301 | 12 | Walt Disney Pictures | false | false |
| 18 | 26 | The Story of Me | $11,871 | +116.7% | 37 | +15 | $320 | $543,658 | 8 | Warner Bros. | false | false |
| 19 | - | Shorts | $11,107 | - | 43 | - | $258 | $225,830 | 5 | Warner Bros. | false | false |
| 20 | 12 | Bandslam | $10,685 | -61.6% | 65 | -17 | $164 | $120,823 | 3 | Paris Filmes | false | false |
| 21 | 11 | Che: Part Two | $10,250 | -65.6% | 31 | -3 | $330 | $54,530 | 2 | Europa Filmes | false | false |
| 22 | 19 | G.I. Joe: The Rise of Cobra | $9,381 | -20% | 35 | -7 | $268 | $3,278,816 | 8 | Paramount Pictures International | false | false |
| 23 | 18 | The Wave | $8,408 | -31.5% | 10 | -5 | $840 | $142,635 | 6 | N/A | false | false |
| 24 | 16 | Doomsday | $7,280 | -55.7% | 31 | -2 | $234 | $184,371 | 6 | Europa Filmes | false | false |
| 25 | 17 | Time of Peace | $6,946 | -48.2% | 33 | -6 | $210 | $390,038 | 7 | N/A | false | false |
| 26 | 20 | Harry Potter and the Half-Blood Prince | $6,464 | -42.2% | 10 | -6 | $646 | $18,889,818 | 11 | Warner Bros. | false | false |
| 27 | - | Drag Me to Hell | $6,281 | - | 47 | - | $133 | $1,657,134 | 7 | Universal Pictures International (UPI) | false | false |
| 28 | 25 | The Butterfly Effect 3: Revelations | $5,289 | -4.4% | 25 | +2 | $211 | $606,118 | 9 | N/A | false | false |
| 29 | 21 | Adrift | $4,999 | -54.6% | 23 | -3 | $217 | $429,509 | 9 | Universal Pictures International (UPI) | false | false |
| 30 | 23 | Last Chance Harvey | $4,798 | -46% | 23 | -4 | $208 | $791,723 | 15 | N/A | false | false |
| 31 | 22 | Ice Age: Dawn of the Dinosaurs | $4,547 | -51.5% | 42 | -9 | $108 | $42,316,880 | 13 | 20th Century Fox International | false | false |
| 32 | 30 | The Invisible Woman | $3,448 | +1.1% | 19 | -3 | $181 | $10,669,109 | 17 | Warner Bros. | false | false |
| 33 | 27 | The Accidental Husband | $2,882 | -43.4% | 24 | -11 | $120 | $1,056,833 | 8 | PlayArte Pictures | false | false |
| 34 | 32 | The International | $378 | -74.4% | 5 | -5 | $75 | $624,823 | 15 | Sony Pictures Releasing | false | false |
| 35 | 36 | Waltz with Bashir | $53 | -18.5% | 1 | - | $53 | $111,235 | 26 | Sony Pictures Releasing | false | false |
| 36 | 35 | Hannah Montana: The Movie | $31 | -63.5% | 1 | -1 | $31 | $2,610,631 | 16 | Walt Disney Pictures | false | false |
| 37 | 34 | Frozen River | $24 | -73% | 1 | -1 | $24 | $49,510 | 32 | Sony Pictures Releasing | false | false |
